Cell Surface Carbohydrates and Cell Development summarizes knowledge on the structure and function of cell surface carbohydrates in development and differentiation. The chapters include reviews on the expression of cell type-specific carbohydrates and their roles in cell-cell interaction. In particular, the role of cell surface carbohydrates in immune cell response, malignant transformation, fertilization, and neural cell development are addressed. This includes the exciting discovery about the role of adhesive molecules in leukocyte-endothellium interaction.
Cell Surface Carbohydrates and Cell Development also summarizes the latest knowledge on structure and biosynthesis of carbohydrates, the role of specific carbohydrate modification, and animal lectins. The book will be useful to researchers and students interested in the biology of glycoproteins and biotechnology.
Structure and Biosynthesis of Cell Surface Carbohydrates (Drs. Akira Kobata and Seiichi Takasaki). Role of Oligosaccharides in the Intracellular and Intracellular Trafficking of Mammalian Glycoproteins (Dr. Ajit Varki). LEC-CAMs (Selectins): Lectin-Like Receptors Involved in Leukocyte Recruitment (Dr. Lloyd Stoolman). Animal Lectin: Possible Role in Development (Dr. Richard D. Cummings). Cell Surface Carbohydrates in Hematopoietic Cell Differentiation and Malignancy (Dr. Minoru Fukuda). Changes in Glycosylation Associated with Malignant Transformation and Tumor Progression (Dr. James W. Dennis). Glycoconjugates in the Development of the Nervous System (Drs. Miyuki Yamamoto and Gerald A. Schwarting). Cell Surface Carbohydrates and Mammalian Fertilization (Dr. Paul Wassarman). Early Embryogenesis (Dr. Takashi Muramatsu). Proteoglycans in Development (Dr. Daniel D. Carson). Developmental Glycobiology of Dictyostelium discoideum (Dr. Hudson H. Freeze).