Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research.
Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.
Part 1: Radiobiology, Radiation Physics, and Dosimetry 1. Medical Internal Dosimetry for High-Dose Radionuclide Therapies D.R. Fisher 2. Radiolabeled Antibody Tumor Dosimetry D.J. Buchsbaum and B.W. Wessels 3. Radiobiology and Radioimmunotherapy: Implications for Clinical Applications J.R. Williams, R.R. Mayer, Y. Zhang, S.M. Quadri, and L.E. Dillehay Part 2: Radiochemistry of Therapeutic Radionuclides 4. Radiochemistry of Therapeutic Radionuclides G.L. Griffiths 5. Advanced Methods for Rabiolabeling Monoclonal Antibodies with Therapeutic Radionuclides O.A. Gansow and C. Wu 6. Antibody Radiolabeling with Isotopes of Rhenium, G.L. Griffiths Part 3: Targeting, Pharmacokinetics, and Experimental Radioimmunotherapy 7. Pharmacokinetics of Antibodies and Their Radiolabels M.J. Mattes 8. Development of Cancer Radioimmunotherapy and Its Potential Use as an Adjuvant Treatment R.M. Sharkey, R.D. Blumenthal, and D.M. Goldenberg 9. Experimental Radioimmunotherapy and Methods to Increase Therapeutic Efficacy, D.J. Buchsbaum Part 4: Clinical Radioimmunotherapy 10. Overview of Obstacles and Opportunities for Radioimmunotherapy of Cancer G.L. DeNardo and S.J. DeNardo 11. Radioimmunotherapy of Ovarian Cancer A. Maraveyas and A.A. Epenetos 12. Radioimmunotherapy of Colorectal Cancer J.L. Murray 13. Radioimmunotherapy in the Treatment of Metastatic Breast Cancer: An Overview, S.J. DeNardo 14. Radioimmunotherapy of CNS Malignant Gliomas by Direct Intralesional Injection of Specific 131I Radiolabeled Monoclonal Antibodies, P. Riva et al. 15. Treatment of B-Lymphocyte Malignancies with 131I-Lym-1 and 67Cu-2IT-BAT-Lym-1 and Opportunities for Improvement G.L. DeNardo and S.J. DeNardo 16. Treatment of Relapsed B Cell Lymphomas with High-Dose Radioimmunotherapy and Bone Marrow Transplantation O.W. Press, J.F. Eary, F.R. Appelbaum