Cancer and the Search for Selective Biochemical Inhibitors: 2nd Edition (Hardback) book cover

Cancer and the Search for Selective Biochemical Inhibitors

2nd Edition

By E.J. Hoffman

CRC Press

480 pages | 4 B/W Illus.

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Hardback: 9781420045932
pub: 2007-06-25
eBook (VitalSource) : 9780429143922
pub: 2007-06-25
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The world of medicine has become splintered into two factions, that of orthodoxy and its counterpart, alternative or complementary medicine. A problem with alternative medicine is, of course, that of anecdote and hearsay. The solution: the disclosure, in an unassailable fashion, of the underlying biochemical principles for alternative cancer therapies.

Cancer and the Search for Selective Biochemical Inhibitors, Second Edition delineates the underlying biochemical principles for alternative cancer therapies. Completely revised and updated, this edition includes coverage of the link between concepts and practices of alternative and conventional medicine. The author examines anticancer plant substances and other alternatives such as Vitamin C, essiac tea, shark cartilage, and cat’s claw. The text also addresses the problem of determining selective and non-toxic enzyme inhibitors for cancer cell metabolic pathways.

While an increased number of allopathic professionals are in tune with alternative therapies, the integration of the two factions is far from the norm. Keeping the same format that made its predecessor a benchmark text, this book compares complementary, alternative, and integrative treatments with chemotherapy and other more traditional treatments.

Table of Contents



The Nutritional Brouhaha

The Ponderables of Biochemistry

Troubles of Mind

What Seems to Work

Scourges in the Making

Remedies in Nature

Poisons in Nature

From the Ordinary to the Bizarre

The Environment, Naturally and Not So Naturally

Where to from Here?

Cancer Origins and Characteristics


Cancer Formation and Oncogenes

Types of Cancers


Viral or Microbial Origins and Treatments

Viruses and Lysogeny

Viruses and Subviruses

Antiviral Agents

Immune Reactions


Biochemical Insights

The Warburg Cancer Theory

Cell Metabolism

Enzyme-Catalyzed Metabolic Pathways

Overall Glycolytic Conversions

Cancer Cell Metabolism vs. Normal Cell Metabolism

Selective Biochemical Inhibitors

The Tricarboxylic Cycle and Respiration

Vitamins and Hormones as Inhibitors or Promoters

Chemotherapy Drugs as Enzyme Inhibitors

More on Folic Acid

Enzyme Transformations

Starting at the Genetic Level

DNA, RNA, and Protein Synthesis

The Ubiquitous Roles of Proteins

Genetics as Science

Digestive Processes

Proteases and Their Inhibitors

Protein Degradation Rates

The Influence of Antibiotics

DNA Replication and Alteration



Enzymatic Biochemical Treatment Protocols


Enzyme Inhibitors

Enzyme Inhibition in Modern Medicine

Enzyme Inhibitors for Melanoma


Dietary Extremes

Iron in the Diet

Garlic and Allicin and Other Sulfur-Containing Compounds as Anticancer Agents



Cancer Markers

High-Tech vs. Low-Tech

Footdragging on Using Enzyme Inhibitors

The Alternative Scene

An Introduction to Alternatives

Some Alternatives, Information Sources, and Assessments

More About the Plant World

Poisonous and Medicinal Plants

Plants and Herbs as Agents Against Other Diseases


The Nitrogen Connection and Immunotherapy

Alkaloids and Bioactivity

Microorganisms and Immunity

In Short Summary

Surveying Anticancer Plant Substances

Status of Plants Against Cancer

Laetrile Quandaries

Plants of the American West and Southwest


Other Plants and Herbs

South Africa


Soviet Union



Egypt and Israel

United States

Great Britain

Still Other Options

Mystique Surrounding Cancer Cures


Neo Tropica

Some Further Alternatives

Successes vs. Failures

Biological Response

On Overcoming the Intractability of Cancer

Cell Resistance and Some Consequences

Alternative Treatment: The Status Quo


Heroic Efforts

More about Compound-X and the Like

An Update on News and Views

Cancer Directives

The Continuing Legacy of Wayne Martin and Compatriots

More of the Latest on Alternatives



Subviral Agents: Prions

More on DNA

More on Diet

The Navajo and Cancer

Cancer Esoterica

The Morphism of Cancer Cells

Electromagnetic Phenomena and Cancer

Some Inexplicables

Metastasis, Resistance, and Aberrations

More on Immunity


The Halogens and Cause and Cure

The Effect of Toxins in the Environment

More on Chemotherapy, Alkaloids, and Other Plant Biochemicals


Circling the Wagons

More on Genetic Modification or Engineering

Vaccination and Cancer

Telomerase Inhibitors

Histone Diacetylase Inhibitors

Markers for Monitoring Cancer Growth and Remission

Moral and Ethical Quandaries

The Inhibition of Cancerous Stem Cells

The Subject of Stem Cells and Cancer

Cancerous Stem Cells and Immunity

Inhibition of Cancerous Stem Cells

Tyrosine Kinase

Plant Sources for Tyrosine Kinase Inhibitors

A Summing Up


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Alternative Medicine
MEDICAL / Biochemistry
MEDICAL / Oncology