806 Pages 48 Color & 21 B/W Illustrations
    by Apple Academic Press

    Extensive attempts for developing cancer vaccines over the last 50 years have been made, but with minimal success. The current research in genetics, molecular biology, biochemistry, and immunology has revived interest in these immunotherapies and enabled the development of potential cancer vaccine candidates. This book, Cancer Vaccination and Challenges, in two volumes, deals with the very relevant issue of cancer vaccines and the various challenges their development and delivery present.

    Volume 1: Different Strategies for Therapeutic Cancer Vaccine Development deals with different strategies of cancer vaccine development. The primary focus of this volume is the techniques for the development of therapeutic cancer vaccines. It helps clarify the current need for vaccines in cancer treatment, exploring deeper information such as the roles of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management. The volume also provides latest insights on DNA- and RNA-based cancer vaccines, eventually covering the regulatory perspectives for the cancer vaccine developments.

    Volume 2: Delivery Strategies for Cancer Vaccine and Immunotherapy in Management of Various Carcinomas presents an understanding of delivery strategies of cancer vaccines for the management of various forms of carcinoma. It discusses the management of various carcinomas using vaccines, examining the prospects of delivering immuno-oncology therapies, focusing specifically on the affective drug delivery strategies for treatment of lung, prostate, and pancreatic carcinomas. The volume provides an overview of the current vaccine systems, adjuvants, and delivery methods that are being explored or have been approved. It also focuses on therapeutic cancer vaccines that could be used to prevent the spread of advanced malignancies that are resistant to standard treatments, including surgery, radiation therapy, and chemotherapy.

    This two-volume book will be a valuable resource for researchers with a pharmaceutical background and professionals working in the field of biomedical science, engineering, vaccine development, and cancer therapy.

    VOLUME 1: DIFFERENT STRATEGIES FOR THERAPEUTIC CANCER VACCINE DEVELOPMENT

    1. Cancer Vaccines: Types, Mechanisms, and Recent Developments

    Lucy Mohapatra, Deepak Mishra, Alok Shiomurti Tripathi, and Sambit Kumar Parida

    2. Strategies to Develop Cancer Vaccines

    Patel Dhaval J., Chaudhary Sunita A., Chaudhary Ankit B., and Prajapati Bhupendra G.

    3. Role of Tumor Antigens for Cancer Vaccine Development

    Himanshu Sharma, Rashmi Pathak, Neetu Sachan, and Phool Chandra

    4. DNA-Based Cancer Vaccine: Advancements and Challenges

    Sagar Pandav, Vipul P. Patel, Arde Gayatri, and Bhupendra Prajapati

    5. RNA-Based Cancer Vaccines: Advancements and Challenges

    Palak A. Shah, Rashmi A. Shukla, Mehul R. Chorawala, Nimisha P. Kakadia, Bhupendra Prajapati, and Shrikalp S. Deshpande

    6. Utilization of Microbial Genes as a Vaccine Against Cancer

    Garima Varshney, Rishabha Malviya, Sonali Sundram, and Dhanalekshmi Unnikrishnan Meenakshi

    7. Utilization of Protein and Peptides as Cancer Vaccines: Advancements and Challenges

    Patel Gayatri and Patel Priya

    8. Stem Cell-Based Cancer Vaccines as Promising Immunotherapy: Current Progress and Challenges

    Mehul R. Chorawala, Humzah Postwala, Yesha Shah, Palak Shah, Bhupendra Prajapati, and Vishvas N. Patel

    9. Preventive Cancer Vaccines

    Sachin P. Bhatt, Avani N. Joshi, and Bhupendra G. Prajapati

    10. Providing Cognitive Platforms for the Effectiveness of Cancer Vaccines

    Zahra Alidousti Shahraki and Mohsen Aghabozorgi Nafchi

    11. Survival Data and Therapeutic Outcomes of Cancer Vaccines

    Patel Priya, Prajapati Bhupendra, and Patel Gayatri

    12. Regulatory Considerations for Cancer Vaccines Development

    Shivani N. Jani, Hitesh B. Katariya, and Bhupendra G. Prajapati

    VOLUME 2: DELIVERY STRATEGIES FOR CANCER VACCINES AND IMMUNOTHERAPY IN THE MANAGEMENT OF VARIOUS CARCINOMAS

    1. Delivery Systems for Cancer Vaccines

    Sapna Rathod, Nisarg Patel, and Bhupendra Prajapati

    2. Current Knowledge and Prospects of Various Vaccine Delivery Systems for Lung Cancer Treatment

    Ritika Singh and Chanchal Deep Kaur

    3. Advanced Drug Delivery System for Targeting Carcinomas

    Hitesh Malhotra, Sweta Kamboj, Ashna Gupta, Kartik Babbar, and Rupesh Gautam

    4. Correlation Between Cancer Vaccines and Immunity

    Neelakanta Sarvashiva Kiran, Chandrashekar Yashaswini, Gaonkar Lowkesh, and Bhupendra G. Prajapati

    5. Cancer Vaccines for Lung Cancer

    Ankita Panigrahi, Mythreyi R., Gopenath Ts, Kanthesh M. Basalingappa, and Gobianand K.

