Carcinogenicity: Testing: Predicting, and Interpreting Chemical Effects, 1st Edition (Hardback) book cover


Testing: Predicting, and Interpreting Chemical Effects, 1st Edition

By Kirk T. Kitchin

CRC Press

920 pages

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Hardback: 9780824798932
pub: 1998-10-29
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Offers comprehensive coverage of currently available cancer predictors, the most recent research on carcinogenicity, and the design and interpretation of carcinogenicity experiments. Presents mouse, rat, and human carcinogenicity data for the liver, kidney, breast, cervix, prostate, hematopoietic system, colon, skin, urinary bladder, mouth, stomach, thyroid, and pancreas.

Table of Contents

Testing Carcinogenicity

The Cancer Bioassay, Paul Grasso and Shirley Price

Value, Validity, and Historical Development of Carcinogenesis Studies for Predicting and Confirming Carcinogenic Risks to Humans, James Huff

The Maximum Tolerated Dose and Secondary Mechanisms of Carcinogenesis, James S. MacDonald and Harvey E. Scribner

Mouse Liver Carcinogenesis, Thomas L. Goldsworthy, Elizabeth H. Romach, and Tony R. Fox

Information Sources on the Carcinogenicity of Chemicals, Kirk T. Kitchin

Predicting Carcinogenicity

Use of Mutagenicity for Predicting Carcinogenicity, David M. DeMarini

Improved Predictivity of Chemical Carcinogens: The Use of a Battery of SAR Models, Orest T. Macina, Ying Ping Zhang, and Herbert S. Rosenkranz

The ke Test, George Bakale

Gap Junctional Intercellular Communication as a Method to Detect and Predict Carcinogenicity, Vladimir Krutovskikh and Hiroshi Yamasaki

Predicting Chemical Carcinogenicity by In Vivo Biochemical Parameters, Kirk T. Kitchin and Janice L. Brown

Liver Pyruvate Kinase as a Predictor of Promotion of Hepatocarcinogenesis, Susumu Yanagi

Predicting Carcinogenicity: Peroxisome Proliferators, Jonathan D. Tugwood and Clifford R. Elcombe

The Rat Liver Hepatocellular-Altered, Focus-Limited Bioassay for Chemicals with Carcinogenic Activity, Gary M. Williams and Harald Enzmann

Transgenic Animals as Predictive Models for Identifying Carcinogens, William C. Eastin and Raymond W. Tennant

Interpreting Carcinogenicity: Organs with High Animal and Low Human Cancer Rates

Human Liver Carcinogenesis, Wai Nang Choy

Comparative Kidney Carcinogenesis in Laboratory Rodents and Humans, Gordon C. Hard

Forestomach and Glandular Stomach Carcinogenesis, Masao Hirose and Nobuyuki Ito

Thyroid Carcinogenesis, Geraldine Anne Thomas

Interpreting Carcinogenicity: Organs with High Animal and High Human Cancer Rates

Lung Carcinogenesis, F. F. Hahn

Mammary Cancer, Minako Nagao and Takashi Sugimura

Cancers of the Hematopoietic System in Rodents and Humans: Chemical Factors, Physical Factors, and Molecular Epidemiological Studies, Elizabeth W. Newcomb

Urinary Bladder Cancer, Shoji Fukushima, Hideki Wanibuchi, and Shinji Yamamoto

Cancers of the Oral Cavity, Dhananjaya Saranath

Reactive Intermediates and Skin Cancer, Moushumi Lahiri, Hasan Mukhtar, and Rajesh Agarwal

Interpreting Carcinogenicity: Organs with Low Animal and High Human Cancer Rates

Prostate Cancer, Maarten C. Bosland

Exocrine Pancreatic Cancer, H. B. Bueno-de-Mesquita, Marko Jan Appel, Henk J. van Kranen, and Ruud A. Woutersen

Colorectal Cancer, Gabriel A. Kune and Luis Vitetta

Cervix Uteri and Uterus Cancer, Marios Marselos

Interpreting Carcinogenicity: Summary of All Organs

Interspecies Differences in Response to Chemical Carcinogens, David B. Clayson and Kirk T. Kitchin

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Environmental Science