Calcium Signalling in Cancer  book cover
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Calcium Signalling in Cancer




ISBN 9780849309427
Published November 29, 2000 by CRC Press
384 Pages 28 B/W Illustrations

 
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Book Description

Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feature of cell adhesion and motility; the integrity of the calcium binding proteins themselves is a basic requirement of normal biological function. In fact, the deregulation of calcium signaling is now regarded as the primary event in the pathogenesis, growth, invasion, and secondary spread of cancer.

Calcium Signalling in Cancer is a concise up-to-date treatise on the transduction signals induced by calcium that considers how alterations in this calcium-dependent signal transduction pathway are related to a number of human diseases, especially neoplastic transformation. This authoritative text examines a broad range of topics-from mechanisms and significance of calcium homeostasis for normal cell function to calcium signalling pathways and the transduction of the calcium signal, especially in proliferation, cell motility, cancer invasion,, and metastasis.

Clearly organized, it covers all aspects of the subject including specific sections on the regulation of the genes whose products are required for signal transduction by calcium, such as Alzheimer's disease, Darier's disease, Duchenne and limb girdle dystrophies, psoriasis and some forms of ichthyosis, and cancer associated retinopathy. With an extensive bibliography and over 2,500 references, Calcium Signalling in Cancer is an invaluable reference source.

Table of Contents

Preface

Abbreviations

Introduction

The Calcium Signalling Pathway
Homeostasis of Cell Calcium
Phospholipid Signalling
PTEN Phosphatase in the Regulation of Lipid
Signalling
The Protein Kinase C Pathway
Protein Kinase C and Its Isoforms in Signal
Transduction
Inositol Phosphates in Signal Transduction
Deregulation of Inositol 1,4,5-Trisphosphate Pathway
and Its Consequences
Ryanodine and Related Receptors in Calcium
Mobilisation
Cyclic AMP in Calcium Signalling
Architectural Aspects of the Signal Transduction
Machinery

Calcium Binding Proteins and Their Natural Classification
Non-EF-Hand Calcium Binding Proteins
Annexins
The Gelsolin Family Calcium Binding Proteins
Calreticulin and Its Functional Diversity
Calsequestrin and Intracellular Calcium Storage
Osteocalcin in Bone Metabolism and Osteotropism
of Cancer

The EF-Hand Calcium Binding Proteins
Molecular Organisation of Calcium Binding EF Hand
Proteins
Calcium Binding and the Molecular Configuration of
Calcium Binding Proteins
The Structure and Organisation of S100 Family
Genes
Alternatively Spliced Variants of S100A4
Functional Significance of Alternatively Spliced
Isoforms
Regulation of Expression of S100 Family Genes

The Calmodulin Family of Calcium Binding Proteins
Calmodulin and its Physiological Function
Recoverin Subfamily of Neural Calcium Binding
Proteins and Their Function
Guanylate Cyclase Activating Proteins

The Structure of Contractile Proteins
The Actin Component of Contractile Machinery of the
Cell
The Role of Thymosin Family Actin-Binding Proteins in Actin Dynamics
The Fimbrin Family of Actin-Binding Proteins
a-Actinin
Myosin Filaments
Troponins and Tropomyosins in the Regulation of
Muscle Cell Contraction

The Structure and Biology of Calbindin
Calbindin in Neuronal Populations
Neural Cell Lineage and the Regulation of Calbindin Expression
Calbindin Expression in Embryonic Development and Ageing
Physiological Function of Calbindin
Neuroprotective Function of Calbindin
Calbindin Expression and the Metastatic Phenotype

Calretinin: Its Role in Cell Differentiation and as a Potential
Tumour Marker
Calretinin and Its Alternatively Spliced Isoforms
Regulation of Calretinin Expression
Calretinin Expression in Cell Proliferation and Differentiation
Calretinin and Its Possible Neuroprotective Property
Calretinin as a Potential Tumour Marker

Calcineurin in Cell Proliferation, Cell Adhesion, and Cell Spreading
Molecular Features of Calcineurin
Calcineurin in Cell Proliferation and Adhesion-Related Phenomena
Calcineurin in Alzheimer's Disease
Calcineurin in Immunosuppression

Centrins (Caltractins) and Their Biological Functions
Reticulocalbin Family of EF-Hand Proteins
Molecular Features of Reticulocalbin Homologues
Putative Functions of Reticulocalbin and Its Homologues

Calpains in Normal and Aberrant Cell Physiology
The Calpain Family of Calcium-Binding Proteins
Molecular Organisation of Calpains
Regulation of Physiological Events by Proteolytic Function
Involvement of Calpains in Development and Differentiation
Calpains in Cell Proliferation and Apoptosis
Calpains in Cell Spreading and Migration
Calpains in Integrin-Mediated Cell Adhesion and Signal Transduction
Calpains in Cancer Growth and Progression
Calpains in Myelodegenerative Diseases
Calpains in Muscular Dystrophy

Caspases in Apoptosis, Cell Migration. Proliferation, and
Neoplasia
Caspases in Apoptotic Cell Death
Poly (ADP-Ribose) Polymerase as a Marker of Apoptosis
Caspase-Mediated Apoptosis and Cell Growth Inhibition in Tumour Expansion
Caspase-Mediated Proteolysis of Fodrin: Implications for Apoptosis, Cell Adhesion, Cell Migration, and Neoplastic Transformation
Caspases and Neuronal Loss in Alzheimer's Disease

Parvalbumins In Neuronal Development, Differentiation, and Proliferation
Osteonectin In Cell Function And Behavior
Molecular Structure of Osteonectin
Functions and Functional Domains of Osteonectin
Regulation of Osteonectin Expression
Osteonectin in the Remodeling of the Extracellular Matrix
Osteonectin in Embryonic Development and Differentiation
Modulation of Cellular Adhesion, Cell Shape, and Motility by Osteonectin
Modulation of Cell Proliferation by Osteonectin
Effects of Osteonectin on Angiogenesis
Osteonectin Expression in Cancer Development and Progression
Osteonectin Involvement in Other Disease States
Osteonectin Homologues and Their Putative Tumour Suppressor Properties

S100 Proteins: Their Biological Function And Role In
Pathogenesis
S100 Proteins in Cell Differentiation, Motility, and
Cancer Invasion
Effects of S100 Proteins in Cell Deformability and Cellular Morphology
S100A Isoforms
S100A2 As A Putative Tumour Suppressor
S100A3 Expression in Cell Differentiation and Neoplasia
S100A4 in Cancer Development and Progression
S100A6 (Calcyclin) in Cancer
The Biological Properties of S100A7 (Psoriasin)
Structure and Molecular Properties of S100A7
S100A8 and S100A9 Proteins in Inflammatory Diseases
S100A11 (S100C) and Possible Modes of Its Function
S100P in Cancer Progression
Potential Value of S100 Proteins As Markers of Cancer Progression and Prognosis

Epilogue

References

Index

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