This title primarily focuses on the functional mechanisms and roles of Ca2+ channels in the central nervous system, and the effects of Ca antagonists on cytosolic CA2+ by blocking voltage sensitive channels. These findings are an important contribution to understanding the mechanisms of brain dysfunctions, including Alzheimer's disease, cerebral ischemia and affective disorders, as well as the effects of cytosolic CA2+ modulators on neuronal cell death. In addition the results of clinical trials are reported using typical and atypical Ca antagonists in the treatment of neuropsychiatric diseases.
An essential reference to some of the most current and vital research into Ca antagonists as therapeutic agents, this monograph is invaluable for all clinical and pre-clinical researchers active in the multidisciplinary fields of neuroscience, including: psychopharmacology, molecular biology, behavioral pharmacology, neuropharmacology, and electrophysiology and immunology. Investigators of Ca2+ dynamics and brain dysfunction especially will find this book useful in the development of novel drugs to treat neuropsychiatric diseases.
Part 1. Central Ca Ion Channels and their Physiological Role in the Central Nervous System (CNS) Part 2. Neuronal Regulation and Protection by Ca Antagonists Part 3. Neuronal Regulation and Protection by Novel Ca Ion Modulators Part 4. Psychiatric Disease and Ca Antagonists Part 5. Psychiatric Diseases and Novel Ca Ion Modulators Part 6. New Concept for Antipsychosis of Ca Ion Modulator