1st Edition

Biotic Type Antioxidants: the prospective search area for novel chemical drugs

By Gennady Zaikov, Parfenov Copyright 2000

    The discovery of molecular and cellular mechanisms of pathology, together with the present data on drug treatment result in enhanced drug design and testing. The known mechanisms of biological activity as displayed by ascorbic acid and other natural reductones are the reason that they are considered to be physiologically compatible antioxidants, many of which are trace elements in food. The pharmacological potential of natural antioxidants may be enhanced by chemical modification. Biotic antioxidants possess an important potential to be a reliable basis of the development of new multipurpose drugs, within the framework of existing technological structures. This book shows approaches for possible use of these natural antioxidants. In particular, such an approach is described for the case of the design of superoxide dismutase models with anti-tumour activity.

    Preface CHAPTER 1. REDUCTONES AS A VARIETY OF ANTIOXIDANTS OF THE BIOTIC TYPE 1.1. Introduction 1.2. Natural reductones 1.2.1. Asorbic acid (AA) 1.2.2. Coumarin reductones of the aliphatic type 1.2.3. Polyphenoles of vegetable and animal origin 1.2.4. Other heterocyclic compounds 1.3. Conclusion CHAPTER 2. ANTITUMOUR POTENTIAL OF SUPEROXIDE DISMUTASE MODEL 2.1. Introduction 2.1.1. The notion of superoxide dismutase models 2.1.2. Superoxide dismutase and cancer 2.1.3. SOD models and cancer 2.1.4. Copper metabolism and oncological diseases 2.1.5. Antitumour effect of inorganic copper salts 2.2. The search for antitumour agents among complex copper compounds 2.2.1. Salicylate SOD models 2.2.2. Other carboxylate SOD models 2.2.3. Amino acid and peptide SOD models 2.2.4. Other types of SOD models 2.2.5. Stable SOD models 2.2.6. The search for effective chelators 2.2.7. Concept of iron chelators 2.2.8. Principles of SOD model design 2.3. Molecular mechanisms of the SPD model antitumour effects 2.3.1. SOD models as anticarcinogenes 2.3.2. SOD models as antitumour agents 2.3.3. Prooxidant activity of SOD models 2.3.4. Mechanisms of physiological compatibility of SOD models 2.3.5. Is a universal antioxidant possible? CHAPTER 3. HOW TO TRANSFORM AVAILABLE KNOWLEDGE INTO SPECIFIC ELABORATIONS 3.1. Raw material sources and technological scheme 3.2. Estimation of the possibilities of the technological scheme suggested by the assortment of products 3.3. Conclusion Subject index List of abbreviations


    Parfenov, E A.