1st Edition
CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases
The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.
1. The CRISPR/Cas9 Genome-editing System: Principles and Applications
Cecilia Pop-Bica, Andreea Nutu, Roxana Cojocneanu, Sergiu Chira and Ioana Berindan-Neagoe
2. Recent Applications of CRISPR-Cas9 in Genome Mapping and Sequencing
Dharma Varapula, Lahari Uppuluri and Ming Xiao
3. Gene Editing and Genetic Disorders: Ethical and Legal Concerns
Vicente Bellver and Federico de Montalvo
4. Political, Regulatory and Ethical Considerations of the CRISPR/Cas Genome Editing Technology
Eduardo Rodriguez Yunta and Luis María Vaschetto
5. CRISPR/Cas and Gene Therapy: An Overview
Luis María Vaschetto
6. CRISPR and Cancer: From Bench to Clinic
Muhammad Usama Tariq and Amina Chaudhry
7. The Advances of the CRISPR/Cas9 Technology for Correcting Genetic Disorders: Using Sarcoma as a Model System
Pichaya Thanindratarn, Dylan C. Dean, Francis J. Hornicek and Zhenfeng Duan
8. CRISPR/Cas9 Technology as a Strategy Against Viral Infections
Huafeng Lin, Haizhen Wang, Jun He, Xiangwen Peng, Aimin Deng, Lei Shi, Lei Ye and Hanyue Gong
9. CRISPR/Cas9-based Genome and Epigenome Editing in Neuroscience Research
Nereo Kalebic and Wieland B. Huttner
10. Non-viral Alternatives to Delivery of CRISPR-Cas Gene Editing Components
Kate Senger and Benjamin Haley
11. CRISPR Medicine: Advance, Progress and Challenges
Guillermo Ureña-Bailén, Justin S. Antony, Yujuan Hou, Janani Raju, Andres Lamsfus-Calle, Alberto Daniel-Moreno, Rupert Handgretinger and Markus Mezger
Biography
Luis María Vaschetto received his Doctorate in Biological Sciences from Universidad Nacional de Córdoba (Argentina). He was a postdoctoral researcher at the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and a research associate at South Dakota State University (SDSU). His research focuses on understanding the epigenetic mechanisms involved in plant and animal development, as well as their effects on human health and diseases.
'Overall, this is an excellent book and a valuable contribution to the burgeoning field of human genome editing. Each chapter is well sourced and has an extensive list of references. Indeed, more than 25 percent of the 259 numbered
pages in the book are devoted to references. This book offers an excellent starting point for exploration of genome editing in humans and is highly recommended.'- Mark F. Sanders, PhD, UC Davis College of Biological Sciences
