1st Edition

Case Reports in Cardiology Valvular Heart Disease

Edited By William C. Roberts Copyright 2024
    342 Pages 44 Color & 161 B/W Illustrations
    by CRC Press

    342 Pages 44 Color & 161 B/W Illustrations
    by CRC Press

    342 Pages 44 Color & 161 B/W Illustrations
    by CRC Press

    From the earliest days of medicine to the present, case reports have been a critical aspect of clinical education and knowledge development. In this comprehensive volume, Dr. William C. Roberts, a renowned expert in the field, explores the rich history and ongoing importance of case reports in cardiology.

    Through engaging and insightful analysis, the book demonstrates how case reports have provided physicians with crucial insights into rare diseases, complex conditions, and groundbreaking treatments. Drawing on a vast range of sources, from ancient manuscripts to cutting-edge journals, it presents a unique perspective on the role of case reports in medical education and practice of valvular heart disease and analogous cardiac morbidities including carcinoid heart disease with a rich coverage on heart valve bioprosthesis. It underscores how case reports can be used to enhance diagnostic accuracy, identify new treatment options, and promote innovation in the field. In addition, the book provides valuable insights into the process of writing and publishing case reports, including tips for young physicians looking to break into the field.

    The book will be an indispensable guide to the history, practice, and ongoing significance of case reports for medical students, physicians, and researchers alike.

    Key features-

    • Provides a rich repository of diverse case reports in cardiology published by the editor and his colleagues over 61 years
    • Features 65 clinical case studies related to Valvular Heart Disease useful for medical students and practicing cardiologists
    • Valuable resource for young physicians seeking to establish a foothold in medical research and academics

    *Note: Cases are numbered based on their number in WCR’s CV.


    8. Roberts WC, Rabson AS. Focal glomerular lesions in fungal endocarditis. Ann Intern Med. 1962;56(4):610-618.

    14. Levine RJ, Roberts WC, Morrow AG. Traumatic aortic regurgitation. Am J Cardiol. 1962;10(5):752-763.

    26. Friedman RM, Roberts WC. Myocardial embolus—a complication of mitral valvulotomy. N Engl J Med. 1965;272(5):251-252.

    32. Roberts WC, Mason DT, Wright LD Jr. The nondistensible right atrium of carcinoid disease of the heart. Am J Clin Pathol. 1965;44(6):627-631.

    35. Berard CW, Roberts WC, Kahler RL. Pulmonary arteriovenous fistula and rheumatic cardiac disease. Am Heart J. 1966;71(3):390-392.

    38. Brawley RK, Roberts WC, Morrow AG. Intestinal infarction resulting from nonobstructive mesenteric arterial insufficiency. Arch Surg. 1966;92(3):374-378.

    56. Roberts WC, Berard CW, Braunwald NS. Roentgenogram of the month. Dis Chest. 1967;51(4):439-440.

    65. Carpenter DF, Golden A, Roberts WC. Quadrivalvular rheumatoid heart disease associated with left bundle branch block. Am J Med. 1967;43(6):922-929.

    78. Roberts WC, Kehoe JA, Carpenter DF, Golden A. Cardiac valvular lesions in rheumatoid arthritis. Arch Intern Med. 1968;122(2):141-146.

    89. Glancy DL, Massumi RA, Roberts WC. Fatal acute rheumatic fever in childhood despite corticosteroid therapy. A note on the spectrum of childhood rheumatic fever. Am Heart J. 1969;77(4):534-537.

    97. Ewy GA, Lotz M, Geraghty M, Marcus FI, Roberts WC. Clinical pathologic conference. Am Heart J. 1969;78(2):259-265.

    114. Roberts WC, Levinson GE, Morrow AG. Lethal ball variance in the Starr-Edwards prosthetic mitral valve. Arch Intern Med. 1970;126(3):517-521.

    156. Shepherd RL, Glancy DL, Stinson EB, Roberts WC. Hemodynamic confirmation of obstruction to left ventricular inflow by a caged-ball prosthetic mitral valve. Case report. J Thorac Cardiovasc Surg. 1973;65(2):252-254.

    182. Roberts WC, Hollingsworth JF, Bulkley BH, Jaffe RB, Epstein SE, Stinson EB. Combined mitral and aortic regurgitation in ankylosing spondylitis. Angiographic and anatomic features. Am J Med. 1974;56(2):237-243.

    231. Hammer WJ, Hearne MJ, Roberts WC. Cocking of a poppet-disc prosthesis in the aortic position. A cause of intermittent aortic regurgitation. J Thorac Cardiovasc Surg. 1976;71(2):259-261.

