Cell Culture Technology for Pharmaceutical and Cell-Based Therapies: 1st Edition (Hardback) book cover

Cell Culture Technology for Pharmaceutical and Cell-Based Therapies

1st Edition

Edited by Sadettin Ozturk, Wei-Shou Hu

CRC Press

776 pages | 23 Color Illus. | 102 B/W Illus.

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Hardback: 9780824753344
pub: 2005-08-30
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pub: 2005-08-30
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Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology development in the production of biotechnology products, tissue engineering, and cell-based therapies. Offering detailed guidance, they cover the steps leading up to the creation of viable therapies including host cell selection, cloning and gene amplification, bioreactor design and operation, protein purification, optimization, scale-up, and facility design.


"…The editors have brought together an outstanding group of experts from both private industry and academia….recommend[ed]."

-Doody's Reviews

Table of Contents

Preface. Cell Culture Technology: An Overview. Recombinant DNA Technology and Cell Line Development. Medium Development. Cell Metabolism. Protein Glycosylation. Cell Culture Bioreactors. Aeration, Mixing and Hydrodynamics in Bioreactors. Instrumentation and Process Control. Cell Culture Kinetics and Modeling. Fed-Batch Cultivation Of Mammalian Cells For Production Of Recombinant Proteins. Optimization of High Density Perfusion Bioreactors. Cell Separation And Product Capture. Downstream Processing. Formulation, Finishing, and Packaging. Validation Of Cell Culture Based Processes & Qualification Of Associated Equipment And Facility. Facility Design. Transient Expression of Proteins. Large-Scale Propagation of Insect Cells. Advances In Adult Stem Cell Culture. Ex Vivo Culture Of Hematopoietic And Mesenchymal Stem Cells For Tissue Engineering And Cell-Based Therapies.

About the Series

Biotechnology and Bioprocessing

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Pharmacology
SCIENCE / Biotechnology