With chapter contributions from more than 30 metal biology experts, Cellular and Molecular Biology of Metals explains the role of key divalent metal ions involved in the molecular and cellular biology of various target cell populations. Although it primarily focuses on homeostatic metals, such as nickel, zinc, and chromium, the text also discusses a few environmentally pertinent, toxic divalent cations, including mercury, cadmium, and arsenic.
This authoritative resource reviews the physiological mechanisms underlying the handling of essential and toxic metal ions, including metal ion homeostasis, metals and enzyme activity, metals and transcriptional regulation, and metal ion transport. It also analyzes other functions designed to avoid metal-induced toxicity and mediate the metal enhancement of cellular function.
The role of metal ions and their effect on mammalian cells and organs are only beginning to be truly defined. Cellular and Molecular Biology of Metals arms metals toxicologists and cellular and molecular biologists with the necessary knowledge they need to take the research effort to the next level.
Key selling features:
- Presents the most recent advances in the cell and molecular biology of metal ions
- Provides a complete exploration of transport mechanisms
- Addresses homeostatic metals as well as several environmentally relevant toxic divalent cations
- Features contributions from experts in their respective fields
Table of Contents
Cellular Inorganic Chemistry Concepts and Examples
David H. Petering, Rajendra Kothinti, Jeffrey Meeusen, and Ujala Rana
Molecular and Cellular Biology of Mercury in the Kidneys
Rudolfs K. Zalups and Christy C. Bridges
Essential and Toxic Metal Transport in the Liver
Nazzareno Ballatori, David A. Aremu, and Michael S. Madejczyk
Molecular and Cell Biology of Lead
Bruce A. Fowler
Transport and Biological Impact of Manganese
Keith M. Erikson, Khristy J. Thompson, and Michael Aschner
Metallothionein and Metal Homeostasis
Cellular and Molecular Biology of Iron-Binding Proteins
Danuta S. Kalinowski and Des R. Richardson
The Regulatory and Signaling Functions of Zinc Ions in Human Cellular Physiology Hajo Haase and Wolfgang Maret
Glutathione, Protein Thiols, and Metal Homeostasis
Lawrence H. Lash
Ionic and Molecular Mimicry and the Transport of Metals
Christy C. Bridges and Rudolfs K. Zalups
Heavy Metal Transport and Detoxification in Crustacean Gastrointestinal and Renal Epithelial Cells
Gregory A. Ahearn
Metals and Cell Adhesion Molecules
Alan R. Parrish and Walter C. Prozialeck
Iron Metabolism and Disease
Giada Sebastiani and Kostas Pantopoulos
Metal Influences on Immune Function
Michael A. Lynes, Kathryn Pietrosimone, Gregory Marusov,Douglas V. Donaldson, Clare Melchiorre, Xiuyun Yin, David A. Lawrence, and Michael J. McCabe
Rudolfs K. Zalups, PhD, trained as a fellow and instructor at the Mayo Clinic, Yale University School of Medicine, University of Maryland School of Medicine, and the University of Rochester School of Medicine and Dentistry. He is now a professor at the Mercer University School of Medicine in Macon, Georgia.
James Koropatnick, PhD, is a Distinguished Oncology Scientist, Director of the LRCP Cancer Research Laboratory Program, Director of the UWO/CIHR Strategic Training Program in Cancer Research and Technology Transfer, Assistant Director of the Lawson Health Research Institute, and a Full Professor in the UWO Department of Oncology with cross-appointments in the UWO Departments of Microbiology and Immunology, Physiology and Pharmacology, and Pathology. He is also the Chief Scientific Officer of Sarissa, Inc. (a biotech discovery company) and sits on the Advisory Boards of Critical Outcomes Therapeutics, Inc., ID Laboratories, Inc., and MedVax Pharma, Inc.