1st Edition

Carotenoids and Retinal Disease

Edited By John T. Landrum, John Nolan Copyright 2010
272 Pages 44 B/W Illustrations
by CRC Press

272 Pages 44 B/W Illustrations
by CRC Press

272 Pages
by CRC Press

The macular carotenoids play key roles in eye health and retinal disease. Age-related macular degeneration (AMD), the most common cause of acquired blindness in much of the world, is associated with low levels of macular pigment. Macular pigment is also essential for enhancing visual performance by reducing glare disability and improving photostress recovery. Carotenoids and Retinal Disease... Read more

Macular Pigment: From Discovery to Function
John T. Landrum, Richard Bone, Martha Neuringer, and Yisi Cao

Risk Factors for Age-Related Macular Degeneration and Their Relationship with the Macular Carotenoids
Tos T.J.M. Berendschot

Epidemiology and Aetiopathogenesis of Age-Related Macular Degeneration
Sobha Sivaprasad and Phil Hykin

Relationships of Lutein and Zeaxanthin to Age-Related Macular Degeneration: Epidemiological Evidence
Julie A. Mares

Clinical Trials Investigating the Macular Carotenoids
Sarah Sabour-Pickett, John M. Nolan, and Stephen Beatty

The Promise of Molecular Genetics for Investigating the Influence of Macular Xanthophylls on Advanced Age-Related Macular Degeneration
John Paul SanGiovanni and Martha Neuringer

A Review of Recent Data on the Bioavailability of Lutein and Zeaxanthin
Mareike Beck and Wolfgang Schalch

Multiple Influences of Xanthophylls Within the Visual System
Billy R. Hammond and James G. Elliott

Transport and Retinal Capture of the Macular Carotenoids
Binxing Li and Paul S. Bernstein

Measurement and Interpretation of Macular Carotenoids in Human Serum
David I. Thurnham, Katherine A. Meagher, Eithne Connolly, and John M. Nolan

Xanthophyll–Membrane Interactions: Implications for Age-Related Macular Degeneration
Witold k. Subczynski, Anna Wisniewska-Becker, and Justyna Widomska

Light Distribution on the Retina: Implications for Age-Related Macular Degeneration
Richard A. Bone, Jorge C. Gibert, and Anirbaan Mukherjee

Index

Biography

John T. Landrum, PhD, is a professor in the Department of Chemistry and Biochemistry at Florida International University (FIU), where in addition to his role as a faculty member he serves as a director at the Office of Pre-Health Professions Advising for the College of Arts and Sciences. His current research efforts are focused on understanding the mechanisms of biological recognition of individual carotenoids, their absorption and transport, and their role in the developing human eye. In 2004, Professor Landrum’s contributions in the field of chemistry were recognized by the FIU with an award for Excellence in Research. He has authored or coauthored 66 articles and chapters in peer-reviewed journals and books.

John M. Nolan, Ph.D., is a Fulbright scholar, Howard and European Research Council (ERC) Fellow, adjunct professor of Trinity College Dublin, and principal investigator of the Macular Pigment Research Group (MPRG), Waterford Institute of Technology, Ireland. Professor Nolan was one of the founders of the MPRG, which leads world-class research initiatives in the role of eye nutrition for vision and prevention of blindness and which is now the largest group worldwide studying the macular carotenoids.