424 Pages 107 Color & 135 B/W Illustrations
    by CRC Press

    424 Pages 107 Color & 135 B/W Illustrations
    by CRC Press

    This second edition comes at a time of a paradigm shift in understanding of the molecular pathology and neuroscience of brain and spinal tumors of childhood and their mechanisms of growth within the developing brain. Excellent collaborative translational networks of researchers are starting to drive change in clinical practise through the need to test many ideas in trials and scientific initiatives. This text reflects the growing concern to understand the impact of the tumour and its treatment upon the full functioning of the child’s developing brain and to integrate the judgments of the risks of acquiring brain damage with the risk of death and the consequences for the quality of life for those who survive. Information on the principles of treatment has been thoroughly updated. A chapter also records the extraordinary work done by advocates. All medical and allied professionals involved in any aspect of the clinical care of these patients will find this book an invaluable resource.

    List of Contributors

    1. Introduction

    David A. Walker, Giorgio Perilongo, Roger E. Taylor, and Ian F. Pollack

    2. Epidemiology of Childhood Brain Tumors

    Richard J. McNally and Paul Graham Fisher

    3. Clinical Presentation and Associated Syndromes of Brain Tumor

    David Walker, JoFen Liu, and Dhurgsharna Shanmugavadivel

    4. Pediatric Central Nervous System Tumors as Phenotypic Manifestation of Cancer Predisposition Syndromes

    Giorgio Perilongo, Irene Toldo, and Stefano Sartori

    5. Anatomical and Biological Imaging of Pediatric Brain Tumor

    Rob A. Dineen, Shivaram Avula, Andrew C. Peet, Giovanni Morana, and Monika Warmuth- Metz

    6. Neurosurgical Techniques and Strategies

    Jonathan E. Martin, Ian F. Pollack, and Robert F. Keating

    7. Radiotherapy for Pediatric Central Nervous System Tumors – Techniques and Strategies

    Nicola Thorp

    8. Physical and Cognitive Rehabilitation for Children with Brain and Spinal Tumors

    Alexandra M. Gaynor, Helen Hartley, and Stephen A. Sands

    9. Drug Delivery

    Gudrun Fleischhack, Martin Garnett, and Kévin Beccaria

    10. Low- grade Glioma Presenting in the Optic Pathways and Hypothalamus (NF1. and Sporadic)

    Peter M.K. de Blank, Ian Simmons, Astrid Sehested, and Michael J. Fisher

    11. Low- grade Glioma: Principles of Diagnosis and Drug Treatment

    Pablo Hernáiz Driever, Olaf Witt, Astrid Gnekow, Daniela Kandels, and Mark Kieran

    12. High- grade Glioma

    Donald C. Macarthur, Christof M. Kramm, and Matthias A. Karajannis

    13. Diff use Intrinsic Pontine Glioma

    Katherine E. Warren, Carolyn R. Freeman, and Dannis G. van Vuurden

    14. Embryonal Tumors

    Simon Bailey and Jeff Michalski

    15. Ependymoma in Childhood and Adolescence

    Richard Grundy and Eric Bouffet

    16. Germ Cell Tumors of the Central Nervous System

    Matthew J. Murray, Ute Bartels, and James C. Nicholson

    17. Atypical Teratoid / Rhabdoid Tumors – AT/ RT

    Michael C. Frühwald, Jaclyn A. Biegel, and Susan N. Chi

    18. Craniopharyngioma

    Hermann L. Müller, Claire Alapetite, and Jeffrey Wisoff

    19. Choroid Plexus Tumors and Meningiomas

    Kenneth K. Wong, Elwira Szychot, Jennifer A. Cotter, and Mark Krieger

    20. Pediatric Spinal Tumors

    Rajiv R. Iyer, Nir Shimony, Mohammad Hassan A. Noureldine, Eric Bouffet, and George I. Jallo

    21. Late Effects of Treatment for Childhood Brain and Spinal Tumors

    Ralph Salloum, Katherine Baum, Melissa Gerstle, Helen Spoudeas, and Susan R. Rose

    22. The Power of Patient Advocacy in Pediatric Neuro-oncology

    Kathy Oliver, Susan Awrey, Mark Brougham, Gloria Garcia Castellvi, Anita Granero, Rakesh Jalali, Sacha Langton-Gilks, Yuko Moue, Kathy Riley, Bonita Suckling, Hisato Tagawa, and Raees Tonse



    David A. Walker is Professor Paediatric Oncology, School of Medicine, University of Nottingham, Nottingham, UK
    Giorgio Perilongo is Director, Department of Woman’s and Child’s Health, Division of Pediatrics, University of Padua, Padua, Italy
    Roger E. Taylor is Professor of Clinical Oncology, College of Medicine, Swansea University; Honorary Consultant Clinical Oncologist, South West Wales Cancer Centre, Singleton Hospital, Swansea, UK
    Ian F. Pollack is Chief, Pediatric Neurosurgery, Children's Hospital of Pittsburgh, Leland Albright Distinguished Professor of Neurological Surgery, Vice Chairman for Academic Affairs, Department of Neurological Surgery, Co-Director, UPCI Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    "a clearly written text that provides a relevant overview … succinct and streamlined, making it a practical yet still reasonably comprehensive resource"

    - Esther Dupepe, MSPH, MD (Ochsner Health System)