1st Edition

Cardiovascular Plaque Rupture

Edited By David L. Brown Copyright 2002

    Illustrating the development and determinants of possible plaque rupture, Cardiovascular Plaque Rupture provides an in-depth review of the pathology, etiology, cellular and molecular biology, diagnosis, and treatment of plaque in the cardiovascular system-exploring the roles of physical stress, inflammation, and infectious agents on the growth of cardiovascular disease.

    Characterize and identify vulnerable plaque using novel imaging modalities and modifications of existing invasive and noninvasive technologies!

    Containing recent data on preventive gene therapy and antibiotic stabilization of plaque, >Cardiovascular Plaque Rupture considers

  • serine proteinase and metalloproteinase inhibitors in the prevention of plaque rupture
  • lipid lowering to stabilize plaque
  • clinical trial designs to demonstrate therapeutic prevention of plaque rupture
  • and more!
    Discussing current methods of plaque assessment, including intravascular ultrasound and elastography, in vivo spectroscopic analysis, optical coherence tomography, thermography, and magnetic resonance imaging, Cardiovascular Plaque Rupture is an indispensable guide for cardiologists, vascular and cardiac surgeons, radiologists, vascular biologists, endocrinologists, and fellows, residents, and medical school students in these disciplines.
  • Background and Pathophysiology

    Development of the Atherosclerotic Plaque
    Joan W. Berman, Marwan Kazimi, and Harry Ma
    Clinical and Pathological Correlates
    Renu Virmani, Allen P. Burke, Andrew Farb, and Frank D. Kolodgie
    The Role of Inflammation in Plaque Rupture
    Anton E. Becker and Allard C. van der Wal
    Molecular Mechanisms of Plaque Weakening and Disruption
    Zorina S. Galis
    Epidemiological Evidence for Inflammation in Plaque Rupture
    Russell P. Tracy
    Role of Mechanical Stress in Plaque Rupture: Mechanical and Biological Interactions


    David L. Brown