    243. McReynolds RA, Ali N, Cuadra M, Roberts WC. Combined acute rheumatic fever and congenitally bicuspid aortic valve: a hitherto unconfirmed combination. Chest. 1976;70(1):98-100.

    267. Arnett EN, Kastl DG, Garvin AJ, Roberts WC. Clinical pathologic conference: a conversation on prosthetic valve endocarditis. Am Heart J. 1977;93(4):511-517.

    274. Jones AA, Otis JB, Fletcher GF, Roberts WC. A hitherto undescribed cause of prosthetic mitral valve obstruction. J Thorac Cardiovasc Surg. 1977;74(1):116-117.

    301. Breyer RH, Arnett EN, Spray TL, Roberts WC. Prosthetic-valve endocarditis due to Listeria monocytogenes. Am J Clin Pathol. 1978;69(2):186-187.

    369. Waller BF, Reis RL, McIntosh CL, Epstein SE, Roberts WC. Marfan cardiovascular disease without the Marfan syndrome. Fusiform ascending aortic aneurysm with aortic and mitral valve regurgitation. Chest. 1980;77(4):533-540.

    402. Davis WA, Isner JM, Bracey AW, Roberts WC, Garagusi VF. Disseminated Petriellidium boydii and pacemaker endocarditis. Am J Med. 1980;69(6):929-932.

    413. Ishihara T, Ferrans VJ, Jones M, Cabin HS, Roberts WC. Calcific deposits developing in a bovine pericardial bioprosthetic valve 3 days after implantation. Circulation. 1981;63(3):718-723.

    458. Borkon AM, McIntosh CL, Jones M, Roberts WC, Morrow AG. Inward stent-post bending of a porcine bioprosthesis in the mitral position: cause of bioprosthetic dysfunction. J Thorac Cardiovasc Surg. 1982;83(1):105-107.

    491. McManus BM, Katz NM, Blackbourne BD, Gottdiener JS, Wallace RB, Roberts WC. Acquired cor triatriatum (left ventricular false aneurysm): complication of active infective endocarditis of the aortic valve with ring abscess treated by valve replacement. Am Heart J. 1982;104(2 Pt 1):312-314.

    497. Waller BF, Kishel JC, Roberts WC. Severe aortic regurgitation from systemic hypertension. Chest. 1982;82(3):365-368.

    523. Roberts WC, Arnett EN, Aisner SC, Techlenberg P. Aortic valve stenosis and left ventricular apical aneurysm and/or rupture: real or potential complications of persistent left ventricular systolic hypertension after acute myocardial infarction. Am Heart J. 1983;105(3):513-514.

    531. Ferrans VJ, McManus B, Roberts WC. Cholesteryl ester crystals in a porcine aortic valvular bioprosthesis implanted for eight years. Chest. 1983;83(4):698-701. v

    543. Silver MA, Oranburg PR, Roberts WC. Severe mitral regurgitation immediately after mitral valve replacement with a parietal pericardial bovine bioprosthesis. Am J Cardiol. 1983;52(1):218-219.

    633. Lester WM, Roberts WC. Fatal bioprosthetic regurgitation immediately after mitral and tricuspid valve replacements with Ionescu-Shiley bioprostheses. Am J Cardiol. 1985;55(5):590-592.

    724. Barbour DJ, McIntosh CL, Roberts WC. Extensive calcification of a bioprosthesis in the tricuspid valve position and minimal calcification of a simultaneously implanted bioprosthesis in the mitral valve position. Am J Cardiol. 1987;59(1):179-180.

    788. Potkin BN, McIntosh CL, Cannon RO III, Roberts WC. Bioprostheses in tricuspid and mitral valve positions for 100 months with heavier calcific deposits on the left-sided valve followed by new bioprostheses in both positions for 95 months with heavier calcific deposits on the right-sided valve. Am J Cardiol. 1988;61(11):947-949.

    806. Mann JM, Roberts WC. "Quadricuspidization" of a previously three-cuspid aortic valve. Am Heart J. 1988;116(3):889-890.

    811. Kalan JM, McIntosh CL, Bonow RO, Roberts WC. Development of severe stenosis in a previously purely regurgitant, congenitally bicuspid aortic valve. Am J Cardiol. 1988;62(13):988-989.

    840. Dollar AL, Pierre-Louis ML, McIntosh CL, Roberts WC. Extensive multifocal myocardial infarcts from cloth emboli after replacement of mitral and aortic valves with cloth-covered, caged-ball prostheses. Am J Cardiol. 1989;64(5):410-412.

