1st Edition
Cannabis Therapeutic Potential, Secondary Metabolites, Toxicity, and Regulations
Foreword
Preface
GENERAL OVERVIEW AND CULTIVATION
Introduction to Cannabis: History and Global Usage
Rishabh Agade, Ujban Hussain, Aditya Wadalkar, Divya Zambre, Veena S. Belgamwar and Prashant Puranik
The Current State of Cannabis in the Asia-Pacific Region
Rishabh Agade, Ujban Hussain, Aditya Wadalkar, Shweta Jaiswal, Veena S. Belgamwar and Prashant Puranik
Cannabis Cultivation for the Production of Secondary Metabolites: Agronomic Practices, Phytochemical Profiling, and Post-Harvest Processing
Francisco Mayron de Sousa e Silva, Sara da Silva Lima, Paulo Jordão de Oliveira Cerqueira Fortes, Jamila Ferreira Rocha, Maurício Pires de Moura do Amaral, Salomon Tinman and Livio Cesar Cunha Nunes
Cannabis From Farm to Pharmacy
Juliane M. S. Silva, Silvânia N. A. Lima, Enaianny R. S. Frankenberger, Carla F. C. Rodrigues, Tarcísio C. L. Araújo, Cristiane dos S. C. Alves, João V. M. Silva, Pedro G. S. Sá, Pedro J. Rolim-Neto and Larissa A. Rolim
SECONDARY METABOLITES AND THERAPEUTIC POTENTIAL
Secondary Metabolites in Cannabis sativa
Illa Fernanda Mesquita Silva, Herbert Gonzaga Sousa, Natasha Alves Rocha, Penina Sousa Mourão, Wellington Silva Aguiar, Isaac Bruno Paz Santos, Patrícia e Silva Alves, Rosemarie Brandim Marques and Valdiléia Teixeira Uchôa
Non-Cannabinoid Metabolites of Cannabis sativa in Therapy
Sabrin R. M. Ibrahim, Mahmoud A. Elfaky, Gamal A. Mohamed and Hossam M. Abdallah
Impact of Cannabinoids on Sleep
Estefanía Butassi, Melina Di Liberto, Alan Blanc, Luz Rivero Márquez, Estefanía Cordisco, Maximiliano Sortino and Laura Svetaz
Cannabis as Medicine: Clinical Trials and Applications
Renata da Silva Carneiro, Felipe Alves Batista, Michelle Vicente Torres, José Zilton Lima Verde Santos and Anderson Nogueira Mendes
Action of Cannabis Constituents in the Modulation of Oxidative Stress and Inflammation
Lívia Alves Figueiras, Mateus Henrique de Almeida da Costa, Francisco das Chagas Pereira de Andrade, Maria Hillana Nunes and Anderson Nogueira Mendes
Unlocking the Hidden Power: Chemical and Biological Insights Into Cannabis sativa Roots
Melina Di Liberto, Estefanía Butassi, Alan Blanc, Luz Rivero Márquez, Estefanía Cordisco, Laura Svetaz and Maximiliano Sortino
Metabolic Health and the Therapeutic Potential of Cannabis sativa: Insights Into Obesity, Diabetes, Dyslipidemia, and Hypertension
Lucas Rannier Ribeiro Antonino Carvalho, Débora Gonçalves Paiva, Januse Míllia Dantas de Araújo and Jailane de Souza Aquino
TOXICITY AND RISK ASSESSMENT
Risks and Benefits of Cannabis and Cannabinoids in Psychiatry
Paulo Sousa Lima Junior, Melciades Norberto, Italo Moita and Chistiane M. Feitosa
Cannabis Use and the Risk of Psychosis or Schizophrenia
Shweta Jaiswal, Divya Zambre, Pavan Ugalmugale, Rishabh Agade, Bhagyashree Kokate and Veena S. Belgamwar
Cannabis and Pregnancy: Implications for Maternal and Child Health
Bhagyashree Kokate, Swati Bodhankar, Deepali Chaudhary and Veena S. Belgamwar
REGULATIONS AND SOCIO-ECONOMIC PERSPECTIVES
Regulations, Legalization, and Social Impact
Marcília Pinheiro da Costa, Marcia dos Santos Rizzo, Valéria Carlos de Sousa, Igor Frederico da Silveira Ramos and Talissa Brenda de Castro Lopes
Global Cannabis Policies and Regulatory Frameworks: A Comparative Overview
Pedro Vitor Oliveira Silva Furtado, João Paulo da Silva Gomes, Juliana de Sousa Figuerêdo, Patrícia e Silva Alves, Maria Gabryella Castro Moita, Maria das Dores Alves de Oliveira and Chistiane Mendes Feitosa
Cannabis in the Socio-Economic Context of the Southern Mid-Himalayas
Bijay Raj Subedee and Shandesh Bhattarai
Index
Editors Biography
Biography
Dr. Mahendra Rai is presently a senior visiting Professor at the Department of Chemistry, Federal University of Piaui (UFPI), Teresina, Brazil. Formerly, he was a Professor and Head of the Department of Biotechnology at SGB Amravati University in Maharashtra, India. He has also held positions as a visiting scientist at several prestigious institutions, including the University of Geneva, Debrecen University in Hungary, the University of Campinas in Brazil, VSB Technical University of Ostrava in the Czech Republic, the National University of Rosario in Argentina, and the University of São Paulo. Dr. Rai has an impressive publication record, with over 450 research papers published in national and international journals with 95 h-index. In addition, he has edited/authored more than 70 books and holds six patents. Notably, he has recently been featured in Stanford’s list of the top 2% of scientists in nanoscience and nanotechnology, and ranks 7th nationally in biology and biochemistry, according to Research.com.
Dr. Chistiane M. Feitosa is a Professor of Chemistry at the Federal University of Piauí (UFPI), Teresina, Brazil. She specializes in Natural Products Chemistry, with research interests in acetylcholinesterase enzyme bioassays, antioxidants, medicinal plants (extracts, secondary metabolites, and essential oils), and Alzheimer’s disease.
She was awarded the CNPq Technological Productivity Scholarship (2012–2015) for her scientific contributions. At UFPI’s Teresina campus, Dr. Feitosa teaches in the Chemistry Master’s program and in Pharmaceutical Sciences, with a focus on the production and quality control of medicines.
She has published more than 75 scientific articles and over 10 books in English and Portuguese. In addition, she serves as an active peer reviewer for several international journals, including the Brazilian Journal of Pharmacognosy, Pharmaceutical Biology, and the Journal of Medicinal Plants Research.






