1st Edition

Biosensors Based on Nanomaterials and Nanodevices

Edited By

Jun Li


Nianqiang Wu

ISBN 9781138073258
Published March 29, 2017 by CRC Press
517 Pages 217 B/W Illustrations

USD $89.95

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Book Description

Biosensors Based on Nanomaterials and Nanodevices links interdisciplinary research from leading experts to provide graduate students, academics, researchers, and industry professionals alike with a comprehensive source for key advancements and future trends in nanostructured biosensor development. It describes the concepts, principles, materials, device fabrications, functions, system integrations, and applications of various types of biosensors based on signal transduction mechanisms, including fluorescence, photonic crystal, surface-enhanced Raman scattering, electrochemistry, electro-luminescence, field-effect transistor, and magnetic effect. The book:

  • Explains how to utilize the unique properties of nanomaterials to construct nanostructured biosensors to achieve enhanced performance
  • Features examples of biosensors based on both typical and emerging nanomaterials, such as gold nanoparticles, quantum dots, graphene, graphene oxides, magnetic nanoparticles, carbon nanotubes, inorganic nanowires/nanorods, plasmonic nanostructures, and photonic crystals
  • Demonstrates the broad applications of nanostructured biosensors in environmental monitoring, food safety, industrial quality assurance, and in vitro and in vivo health diagnosis
  • Inspires new ideas for tackling multiscale and multidisciplinary issues in developing high-performance biosensors for complex practical biomedical problems

Focusing on the connection between nanomaterials research and biosensor development, Biosensors Based on Nanomaterials and Nanodevices illustrates the exciting possibilities and critical challenges of biosensors based on nanomaterials and nanodevices for future health monitoring, disease diagnosis, therapeutic treatments, and beyond.

Table of Contents



Opportunities and Challenges of Biosensors Based on Nanomaterials and Nanodevices
Jun Li and Nianqiang (Nick) Wu

Optical Biosensors

Synthesis and Characterization of Quantum Dots
Haiguang Zhao and Dongling Ma

Quantum Dots for Bioimaging
Zoraida P. Aguilar

Fluorescent Sensors Based on Energy Transfer and Charge Transfer
Ming Li and Nianqiang (Nick) Wu

Graphene-Based Optical Biosensors and Imaging
Zhiwen Tang, Shijiang He, Hao Pei, Dan Du, Chunhai Fan, and Yuehe Lin

Biosensing Based on Surface-Enhanced Raman Spectroscopy
Gang Logan Liu, Wenwei Zheng, Pingping Zhang, and Fanqing (Frank) Chen

In Vivo Biodetection Using Surface-Enhanced Raman Spectroscopy
Seunghyun Lee, Ulhas S. Kadam, Ana Paula Craig, and Joseph Irudayaraj

Photonic Crystal Biosensors
Bashar Hamza, Maurya Srungarapu, Anand Kadiyala, Jeremy Dawson, and Lawrence Hornak

Nanomaterial-Based Electrochemiluminescence Biosensors
Rongfu Huang and Liang-Hong Guo

Electrical Biosensors
Nanocrystalline Diamond Biosensors
Prabhu U. Arumugam, Shabnam Siddiqui, Hongjun Zeng, and John A. Carlisle

Carbon Nanotube-Based Electrochemical Biosensors
Feng Du, Lin Zhu, and Liming Dai

Vertically Aligned Carbon Nanofibers for Biointerfacing
Ryan Pearce, Timothy E. McKnight, and Anatoli Melechko

Graphene-Based Electrochemical Biosensors
Chun Xian Guo, Shu Rui Ng, and Chang Ming Li

Bioelectronics on Graphene
Vikas Berry

Nanowire Field-Effect Transistor Biosensors
Fumiaki Ishikawa, Xiaoli Wang, Noppadol Aroonyadet, and Chongwu Zhou

Magnetic Nanoparticles for Biosensing and Cancer Treatment
Biosensing and Cancer Treatment with Magnetic Nanoparticles
Stefan Bossmann, Viktor Chikan, and Raj Kumar Dani

Biosensors Based on Thermal Properties

Solid-Liquid Phase Change Nanoparticles as Thermally Addressable Biosensors
Chaoming Wang, Yan Hong, Liyuan Ma, and Ming Su

Microfluidic and Lab-on-Chip Technologies for Biosensors
Yuxin Liu and Xiang Li


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Jun Li holds a PhD in chemistry from Princeton University, New Jersey, USA. A recipient of NASA Tech Briefs’ Nano50 Innovator Award, he has engaged in research at Cornell University, Ithaca, New York, USA; Molecular Imaging Inc., Ann Arbor, Michigan, USA; Institute of Materials Research and Engineering, Singapore; NASA Ames Research Center, Mountain View, California, USA; and Kansas State University, Manhattan, USA—where he currently serves as professor. A co-inventor of 15 patents and an associate editor for IEEE Transactions on Nanotechnology, he has published 120 peer-reviewed papers/book chapters and his work has been highlighted in over 40 news reports.

Nianqiang (Nick) Wu currently serves as associate professor for West Virginia University, Morgantown, USA; secretary of the Electrochemical Society’s Sensor Division; and advisory board member for Interface, the home journal of the Electrochemical Society. He holds a PhD in materials science and engineering from Zhejiang University, Hangzhou, People’s Republic of China. Previously he was a postdoctoral fellow at University of Pittsburgh, Pennsylvania, USA and directed Keck Surface Science Center at Northwestern University, Evanston, Illinois, USA. He has organized several symposia on biosensors and solar fuels, holds four patents/disclosures, and has published three book chapters and more than 110 journal papers.


"Biosensors Based on Nanomaterials and Nanodevices explains the essential technologies in nanotube-combined biosensors. From the optical biosensors using nanoscale materials, the book covers very recent technologies, including electrical, magnetic, and thermal biosensors. The concise theories of each sensor platform provide a good introduction for a general audience with a background at the university level. Readers can find information about optical biosensors using nanomaterials and nanodevices in the first section of the book. The optical methods have been studied extensively because of their high potential for biosensing applications. These methods have the advantages of reliability, sensitivity, selectivity, and applicability for in vivo detection, and an extensive discussion is included in the text. In the beginning of the section, the fundamental theories and techniques provide a guideline for beginning scholars, and, using the plasmonic nanomaterials, the surface-enhanced Raman spectroscopy techniques are intensively introduced. Furthermore, photonic crystals and electroluminescence sensor platforms are explained with a new concept of the future biosensors. In the second section, electrical biosensors are reviewed with novel nanomaterials such as diamond, carbon nanotubes, graphene, and inorganic semiconductor nanowires. The electrical techniques are also widely developed because they are suitable for handheld electronic devices. Using nanomaterials allows for the enhancement of the sensor characteristics, and novel applications, such as neuron interfacing and cellular detection, are enabled. Recent advances on these techniques with well-established theories and examples are found in this book. Nanomaterials are being developed not only for the detection but for in vivo treatment. Magnetic nanoparticles are described in the third section, including synthesis and applications. Readers can find recent information about bioseparation, drug delivery, and hyperthermia treatment using these particles. In the final section, other new concepts of nanoscale platforms are introduced, such as multiplexed detection using thermally addressable biosensors and microfluidics for biosensor applications. The book provides excellent information on well-established and emerging techniques to readers who are interested in next-generation biosensor platforms. It has fulfilled the need to provide information on nanomaterial-based sensors with substantial theory. As a nanoscale semiconductor biosensor engineer, I recommend this book to colleagues and students."
--Taiuk Rim, IEEE Nanotechnology Magazine, September 2014