Carbon Nanotubes: From Bench Chemistry to Promising Biomedical Applications, 1st Edition (Hardback) book cover

Carbon Nanotubes

From Bench Chemistry to Promising Biomedical Applications, 1st Edition

Edited by Giorgia Pastorin

Jenny Stanford Publishing

156 pages | 83 Color Illus. | 56 B/W Illus.

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pub: 2011-01-31
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Description

This book represents a critical evaluation of the most recent discoveries about carbon nanotubes and includes a cautious description of their impact on personal health and environmental pollution. It also offers an overview of the main research groups around the world which have been focusing their efforts on the exploitation of this intriguing material, with the purpose of inspiring young scientists to follow their pathway.

Reviews

"This unique book comes at the right time when the scientific community and numerous organizations are divided on the potential applicability of carbon nanotubes. A concentrate of the most recent scientific discoveries written by highly recognized authors in the field. An excellent reference for inspiring scientists and students."

—Dr. Sylviane Muller, CNRS, France

"This book represents an extensive collection of the most updated studies that encourage the use of carbonbased nanostructures for biomedical applications. At the same time, the reader is cautioned about the potentially hazardous factors and the mischievous surprises associated with carbon nanotubes. This is a very interesting book, especially for young scientists seeking inspiration from the most fascinating discoveries in the field of nanotubes reported by selected research groups all over the world!"

—Prof. Hans E. Junginger, Naresuan University, Thailand

"This book offers the perspectives of both an enthusiastic acceptance of carbon nanotubes for biomedical applications and also the distrustful vision due to potential hazardous consequences deriving from their unpredictable effects. Much remains to be learned about this nanomaterial before its most effective applications and preventions of any untoward effect."

—Prof. Dusica Maysinger, McGill University, Canada

Table of Contents

Contributors

Preface

Stabilisation of Carbon Nanotube Suspensions Dimitrios G. Fatouros, Marta Roldob and Susanna M. van der Merwe

Introduction

Functionalised CNTs for Drug Delivery

Surface-Active Agents in Stabilising CNT Suspensions

Stabilisation of Aqueous Suspensions of Carbon Nanotubes by Self-Assembling Block Copolymers

Stabilisation of Aqueous Suspensions of Carbon Nanotubes by Chitosan and its Derivatives

Biomedical Applications I: Delivery of Drugs Giampiero Spalluto, Stephanie Federico, Barbara Cacciari, Alberto Bianco, Siew Lee Cheong and Maurizio Prato

Introduction

Non-Covalent Functionalisation on the External Walls

"Defect" Functionalisation at the Tips and Sidewalls

Covalent Functionalisation on the External Sidewalls

Encapsulation Inside CNTs

Conclusions and Perspectives

Biomedical Applications II: In_luence of Carbon Nanotubes in Cancer Therapy Chiara Fabbro, Francesca Maria Toma and Tatiana Da Ros

Importance of Nanotechnology in Cancer Therapy

Carbon Nanotubes: A Brief Overview

Carbon Nanotubes as Drug Vectors in Cancer Treatment

Delivery of Oligonucleotides Mediated by Carbon Nanotubes

Carbon Nanotubes in Radiotherapy

Carbon Nanotubes in Thermal Ablation

Biosensors Based on Carbon Nanotubes

Conclusions

Biomedical Applications III: Delivery of Immunostimulants and Vaccines Li Jian, Gopalakrishnan Venkatesan and Giorgia Pastorin

Introduction to the Immune System

Immunogenic Response of Peptide Antigens Conjugated to Functionalised CNTs

Interaction of Functionalised CNTs with CPG Motifs and Their Immunostimulatory Activity

Immunogenicity of Carbon Nanotubes

Conclusions

Biomedical Applications IV: Carbon Nanotube–Nucleic Acid Complexes for Biosensors, Gene Delivery and Selective Cancer Therapy Venkata Sudheer Makam, Jason Teng Cang-Rong, Sia Lee Yoong and Giorgia Pastorin

Introduction

Interaction of CNTs with Nucleic Acids

Sensors and Nanocomposites

CNT–Nucleic Acid Complexes for Gene Delivery and Selective Cancer Treatment

Biomedical Applications V: In_luence of Carbon Nanotubes in Neuronal Living Networks Cecilia Menard-Moyon

Introduction

Effects of Carbon Nanotubes on Neuronal Cells’ Adhesion, Growth, Morphology and Differentiation

Electrical Stimulation of Neuronal Cells Grown on Carbon Nanotube-Based Substrates

Investigation of the Mechanisms of the Electrical Interactions Between CNTs and Neurons

Conclusions and Perspectives

Biomedical Applications VI: Carbon Nanotubes as Biosensing and Bio-interfacial Materials Yupeng Ren

Introduction

Biosensor

Bio-interface

Conclusions

Toxicity of Carbon Nanotubes Tapas Ranjan Nayak and Giorgia Pastorin

Introduction

Parameters Responsible for the Toxicity of CNTs

Environmental Exposure

Conclusion

Overview on the Major Research Activities on Carbon Nanotubes being done in America, Europe and Asia Cecilia Menard-Moyon and Giorgia Pastorin

Introduction

America

Europe

Asia

Index

About the Editor

Giorgia Pastorin received her MSc (110/110 cum laude) in pharmaceutical and chemistry technologies in 2000 and her PhD in 2004 from the University of Trieste, Italy. She then moved to France for two years of postdoctoral fellowship at the National Centre for Scientific Research (CNRS) in Strasbourg, where she acquired some skills in drug delivery under the supervision of Dr Alberto Bianco. She joined the National University of Singapore in June 2006 as assistant professor in the Department of Pharmacy.

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
SCI086000
SCIENCE / Life Sciences / General
TEC021000
TECHNOLOGY & ENGINEERING / Material Science