Explores a Range of Multiscale Biomechanics/Mechanobiology Concepts
Cell and Matrix Mechanicspresents cutting-edge research at the molecular, cellular, and tissue levels in the field of cell mechanics. This book involves key experts in the field, and covers crucial areas of cell and tissue mechanics, with an emphasis on the roles of mechanical forces in cell–matrix interactions. Providing material in each chapter that builds on the previous chapters, it effectively integrates length scales and contains, for each length scale, key experimental observations and corresponding quantitative theoretical models.
Summarizes the Three Hierarchical Levels of Cell Mechanics
The book contains 14 chapters and is organized into three sections. The first section focuses on the molecular level, the second section details mechanics at the cellular level, and the third section explores cellular mechanics at the tissue level. The authors offer a thorough description of the roles of mechanical forces in cell and tissue biology, and include specific examples. They incorporate descriptions of associated theoretical models, and provide the data and modeling framework needed for a multi-scale analysis. In addition, they highlight the pioneering studies in cell–matrix mechanics by Albert K. Harris.
The topics covered include:
Cell and Matrix Mechanics succinctly and systematically explains the roles of mechanical forces in cell–matrix biology. Practitioners and researchers in engineering and physics, as well as graduate students in biomedical engineering and mechanical engineering related to mechanobiology, can benefit from this work.
Active Mechanics of the Cytoskeleton; José Alvarado and Gijsje Koenderink
Mechanobiology of the Cell Membrane;Peter J Butler, Hari S Muddana, and Sara Farag
Cellular Reconstitution of Actively Self-Organizing Systems;Orit Siton-Mendelson, Barak Gilboa, Yaron Ideses, and Anne Bernheim-Groswasser
Structural and Dynamical Hierarchy of Fibrillar Collagen;Xiaojing Teng and Dr Wonmuk Hwang
Cell–Matrix and Cell–Cell Mechanical Interactions;Assaf Zemel and Ralf Kemkemer
Dynamic Stress Fiber Reorganization on Stretched Matrices;Roland Kaunas
Mechanics of Cell-Seeded ECM Scaffolds;Guy M Genin and Elliot L Elson
Cell Motility in 3D Matrices;Yasha Sharma and Muhammad H Zaman
Collective Cell Migration;Nir S Gov
Connective Tissue Development;Albert K. Harris
Cellular Forces in Morphogenesis;Larry A Taber
Mechanics of Tissue Morphogenesis;Michael J Siedlik and Celeste M Nelson
Continuum Physics of Tumor Growth;Kristen L Mills, Shiva Rudraraju, Ralf Kemkemer, and Krishna Garikipati
Cell Force–Mediated Collagen Remodeling in Cancer Metastasis;Paolo P Provenzano