1st Edition

Causal Inference in Pharmaceutical Statistics

By Yixin Fang Copyright 2024
246 Pages 28 B/W Illustrations
by Chapman & Hall

246 Pages 28 B/W Illustrations
by Chapman & Hall

Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with... Read more

Preface

1. Introduction

2. Randomized Controlled Clinical Trials

3. Missing Data Handling

4. Intercurrent Events Handling

5. Longitudinal Studies

6. Real-World Evidence Studies

7. The Art of Estimation (I): M-estimation

8. The Art of Estimation (II): TMLE

9. The Art of Estimation (III): LTMLE

10. Sensitivity Analysis

11. A Roadmap for Causal Inference

12. Applications of the Roadmap

Bibliography

Index

Biography

Yixin Fang, Ph.D. is Director of Statistics and Research Fellow at AbbVie Inc. He obtained his Ph.D. in Statistics from Columbia University and is an experienced statistician and data scientist who has a history of working in both the biopharmaceutical industry and academia.

"This book can serve as a reference for experienced statisticians interested in extending their research to semiparametric efficiency theory and incorporating machine learning approaches into their causal methodology, as well as an introductory resource for graduate students in statistics, bio-statistics, or data science interested in causal inference and applications to pharmacy."

-Ashley L. Buchanan in theĀ Journal of the American Statistical Association, July 2025.