These proceedings were published as a result of a workshop sponsored by the Chemoprevention Branch of the National Cancer Institute. The workshop covered a range of topics including calcium and vitamin D in human nutrition; epidemiologic relationships betweencalcium, vitamin D, and colon cancer; the biology of calium and vitamin D at the tissue and cellular level; and enimal and human studies investigating the potential for prevention of colon cancer with calcium and vitamin D.
1. Calcium and Vitamin D in Human Nutrition Robert P. Heaney, M.D., F.A.C.P. 2. Calcium Switches, Cell Cycles, Differentiation, and Death James F. Whitfield, Ph.D. Part 1: Epidemiology: Relationships Between Calcium and Vitamin D Intake and Colon Cancer 3. Colon Cancer Parallels Rickets Cedric F. Garland, Dr.P.H., Frank C. Garland, Ph.D., and Edward D. Gorham, M.P.H. 4. Calcium and Colon Cancer in Los Angeles County Ruth K. Peters, Sc.D., Thomas M. Mack, M.D., David H. Garabrant, M.D., David M. Homa, and Malcolm C. Pike, Ph.D. 5. Calcium and Colon Cancer in Utah Martha L. Slattery, Ph.D., M.P.H., and Ann W. Sorenson, Ph.D. Part 2: Biology of Calcium and Vitamin D at the Cellular and Tissue Level 6. Colonic Hyperplasia and Hyperproliferation Induced in Rodents by a Nutritional Stress Diet Containing 4 Factors of the Western Human Diet: High Fat and Phosphate, Low Calcium and Vitamin D (H.L. Newmark, M.S. and M. Lipkin, M.D.) 7. Use of Human Colonic Epithelial Cells in Tissue Culture to Study Mechanisms of Calcium Protection Eileen A. Friedman, Ph.D. 8. Discussion of Presentation by Dr. Gary Stoner Part 3: Animal Studies: Prevention of Colon Cancer with Calcium and Vitamin D 9. The Inhibitory Effect of Calcium on Colorectal Cytokinetics and Carcinogenesis R.C.N. Williamson, M.D., F.R.C.S., M.G. Thomas, Ch.M., F.R.C.S., and G.V.N. Appleton, Ch.M., F.R.C.S. 10. Calcium and Vitamin D Effects on Tumor Promotion in Rat Colon and Mouse Skin Barbara C. Pence, Ph.D. 11. Effects of Bile Acids and Sterols on Animal Models of Colorectal Cancer Bertram I. Cohen, Ph.D. and Erwin H. Mosbach, Ph.D. 12. Dietary Calcium, Phosphate and Vitamin D in Relation to Mammary Carcinogenesis Kenneth K. Carroll, Ph.D., Lisa A. Eckel, H.B.S.C., Laurence J. Fraher, Ph.D., Jaroslav V. Frei, M.D., Ph.D., F.R.C.P. (c), and Harold Newmark, M.S. 13. Effect of Dietary Calcium on Azoxymethane-Induced Intestinal Carcinogenesis in Male F344