    876. Roberts CS, Roberts WC. Huge, unattached left atrial thrombus in mitral stenosis. Clin Cardiol. 1990;13(4):295-297.

    898. Kragel AH, Lapa JA, Roberts WC. Cardiovascular findings in alkaptonuric ochronosis. Am Heart J. 1990;120(6 Pt 1):1460-1463.

    903. Roberts WC, Dollar AL. Extreme obstruction to left ventricular outflow by a bioprosthesis in the mitral valve position. Am Heart J. 1991;121(2 Pt 1):607-608.

    919. Klues HG, Statler LS, Wallace RB, Roberts WC. Massive calcification of a porcine bioprosthesis in the aortic valve position and the role of calcium supplements. Am Heart J. 1991;121(6 Pt 1):1829-1831.

    1167. Lander SR, Taylor JE, Roberts WC. Congenitally bicuspid stenotic aortic valves in octogenarians. Am J Geriatr Cardiol. 1999;8(6):304-306.

    1306. Grayburn PA, Hamman BL, Roberts WC. Severe late (16 years) dysfunction of a bioprosthesis in the mitral valve position without dysfunction of a bioprosthesis in the aortic valve position. Proc Bayl Univ Med Cent. 2004;17(2):214.

    1335. Farooq H, Grayburn P, Roberts WC. Severe regurgitation immediately after replacement of a dysfunctional bioprosthesis in the mitral valve position. Am J Cardiol. 2005;95(5):703-704.

    1357. Theleman KP, Grayburn PA, Roberts WC. Mitral "annular" calcium forming a complete circle "O" causing mitral stenosis in association with a stenotic congenitally bicuspid aortic valve and severe coronary artery disease. Am J Geriatr Cardiol. 2006;15(1):58-61.

    1359. Sims JB, Roberts BJ, Roberts WC, Hebeler RF Jr, Grayburn PA. The heaviest known operatively-excised aortic valve. Am J Cardiol. 2006;97(4):588-589.

    1361. Peterman MA, Donsky MS, Matter GJ, Roberts WC. A Starr-Edwards model 6120 mechanical prosthesis in the mitral valve position for 38 years. Am J Cardiol. 2006;97(5):756-758.

    1374. Roberts WC, Grayburn PA. Sudden onset of "cardiac" symptoms, (?) mild or severe aortic valve stenosis involving a congenitally bicuspid aortic valve, and nearly normal coronary arteries in an octogenarian. Am J Geriatr Cardiol. 2006;15(3):185-187.

    1390. Roberts WC, Ko JM, Matter GJ. Isolated aortic valve replacement without coronary bypass for aortic valve stenosis involving a congenitally bicuspid aortic valve in a nonagenarian. Am J Geriatr Cardiol. 2006;15(6):389-391.

    1423. Roberts WC, Ko JM, Schussler JM. Sudden collapse in aortic stenosis. Am J Geriatr Cardiol. 2007;16(5):319-320.

    1445. Gibbs WN, Hamman BL, Roberts WC, Schussler JM. Diagnosis of congenital unicuspid aortic valve by 64-slice cardiac computed tomography. Proc Bayl Univ Med Cent. 2008;21(2):139.

    1502. Roberts WC, Velasco CE, Ko JM, Matter GJ. Comparison of the quantity of calcific deposits in bovine pericardial bioprostheses in the mitral and aortic valve positions in the same patient late after double-valve replacement. J Thorac Cardiovasc Surg. 2009;138(6):1448-1450.

    1506. Roberts WC, Ko JM, Schumacher JR, Henry AC III. Combined mitral and aortic stenosis of rheumatic origin with double-valve replacement in an octogenarian. Int J Cardiol. 2010;140(1):e1-e3.

    1531. Roberts WC, Varughese CA, Ko JM, Grayburn PA, Hebeler RF Jr, Burton EC. Carcinoid heart disease without the carcinoid syndrome but with quadrivalvular regurgitation and unsuccessful operative intervention. Am J Cardiol. 2011;107(5):788-792.

    1559. Head SJ, Ko J, Singh R, Roberts WC, Mack MJ. 43.3-year durability of a Smeloff-Cutter ball-caged mitral valve. Ann Thorac Surg. 2011;91(2):606-608.

    1589. Roberts WC, Zafar S, Ko JM, Carry MM, Hebeler RF. Combined congenitally bicuspid aortic valve and mitral valve prolapse causing pure regurgitation. Proc Bayl Univ Med Cent. 2013;26(1):30-32.

