Brain Aging: Models, Methods, and Mechanisms, 1st Edition (Hardback) book cover

Brain Aging

Models, Methods, and Mechanisms, 1st Edition

Edited by David R. Riddle

CRC Press

408 pages | 13 Color Illus. | 48 B/W Illus.

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Hardback: 9780849338182
pub: 2007-04-19
eBook (VitalSource) : 9780429114571
pub: 2007-04-19
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Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur, new possibilities emerge for limiting the effects of aging on neural function. A single source reference is necessary to keep abreast of the recent advances and future directions of gerontology research.

Brain Aging: Models, Methods, and Mechanisms offers a selective overview of the research in this rapidly expanding field. A valuable resource for new and established investigators of the aging brain, this volume reviews critical studies of brain aging in new animal models, as well as advances in brain imaging techniques that permit investigations in aging humans with increasingly higher resolution. Detailed discussions link the information from human and animal studies to illustrate a comprehensive picture of the mechanism of aging.

Emphasizing normal brain aging rather than pathological degeneration, the text provides an understanding of fundamental age-related changes in the nervous system and hypothesis-driven research into their basis. The book includes critical analyses of the distinct methodological challenges inherent in investigating the aging nervous system. Contributions from distinguished leaders and pioneers in their respective fields address data and mechanisms, as well as models and methods that are key to the study of aging. Each chapter is extensively referenced and highlights experimental concerns that are magnified or unique to the aging brain.

Outlining relevant methods and techniques, this book provides scientists, researchers, and clinicians with a broad understanding of the important progress and implications for the future of this significant field.


"The value of Brain Aging: Models, Methods, and Mechanisms for the psychologist will be in gaining a greater awareness of the depth and breadth of recent advances in knowledge regarding the again brain. For those who work with older persons, many insights will undoubtedly be new."

– Richard H. Cox, in PsychCRITIQUES, November 2007, Vol. 52, No. 46

Table of Contents

Assessing Cognitive Aging

Changes in Cognitive Function in Human Aging, E. L. Glisky

Successful vs. Unsuccessful Aging in Rhesus Monkeys, M.B. Moss, T. L. Moore, S.P. Schettler, R.  Killiany, and D. Rosene

Neuropsychology of Cognitive Aging in Rodents, J. S. Rodefer and M. G. Baxter

Quantifying Aging-Related Changes in the Brain

Design-Based Stereology in Brain Aging Research, C. Schmitz and P.R. Hof

The Effects of Normal Aging on Nerve Fibers and Neuroglia in the Central Nervous System, A. Peters

Neurogenesis in the Adult and Aging Brain, D.R. Riddle and R.J. Lichtenwalner

Expression Profile Analysis of Brain Aging, S.D. Ginsberg, Ph.D.

Assessing Functional Changes in the Aging Nervous System

Subtle Alterations in Glutamatergic Synapses Underlie the Aging-Related Declines in Hippocampal Functions, L. Shi, M. Adams, and J. Brunso-Bechtold

Assessment of Second Messenger Function in the Hippocampus of Aged Rats with Cognitive Impairment, M.M. Nicolle, H.Y.  Zhang, and J. L. Bizon

Neurophysiology of Old Neurons and Synapses, A. Kumar and T. C. Foster

Imaging Cognition in the Aging Human Brain, T. Hedden

Mechanisms Contributing to Brain Aging

Regulation of Cerebrovascular Aging, W.E. Sonntag, D.M. Eckman, J.Ingraham, and D.R. Riddle

Stress and Glucocorticoid Contributions to Normal and Pathological Aging, K.A. Goosens and R.M. Sapolsky

Altered Calcium Homeostasis in Old Neurons, E.C. Toescu

Oxidative Stress and the Aging Brain: from Theory to Prevention, C.Gemma, Ph.D., J. Vila, A. Bachstetter, and P. C. Bickford, Ph.D.


About the Series

Frontiers in Neuroscience

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Anatomy
MEDICAL / Geriatrics
SCIENCE / Life Sciences / Neuroscience