Cellular and Molecular Mechanisms in Alzheimer’s Disease Therapeutics Vol. 2: Molecular Mechanisms

Preface

1. Investigating the Role of Amyloid Beta and Tau Peptides in Alzheimer’s Histopathological Brain Lesions

Asha Raghav, Ekta, Mohit Agrawal, Meenakshi Attri, Harpreet Singh, Arun Kumar Mishra, and Hema Chaudhary

2. Advances in Comprehending Cholinergic System and Emerging Tools to Novel Therapeutics

Mohammed Nazish Quasmi and Ashok Jangra

3. Current Progress in Mono Amino Oxidase Inhibitors in Anti-Alzheimer’s Therapy: An Understanding into Therapeutic Prospects of Inhibitors

Reena Gupta, Jitendra Gupta, and Ittishree

4. Assimilation of Transgenic Modeling Methods of Alzheimer’s Disease: Mechanism of Neurodegeneration

Junaid Tantray, Akhilesh Patel, Sanjay Nagdev, Devendra Singh Lodhi, Pradeep Golani, and Shashi Alok

5. Methods for Tailoring Medicines for Alzheimer’s Disease Treatment: Customizing Therapies According to Individual Genetic and Molecular Characteristics

P. Veeresh Babu and M. Sri Ramachandra

6. Ethical Considerations in Field of Alzheimer’s Research and Overcoming Obstacles in Clinical Trials and Ethical of Research

Yashraj Yadav, Pawan Kumar Dubey, Dishant Gupta, Jaya Sharma, Deepak Kumar Gupta, and Abhishek Agarwal

7. International Efforts in Alzheimer’s Research and Treatment: A Worldwide Outlook on Alzheimer’s Disease

Richa Gupta, Udit Chaube, Lalit Pratap Chandrvanshi, Shruti Poriya, Sanjay Khattri, and Rajendra K. Shukla

8. Role of Neurotrophins in Alzheimer’s Disease Pathogenesis to Develop Novel Therapeutics

Pranay Wal, Himangi Vig, Biswajit Dash, Ankur Agrawal, L. Karpagavalli, Kangkan Jyoti Saud, and Lakhyajit Borah

9. Behavioral Intervention and Cognitive Training in Disease Management in Alzheimer’s Disease

Shahbaz Khan, Diksha, Rajib Singh, Arshi, Brij Raj Singh, and Alka Lohani

10. Therapeutic Potential of NMDA Receptors in Alzheimer’s Disease

Virendra Kushwaha, Shriram Sisodia, Mohd. Asad Farooqi, and Kantrol Kumar Sahu

11. Unrevealing the Insights of NMDA Receptors in Neurodegenerative Disorders

Anup Kumar Chakraborty, Prashant Tiwari, Sunil Kumar Kadiri, and Deenanath Jahde

12. Pharmacological Modulation of Neurodegenerative Disorders: Therapeutic Potential and Persisting Obstacles

Radha Goel, Rosaline Mishra, Niharika, Nitin Kumar, Praveen Kumar Gaur, Mohd. Yaasir, and Ramzarahat Hashmi

Index

Biography

Prashant Tiwari, PhD, is an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He has over a decade of experience in the field of teaching and research related to pharmacology. His expertise includes drug screening, method validation for brain-targeted drug delivery, drug-induced dyskinesia revalidation, and the neuroprotective effects of benzimidazole derivatives. His research has explored the dopaminergic pathway, prolactin inhibition, and neuroprotection, with notable studies on nanoemulsions containing Lepidium sativum oil for Parkinson’s disease and Muntingia calabura leaf extract for Alzheimer’s disease. For his outstanding work, Dr. Tiwari received the Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences (2022). In addition to his research, Dr. Tiwari has authored five books, edited five books, and co-authored six book chapters. He has filed seven patents, two of which have been granted. He organized a national e-seminar on targeted drug delivery against neurodegenerative diseases, sponsored by the Department of Biotechnology (DBT), Government of India. Dr. Tiwari has been honored with various awards as well. He supervises five PhD students and has guided nine MPharm students. He is also an active member of professional bodies and serves as a peer reviewer for international journals. His research interests span neurodegenerative disorders, drug interactions, pharmacokinetics/pharmacodynamics, and metabolic disorders. He holds a PhD from Siksha O Anusandhan University, Bhubaneswar, and was a fellow of the Indian Council of Medical Research (ICMR), New Delhi, India.

Sunil Kumar Kadiri, PhD, is currently working as a Professor in the College of Pharmaceutical Sciences at Dayananda Sagar University, Bengaluru, Karnataka, India. He has 16 years of experience in teaching. His area of interest is neuropharmacology and drug interactions. He has over 50 research and review publications to his credit as well as four books and three patents. He is a professional member of the Association of Pharmaceutical Teachers of India. Dr. Kadiri completed his PhD in Pharmaceutical Sciences at JNTU Hyderabad, Telangana, India.

Kunjbihari Sulakhiya, PhD, is working as an Assistant Professor at the Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India. He has published over 20 research papers, seven review articles, and more than 10 book chapters. He has received 13 awards and fellowships, including six travel awards to present his research papers at international conferences in the USA, Canada, Japan, France, and Macau. He is a member of various professional societies, including the Indian Academy of Neurosciences, the International Society for Neurochemistry, Asia Pacific Society for Neurochemistry, Association of Pharmaceutical Teachers of India, etc. He is serving as an editorial member and reviewer for various reputed journals. His area of research is pre-clinical research in the field of neuropharmacology. He earned his MPharm and PhD in Pharmacology and Toxicology at the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India.