This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine.
The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.
Table of Contents
Personalized Medicine for Cancer: Introduction and Overview of the Book
Il-Jin Kim and David Jablons
Personalized Medicine in Lung Cancer
Daniela Morales-Espinosa, Silvia García-Román, and Rafael Rosell
Genome-Based Personalized Medicine in Liver Cancer
Jae-Jun Shim and Ju-Seog Lee
Applications of Circulating DNA Analysis in Personalized Medicine
Dana W. Y. Tsui and Muhammed Murtaza
Circulating Tumor Cells and Personalized Medicine
Jin Sun Lee, Mark Jesus M. Magbanua, Marc R. Jabon, and John W. Park
Mouse Models in Personalized Cancer Medicine
M. E. Beaulieu, T. Jauset, D. Massό-Vallés, L. Soucek, and J. R. Whitfield
Tumor Microenvironment, Therapeutic Resistance, and Personalized Medicine
Personalized Immune Therapy
Joost Hegmans, Lysanne Lievense, and Joachim Aerts
Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Peritoneal Malignancies
G. E. Bates, P. Kim, C. M. DeRosa, L. Petrukhin, Y. Bressler, and R. N. Taub
Personalized Medicine in Hereditary Cancer Syndromes
Rishi Agarwal and Vivek Subbiah
Pathology in the Era of Personalized Medicine
Hye Seung Lee
MicroRNAs in Human Cancers
Tae Jin Lee and Carlo M. Croce
Pharmacogenomics of Tamoxifen
Il-Jin Kim is principal investigator and director of Applied Genomics in the UCSF Thoracic Oncology Program. His work focuses on the identification of novel therapeutic targets and diagnostic markers for various types of human cancers. Dr. Kim investigates human cancers using state-of-the-art technologies, including next-generation sequencing (NGS) and system genetic tools that he developed with his team. He has developed several innovative microarrays and pioneered new methods of high-throughput mutation screening, for which he holds numerous patents. He has published more than 70 papers, including in Science and Nature Communications. He has also received three awards from the American Association for Cancer Research for developing innovative genetic and diagnostic assays.
"Likely as the recent Cancer Moonshot Initiative highlights, this book well describes the importance of genetics/genomics-based personalized therapies to improve cancer treatments. This field is growing rapidly, and it is certain that many scientists should obtain professional knowledge of ‘cancer precision medicine’ to cure more cancer patients."
—Prof. Yusuke Nakamura, University of Chicago, USA
"At a time when an explosive increase in data has combined with rapidly evolving treatment paradigms, it has become particularly challenging for modern clinicians and medical researchers alike to put these advances in knowledge and practice into a proper context. It is in light of this predicament that this new volume edited by Dr. Il-Jin Kim provides a much-needed organization and harmonic understanding to the cacophony of information regarding the elusive realm of precision medicine. Covering an exhaustive array of topics ranging from the basic science of tumor modeling to the biology of tumor microenvironments to the horizon of cancer immunotherapy and advances for specific cancer types, this clearly written and very readable compilation provides a solid foundation for comprehending the rapidly advancing dawn of a truly new, personalized, precision approach to the treatment and, hopefully, the cure of cancer."
—Prof. Michael J. Mann, University of California, San Francisco