1st Edition
Brain Drug Delivery for the Treatment of Neurological Disorders
List of Contributors
About the Editor
Abbreviation List
Chapter 1: Neurological Disorders and Their Impact
Jidhin Raj and Rhys Davies
Chapter 2: Physiological Barriers of Targeting the Diseased Brain
Hakan Sahin
Chapter 3: Poly (ADP-Ribose) Polymerase (PARP) as a Novel Therapeutic Target for Developing Treatments Against Neurological and Neurodegenerative Conditions
Saheed O. Benson and Amos A. Fatokun
Chapter 4: Targeting Microglia for the Treatment of the Diseased Brain
Touraj Ehtezazi, Luca Peruzzotti-Jametti, Stefano Pluchino, and Darren Sexton
Chapter 5: Novel Nanoparticles as Drug Delivery Systems to the Brain
Touraj Ehtezazi and Changiz Taghibiglou
Chapter 6: Exosomes for Drug Delivery to the Brain
Mosavar Farahani
Chapter 7: Targeting the Brain with Monoclonal Antibodies
Shreyansh Chauhan, Jai Naik, and Mayur Patel
Chapter 8: In Vitro Evaluations of Drug Delivery to the Brain
Touraj Ehtezazi
Chapter 9: In Vivo Evaluations of Drug Delivery to the Brain
Touraj Ehtezazi
Chapter 10: Introduction to Hematological and Immunological Safety in Brain Drug Delivery
Riya Patel, Bindu Kumari Yadav, Shreeraj Shah, and Bhupendra Prajapati
Chapter 11: Cytotoxic Evaluations of the Drug Delivery Systems to the Brain
Humaira Liaqat, Huma Hameed, Mahtab Ahmad Khan, Ana Cláudia Paiva-Santos, Muhammad Zaman, and Anam Hameed
Chapter 12: Personalised Therapies for Rare Neurological Disorders
Bhupendra Prajapati, Touraj Ehtezazi, Yashwant Pathak, Riya Patel, and Disha Joshi
Chapter 13: Industrial Aspects to Be Considered for Drug Delivery for Brain
Selin Akpinar Adscheid, Akif E. Türeli, and Nazende Günday-Türeli
Chapter 14: Regulatory Aspects to Be Considered in the Development of Drug Delivery Systems to the Brain
Touraj Ehtezazi
Index
Biography
Dr. Touraj Ehtezazi is a Reader in Pharmaceutics at Liverpool John Moores University. A pharmacist by training, he graduated from the University of Tabriz, Iran, and obtained his PhD from the University of Nottingham in 1997. He conducted postdoctoral studies at the University of Nottingham in 1998 and held a lectureship at the University of Leicester from 2000.
Since joining Liverpool John Moores University in 2002, Dr. Ehtezazi has established himself as a leading researcher in drug delivery to the brain. He has published extensively in peer-reviewed journals, with particular focus on neuroinflammation, traumatic brain injury, Alzheimer's disease, and multiple sclerosis, including editing a special issue dedicated to brain drug delivery. Dr. Ehtezazi has contributed to the planning of major Horizon-2020 projects addressing the treatment of neurological disorders. His work combines expertise in pharmaceutical formulation, mathematical modelling, and targeted drug delivery systems to advance therapeutic strategies for challenging neurological conditions.