    1611. Sarmast S, Schussler JM, Ko JM, Roberts WC. Infective endocarditis superimposed on a massively calcified severely stenotic congenitally bicuspid aortic valve. Proc Bayl Univ Med Cent. 2014;27(1):37-38.

    1636. Roberts CC, Parmar RJ, Grayburn PA, Patankar GR, Ko JM, Hamman BL, Roberts WC. Clues to diagnosing carcinoid heart disease as the cause of isolated right-sided heart failure. Am J Cardiol. 2014;114(10):1623-1626.

    1723. Fathima S, Hall SA, Grayburn PA, Roberts WC. The mitral valve 16-months after operative insertion of the Alfieri stitch. Am J Cardiol. 2019;123(4):695-696.

    1727. Thakkar SJ, Grayburn PA, Hall SA, Roberts WC. Orthotopic heart transplantation for ankylosing spondylitis masquerading as nonischemic cardiomyopathy. Am J Cardiol. 2019;123(10):1732-1735.

    1729. Roberts WC, Grayburn PA, Lander SR, Meyer DM, Hall SA. Effect of progressive left ventricular dilatation on degree of mitral regurgitation secondary to mitral valve prolapse. Am J Cardiol. 2019;123(11):1887-1888.

    1733. Roberts WC, Lee AY, Lander SR, Roberts CS, Hamman BL. Libman-Sacks endocarditis involving a bioprosthesis in the aortic valve position in systemic lupus erythematosus. Am J Cardiol. 2019;124(2):316-318.

    1735. Chalkley RA, Kim CW, Choi JW, Roberts WC, Schussler JM. Smeloff-Cutter mechanical prosthesis in the aortic position for 49 years. Am J Cardiol. 2019;124(3):457-459.

    1740. Roberts WC, Siddiquiz S, Rafael-Yarihuaman AE, Roberts CS. Management of adults with normally functioning congenitally bicuspid aortic valves and dilated ascending aortas. Am J Cardiol. 2020;125(1):157-160.

    1753. Ather N, Roberts WC. Cardiovascular ochronosis. Cardiovasc Pathol. 2020;48:107219.

    1760. Roberts WC, Kapoor D, Main ML. Virtually all complications of active infective endocarditis occurring in a single patient. Am J Cardiol. 2020;137:127-129.

    1763. Sovic WR, Ngo Q, Patlolla S, Guileyardo JM, Roberts WC. Isolated mitral valve endocarditis with ring abscess and pericarditis in end-stage renal disease. Proc Bayl Univ Med Cent. 2021; 34: 403-404.

    1780. Makhdumi M, Meyer DM, Roberts WC. Malignancy-associated non-bacterial thrombotic endocarditis causing aortic regurgitation and leading to aortic valve replacement. Am J Cardiol. 2021;154:120-122.


    William C. Roberts, MD, was born in Atlanta, Georgia, on September 11, 1932. He graduated from Southern Methodist University and Emory University School of Medicine. He did his training in internal medicine at the Boston City Hospital and at The Johns Hopkins Hospital, and his training in pathology at the National Institutes of Health. From July 1964 to March 1993, he was Chief of Pathology at the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. He has published more than 1,700 articles, authored or edited 31 books, and lectured in over 2,200 cities worldwide. He has contributed information on many cardiovascular conditions. During the past 44 years, Dr. Roberts has been program director for the Williamsburg Conference on Heart Disease held every December in Williamsburg, Virginia. The American College of Cardiology Foundation has sponsored this conference for 30 years. Since March 1993, Dr Roberts had been the executive director of the Baylor Heart and Vascular Institute at Baylor University Medical Center in Dallas, Texas. He was also the editor-in-chief of the Baylor University Medical Center Proceedings and Dean of the A. Webb Roberts Center for Continuing Medical Education at Baylor Scott & White Health. He had been the editor-in-chief of The American Journal of Cardiology since June 1982. He received many honors including the 1978 Gifted Teacher Award from The American College of Cardiology; the 1983 College Medalist Award of the American College of Chest Physicians; the Public Health Service Commendation Medal in 1979; the 1984 Richard and Hilda Rosenthal Foundation Award from the Council of Cardiology of the American Heart Association; an honorary Doctor of Science degree from Far Eastern University, Manila, Philippines in 1995; the designation of Master from The American College of Cardiology in 2004, and the Lifetime Achievement Award of The American College of Cardiology in 2016; and the Lifetime Achievement Award for D’s CEO’s Excellence in Healthcare Awards in 2021.

    Sadly, Dr. William C. Roberts passed away in June 2023 at the age of 90, just as this book series went into production.