This two-volume handbook provides important information concerning the development, implementation, evaluation, uses, advantages, and limitations of a wide variety of animal model of pulmonary disease. While the work focuses on stepwise procedures for inducing and quantifying disease, additional emphasis is placed on each model's relationship to human counterparts and on comparisons with similar models of injury. Thus, even the novice researcher will be able to more sharply define a particular research question, find suitable animal models for study, gain access to specialized techniques, and evaluate results within the context of an up-to-date body of information about related forms of lung diseases.
1. Elastase-Induced Emphysema 2. Cadmium Chloride-Induced Emphysema in Lathyrogenic Hamsters 3. Copper Deficiency-Induced Emphysema 4. Toluene Diisocyanate-Induced Airway Injury 5. Progressive Lung Injury and Pulmonary Hypertension from Monocrotaline 6. Lung Injury Induced by Intravenous Administration of Heterologous Polyclonal Antibodies to Angiotensin Converting Enzyme 7. Granulomatous Lung Disease Induced by Complete Freund's Adjuvant or BCG 8. Compensatory Hyperplastic Growth of the Lung 9. Fetal Lung Hypoplasia 10. Lung Injury Induced by Nutritional Restriction 11. Lung Cancer Models in Animals 12. Sheep Lung Lymph Fistula Preparation Applied to Measurements of Complement-Mediated Pulmonary Microvascular Injury 13. The Isolated, Perfused Lung Preparationex