Brain Slices in Basic and Clinical Research  book cover
1st Edition

Brain Slices in Basic and Clinical Research

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ISBN 9780849347603
Published April 13, 1995 by CRC Press
352 Pages

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Book Description

Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following:

  • Mechanisms of synaptic plasticity as the basis of memory processes
  • Chaos and synaptic variability
  • Brain calcium currents
  • Glutamate receptors
  • Pathophysiology of excitotoxins
  • Cerebral hypoxia-ischemia
  • Neuronal injury
  • Free radicals
  • Optical methods of measuring brain metabolism
  • Voltammetry in brain slices
  • Calcium imaging
  • Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices
  • Intracellular double labeling of various neuronal populations
  • Use of brain slices in teaching neurophysiological methods
    Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.
  • Table of Contents

    Advances in Understanding the Mechanisms Underlying Synaptic Plasticity, T. Teyler, I. Cavus, C. Coussens, P. DiScenna, L. Grover, Y. Lee, and Z. Little
    Chaotic Components of Synaptic Variability in Hippocampal Pathways, P.G. Aitken, S.J. Schiff, and T. Sauer
    Intrinsic Optical Properties of Brain Slices: Useful Indices of Electrophysiology and Metabolism, T.J. Sick and J.C. LaManna
    Voltammetry in Brain Slices, J.A. Stamford
    Imaging of Intracellular Calcium in Hippocampal Slices: Methods, Limitations, and Achievements, M. Segal and J.M. Auerbach
    Patch-Clamp Recording in Brain Slices, F.A. Edwards
    Intracellular Application of Macromolecules through Patch Pipettes in Brain Slices, M. Alreja and G.K. Aghajanian
    Intracellular Double Labeling of Substantia Nigra and Pedunculopontine Neurons in In Vitro Slice Preparation, S.T. Kitai and Y. Kuga
    The Importance of Temperature Control When Investigating High-Threshold Calcium Currents in Mammalian Neurones, R.H. McAllister-Williams and J.S. Kelly
    A Neurochemical Approach to Elucidate Metabotropic vs. Ionotropic Glutamate Receptor Activities in Rat Hippocampal Slices, D.D. Schoepp and M.A. Desai
    Radiotracer Labeling of Brain Slices, G.C. Newman, F.E. Hospod, C.S. Patlak, and H. Qi
    The Pharmacology of Excitotoxins and Energy Deprivation in Hippocampal Slices, A. Schurr and B.M. Rigor
    Delayed Neuronal Injury in the Hippocampal Slice, R.-A. Wallis and K.L. Panizzon
    Gene Expression as an Index of Pathophysiology Associated with Slice Preparation, T.S. Nowak, Jr., Q. Zhou, P.J. Voulalas, and J.M. Sarvey
    Studies on Anoxic Depolarization, M. Balestrino
    The Use of Brain Slices in the Study of Free Radical Actions, T.C. Pellmar
    Using the In Vitro Hippocampal Slice as a Model to Teach Methods in Neurophysiology, S. Veregge

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    Schurr\, Avital; Rigor\, Benjamin M.


    "...a valuable resource for graduate students, postdoctoral fellows, and even principal investigators interested in learning how to apply brain slice technology to the study of neurological function."
    -Trends in Endocrinology and Metabolism