1st Edition

Carcinogenicity Testing: Predicting, and Interpreting Chemical Effects

By Kirk T. Kitchin Copyright 1998
    918 Pages
    by CRC Press

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    Offers comprehensive coverage of currently available cancer predictors, the most recent research on carcinogenicity, and the design and interpretation of carcinogenicity experiments. Presents mouse, rat, and human carcinogenicity data for the liver, kidney, breast, cervix, prostate, hematopoietic system, colon, skin, urinary bladder, mouth, stomach, thyroid, and pancreas.

    Testing Carcinogenicity

    The Cancer Bioassay, Paul Grasso and Shirley Price
    Value, Validity, and Historical Development of Carcinogenesis Studies for Predicting and Confirming Carcinogenic Risks to Humans, James Huff
    The Maximum Tolerated Dose and Secondary Mechanisms of Carcinogenesis, James S. MacDonald and Harvey E. Scribner
    Mouse Liver Carcinogenesis, Thomas L. Goldsworthy, Elizabeth H. Romach, and Tony R. Fox
    Information Sources on the Carcinogenicity of Chemicals, Kirk T. Kitchin

    Predicting Carcinogenicity

    Use of Mutagenicity for Predicting Carcinogenicity, David M. DeMarini
    Improved Predictivity of Chemical Carcinogens: The Use of a Battery of SAR Models, Orest T. Macina, Ying Ping Zhang, and Herbert S. Rosenkranz
    The ke Test, George Bakale
    Gap Junctional Intercellular Communication as a Method to Detect and Predict Carcinogenicity, Vladimir Krutovskikh and Hiroshi Yamasaki
    Predicting Chemical Carcinogenicity by In Vivo Biochemical Parameters, Kirk T. Kitchin and Janice L. Brown
    Liver Pyruvate Kinase as a Predictor of Promotion of Hepatocarcinogenesis, Susumu Yanagi
    Predicting Carcinogenicity: Peroxisome Proliferators, Jonathan D. Tugwood and Clifford R. Elcombe
    The Rat Liver Hepatocellular-Altered, Focus-Limited Bioassay for Chemicals with Carcinogenic Activity, Gary M. Williams and Harald Enzmann
    Transgenic Animals as Predictive Models for Identifying Carcinogens, William C. Eastin and Raymond W. Tennant

    Interpreting Carcinogenicity: Organs with High Animal and Low Human Cancer Rates

    Human Liver Carcinogenesis, Wai Nang Choy
    Comparative Kidney Carcinogenesis in Laboratory Rodents and Humans, Gordon C. Hard
    Forestomach and Glandular Stomach Carcinogenesis, Masao Hirose and Nobuyuki Ito
    Thyroid Carcinogenesis, Geraldine Anne Thomas

    Interpreting Carcinogenicity: Organs with High Animal and High Human Cancer Rates

    Lung Carcinogenesis, F. F. Hahn
    Mammary Cancer, Minako Nagao and Takashi Sugimura
    Cancers of the Hematopoietic System in Rodents and Humans: Chemical Factors, Physical Factors, and Molecular Epidemiological Studies, Elizabeth W. Newcomb
    Urinary Bladder Cancer, Shoji Fukushima, Hideki Wanibuchi, and Shinji Yamamoto
    Cancers of the Oral Cavity, Dhananjaya Saranath
    Reactive Intermediates and Skin Cancer, Moushumi Lahiri, Hasan Mukhtar, and Rajesh Agarwal

    Interpreting Carcinogenicity: Organs with Low Animal and High Human Cancer Rates

    Prostate Cancer, Maarten C. Bosland
    Exocrine Pancreatic Cancer, H. B. Bueno-de-Mesquita, Marko Jan Appel, Henk J. van Kranen, and Ruud A. Woutersen
    Colorectal Cancer, Gabriel A. Kune and Luis Vitetta
    Cervix Uteri and Uterus Cancer, Marios Marselos

    Interpreting Carcinogenicity: Summary of All Organs

    Interspecies Differences in Response to Chemical Carcinogens, David B. Clayson and Kirk T. Kitchin


    Kirk T. Kitchin (US EPA, Research Triangle Park, North Carolina, USA) (Author)