Considering the impact of translational breakthroughs on the early detection, diagnosis, prevention, and treatment of breast cancer, this all-encompassing guide collects cutting-edge research on the most promising strategies and agents likely to impact the management and long-term outcomes of women with breast cancer. This book will provide current information on rapidly evolving translational therapies, as well as improved strategies for the selection of patients for these treatments.
METHODS AND FRAMEWORK. Clinical Trials of Novel and Targeted Therapies: Endpoints, Trial Design, and Analysis. Prognostic models: A Methodological Framework and Review of Models for Breast Cancer. Challenges of Microarray Data and the Evaluation of Gene Expression Profile Signatures. Preoperative Therapy as a Model for Translational Research in Breast Cancer. Pharmacology And Pharmacogenetics of Chemotherapeutic Agents. Aging, Cancer, and Translational Research. MOLECULAR AND CELLULAR MARKERS OF PROGNOSIS. The Prognostic Implications of Circulating Tumor Cells in Patients with Breast Cancer. The Prognostic Impact of Bone Marrow Micrometastases in Women with Breast Cancer. The Prognostic Importance of Isolated Tumor Cell Clusters and Micrometastases in Sentinel Lymph Nodes. Molecular Subtypes in Breast Cancer Evaluation and Management: Divide and Conquer. Development and Validation of Gene Expression Profile Signatures in Early-Stage Breast Cancer. Gene Expression Profile Assays as Predictors of Distant Recurrence-Free Survival in Early Stage Breast Cancer. Economic Analysis of Gene Expression Profile Data to Guide Adjuvant Treatment in Women with Early-Stage Breast Cancer. NOVEL THERAPIES AND TREATMENT. Aromatase Inhibitors for Breast Cancer Treatment and Prevention. Fulvestrant: A Novel Hormonal Agent. HER2-Positive Breast Cancer: Current Treatment Strategies. Is there a Role for ErbB Dual Kinase Inhibition?. Anti-Epidermal Growth Factor Receptor Strategies for Advanced Breast Cancer. Farnesyl Transferase Inhibitors. nab-Paclitaxel: Reducing Toxicity Using Albumin-Bound Particles as the Carrier for Paclitaxel. The Epothilones. Antiangiogenic Agents in Breast Cancer. Epigenetic Regulation as a New Target for Breast Cancer Therapy. Tumor Vaccines for Breast Cancer