    6. Synergistic Effect of Vaccines and Chemotherapeutic Agents in Combating Different Carcinomas

    Hitesh Malhotra, Rohit Kamboj, Amrit Sarwara, Sumit Arora, and Rupesh K. Gautam

    7. Cancer Immunotherapy Using mRNA

    Umang Shah, Aashka Thakkar, Alkesh Patel, Sandip Patel, Mehul Patel, and Rajesh Maheshwari

    8. Autologous Vaccines for Prostate and Pancreatic Cancer

    Nayankumar C. Ratnakar, Beenkumar R. Prajapati, and Bhupendra G. Prajapati

    9. Combined Therapy of Cancer with Vaccines and Chemotherapeutic Agents

    Dipa K. Israni and Ramesh K. Goyal

    10. Role of Various Cancer Vaccine Adjuvants in Cancer Management

    Nazneen Siddique, Himanshu Solanki, Brijesh Parlekar, and Bhupendra Prajapati

    11. Combined Therapy of Cancer with Vaccines and Chemotherapeutic Agents

    Alkeshkumar Patel, Samir Patel, Sanika Dongre, Priyanka Srivastava, Hemangini Vora, Dhruti Patel, and Krishna Jani

    Biography

    Rishabha Malviya, PhD, has 11 years of research experience and is presently working as Associate Professor in the Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India. His areas of interest include formulation optimization, nanoformulation, targeted drug delivery, localized drug delivery, and characterization of natural polymers as pharmaceutical excipients. He has authored more than 150 research and review papers for national and international journals of repute. He holds over 50 patents and has published many papers in reputed national and international journals, for which he received an outstanding reviewer award from Elsevier. He has edited 13 books (Wiley, Springer Nature, CRC Press/Taylor and Francis, Apple Academic Press, River Publisher, Lambert, and OMICS Publishing Group) and authored 15 book chapters. His name has been included in the World’s Top 2% Scientists list by Elsevier BV and Stanford University. He is reviewer, editor, and editorial board member of more than 50 national and international journals. He was an invited author for the magazine Atlas of Science as well as a pharma magazine dealing with B2B industry, Ingredient South Asia. He completed his BPharm at Uttar Pradesh Technical University and MPharm (Pharmaceutics) at Gautam Buddha Technical University, Lucknow, Uttar Pradesh. His PhD (Pharmacy) work was in novel formulation development techniques.

    Bhupendra Prajapati, PhD, is a Professor in the Department of Pharmaceutics, Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Gujarat, India. He has more than 20 years of academic and research experience and has published more than 100 research and review papers in international and national journals. He has edited three books and has authored 20 book chapters in the field of novel drug delivery. He has published two Indian patents and has three applications under evaluation. He is a reviewer for three high impact journals and is on the editorial boards of several scientific journals.

    Sonali Sundram, PhD, is Assistant Professor in the School of Medical & Allied Sciences at Galgotias University, Greater Noida, Uttar Pradesh, India. Previously, she worked as a research scientist on a project of ICMR at King George’s Medical University, Lucknow, India. After that, she joined BBDNIIT (Babu Banarasi Das Northern India Institute of Technology), Lucknow. Her PhD (Pharmacy) work was in neurodegeneration and nanoformulation. Her areas of interest include neurodegeneration, clinical research, and artificial intelligence. She has edited four books (Wiley, CRC Press/Taylor and Francis, River Publisher) and has organized more than 15 national and international seminars, conferences, and workshops. She has more than eight patents, both national and international, to her credit. She completed both BPharm and MPharm (Pharmacology) from Dr. A.P.J. Abdul Kalam Technical University, Lucknow, India.

    “A comprehensive guide to cancer vaccine research. . . . cover[s] every aspect of cancer immunology and vaccine development . . . and explores the most successful and promising approaches by incorporating the latest studies on preventive and therapeutic cancer vaccination. The book offers up-to-date information on various topics, including tumor antigens for cancer vaccines, strategies, approaches, advancements, difficulties, and challenges in vaccine development for cancer treatment. Recent advances in DNA and RNA-based vaccines for cancer prevention and treatment are thoroughly discussed in this volume. This compendium enables researchers and practitioners to easily access the comprehensive concept of cancer vaccines and their implications in healthcare. . . . An essential resource in disseminating the vast and expanding literature on cancer immunization and vaccine development.”
    —From the Foreword by Harish Padh, Former Vice-Chancellor, Sardar Patel University, Vallabh Vidyanagar, Anand, Gujarat, India; Former Director, B. V. Patel Pharmaceutical Education and Research Development (PERD), Ahmedabad, Gujarat, India