Calcium Signalling in Cancer: 1st Edition (Hardback) book cover

Calcium Signalling in Cancer

1st Edition

By G. V. Sherbet

CRC Press

384 pages | 28 B/W Illus.

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pub: 2000-11-29
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Description

Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feature of cell adhesion and motility; the integrity of the calcium binding proteins themselves is a basic requirement of normal biological function. In fact, the deregulation of calcium signaling is now regarded as the primary event in the pathogenesis, growth, invasion, and secondary spread of cancer.

Calcium Signalling in Cancer is a concise up-to-date treatise on the transduction signals induced by calcium that considers how alterations in this calcium-dependent signal transduction pathway are related to a number of human diseases, especially neoplastic transformation. This authoritative text examines a broad range of topics-from mechanisms and significance of calcium homeostasis for normal cell function to calcium signalling pathways and the transduction of the calcium signal, especially in proliferation, cell motility, cancer invasion,, and metastasis.

Clearly organized, it covers all aspects of the subject including specific sections on the regulation of the genes whose products are required for signal transduction by calcium, such as Alzheimer's disease, Darier's disease, Duchenne and limb girdle dystrophies, psoriasis and some forms of ichthyosis, and cancer associated retinopathy. With an extensive bibliography and over 2,500 references, Calcium Signalling in Cancer is an invaluable reference source.

Table of Contents

Preface

Abbreviations

Introduction

The Calcium Signalling Pathway

Homeostasis of Cell Calcium

Phospholipid Signalling

PTEN Phosphatase in the Regulation of Lipid

Signalling

The Protein Kinase C Pathway

Protein Kinase C and Its Isoforms in Signal

Transduction

Inositol Phosphates in Signal Transduction

Deregulation of Inositol 1,4,5-Trisphosphate Pathway

and Its Consequences

Ryanodine and Related Receptors in Calcium

Mobilisation

Cyclic AMP in Calcium Signalling

Architectural Aspects of the Signal Transduction

Machinery

Calcium Binding Proteins and Their Natural Classification

Non-EF-Hand Calcium Binding Proteins

Annexins

The Gelsolin Family Calcium Binding Proteins

Calreticulin and Its Functional Diversity

Calsequestrin and Intracellular Calcium Storage

Osteocalcin in Bone Metabolism and Osteotropism

of Cancer

The EF-Hand Calcium Binding Proteins

Molecular Organisation of Calcium Binding EF Hand

Proteins

Calcium Binding and the Molecular Configuration of

Calcium Binding Proteins

The Structure and Organisation of S100 Family

Genes

Alternatively Spliced Variants of S100A4

Functional Significance of Alternatively Spliced

Isoforms

Regulation of Expression of S100 Family Genes

The Calmodulin Family of Calcium Binding Proteins

Calmodulin and its Physiological Function

Recoverin Subfamily of Neural Calcium Binding

Proteins and Their Function

Guanylate Cyclase Activating Proteins

The Structure of Contractile Proteins

The Actin Component of Contractile Machinery of the

Cell

The Role of Thymosin Family Actin-Binding Proteins in Actin Dynamics

The Fimbrin Family of Actin-Binding Proteins

a-Actinin

Myosin Filaments

Troponins and Tropomyosins in the Regulation of

Muscle Cell Contraction

The Structure and Biology of Calbindin

Calbindin in Neuronal Populations

Neural Cell Lineage and the Regulation of Calbindin Expression

Calbindin Expression in Embryonic Development and Ageing

Physiological Function of Calbindin

Neuroprotective Function of Calbindin

Calbindin Expression and the Metastatic Phenotype

Calretinin: Its Role in Cell Differentiation and as a Potential

Tumour Marker

Calretinin and Its Alternatively Spliced Isoforms

Regulation of Calretinin Expression

Calretinin Expression in Cell Proliferation and Differentiation

Calretinin and Its Possible Neuroprotective Property

Calretinin as a Potential Tumour Marker

Calcineurin in Cell Proliferation, Cell Adhesion, and Cell Spreading

Molecular Features of Calcineurin

Calcineurin in Cell Proliferation and Adhesion-Related Phenomena

Calcineurin in Alzheimer's Disease

Calcineurin in Immunosuppression

Centrins (Caltractins) and Their Biological Functions

Reticulocalbin Family of EF-Hand Proteins

Molecular Features of Reticulocalbin Homologues

Putative Functions of Reticulocalbin and Its Homologues

Calpains in Normal and Aberrant Cell Physiology

The Calpain Family of Calcium-Binding Proteins

Molecular Organisation of Calpains

Regulation of Physiological Events by Proteolytic Function

Involvement of Calpains in Development and Differentiation

Calpains in Cell Proliferation and Apoptosis

Calpains in Cell Spreading and Migration

Calpains in Integrin-Mediated Cell Adhesion and Signal Transduction

Calpains in Cancer Growth and Progression

Calpains in Myelodegenerative Diseases

Calpains in Muscular Dystrophy

Caspases in Apoptosis, Cell Migration. Proliferation, and

Neoplasia

Caspases in Apoptotic Cell Death

Poly (ADP-Ribose) Polymerase as a Marker of Apoptosis

Caspase-Mediated Apoptosis and Cell Growth Inhibition in Tumour Expansion

Caspase-Mediated Proteolysis of Fodrin: Implications for Apoptosis, Cell Adhesion, Cell Migration, and Neoplastic Transformation

Caspases and Neuronal Loss in Alzheimer's Disease

Parvalbumins In Neuronal Development, Differentiation, and Proliferation

Osteonectin In Cell Function And Behavior

Molecular Structure of Osteonectin

Functions and Functional Domains of Osteonectin

Regulation of Osteonectin Expression

Osteonectin in the Remodeling of the Extracellular Matrix

Osteonectin in Embryonic Development and Differentiation

Modulation of Cellular Adhesion, Cell Shape, and Motility by Osteonectin

Modulation of Cell Proliferation by Osteonectin

Effects of Osteonectin on Angiogenesis

Osteonectin Expression in Cancer Development and Progression

Osteonectin Involvement in Other Disease States

Osteonectin Homologues and Their Putative Tumour Suppressor Properties

S100 Proteins: Their Biological Function And Role In

Pathogenesis

S100 Proteins in Cell Differentiation, Motility, and

Cancer Invasion

Effects of S100 Proteins in Cell Deformability and Cellular Morphology

S100A Isoforms

S100A2 As A Putative Tumour Suppressor

S100A3 Expression in Cell Differentiation and Neoplasia

S100A4 in Cancer Development and Progression

S100A6 (Calcyclin) in Cancer

The Biological Properties of S100A7 (Psoriasin)

Structure and Molecular Properties of S100A7

S100A8 and S100A9 Proteins in Inflammatory Diseases

S100A11 (S100C) and Possible Modes of Its Function

S100P in Cancer Progression

Potential Value of S100 Proteins As Markers of Cancer Progression and Prognosis

Epilogue

References

Index

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED062000
MEDICAL / Oncology
SCI017000
SCIENCE / Life Sciences / Cytology