Cellular and Molecular Mechanisms in Alzheimer”s Disease Therapeutics Volume 1: Cellular Mechanisms

Preface

1. Exploring the Cellular and Molecular Mechanisms, Pathogenesis, Etiology, and Complications of Alzheimer’s Disease

Sandeep Hurpade, Sharad Tayade, Prashant Nikumbh, Devendra Singh Lodhi, Pradeep Golani, and Sanjay Nagdev

2. Epigenetic Alterations in Alzheimer’s Disease: DNA Methylation and Histone Modifications with Non-Coding DNA Involvement

Komal Bhati, Rahul Kaushik, Praveen Kumar Gaur, Kanak Lata, and Puja Sinoriya

3. Neuroinflammation and Role of Peripheral Immune Cells in Alzheimer’s Disease

Shweta Shrivastava, Santosh Kumar Singh, and Manish Kumar Jeengar

4. Blood-Brain Barrier Dysfunction: Relevance to Alzheimer’s Disease Pathology and Challenges and Opportunities in Drug Discovery

Sandeep Prasad Tiwari and Dipti Pal

5. Interdisciplinary Methods: The Integration of Neurology, Genetics, and Systems Biology Approaches to Comprehend Alzheimer’s Disease

Phool Chandra, Himanshu Sharma, and Neetu Sachan

6. Personalized Medicine Approaches Based on Genetic Profiling in the Treatment of Alzheimer’s Disease

Sakshi Soni, Parveen Rawat, Vandana Soni, and Sushil K. Kashaw

7. Integration of Biomarker Data into Clinical Trials and Personalized Treatment Plans

Ahana Hazra, Rideb Chakraborty, Naureen Afrose, Pratibha Bhowmick, Chowdhury Mobaswar Hossain, and Mithun Bhowmick

8. Role of Oxidative Stress and Mitochondrial Dysfunction in Progression of Alzheimer’s Disease and Its Emerging Phyto-Therapeutic and Nanomedicinal Interventions

Snigdha Bhardwaj, Radha Goel, Rosaline Mishra, and Mohd Yasir

9. MicroRNAs in the Management of Alzheimer’s Disease: Significant Approaches as Diagnostic Biomarkers

Avijit Bej, Nandita Mandal, Anwesha Das, and Arijit Nandi

10. Cellular Symphony: Harmonizing Therapeutic Approaches for Alzheimer’s Disease Through Targeted Intervention Strategies

Shubhrat Maheshwari, Anas Islam, Purba Mandal, Aditya Singh, Asad Ahmad, Mohammad Irfan, Badruddeen, Mohammad Ahmad, and Juber Akhtar

11. Exploring the Role of the Gene Mutation in the Management of Alzheimer’s Disease

Varsha Yadav, Sinchan Das, and Arjun Patra

Index

Biography

Prashant Tiwari, PhD, is an Associate Professor in the Department of Pharmacology at the College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, India. He has over a decade of experience in the field of teaching and research related to pharmacology. His expertise includes drug screening, method validation for brain-targeted drug delivery, drug-induced dyskinesia revalidation, and the neuroprotective effects of benzimidazole derivatives. His research has explored the dopaminergic pathway, prolactin inhibition, and neuroprotection, with notable studies on nanoemulsions containing Lepidium sativum oil for Parkinson’s disease and Muntingia calabura leaf extract for Alzheimer’s disease. For his outstanding work, Dr. Tiwari received the Dr. P. D. Patil National Award for Best Thesis in Pharmaceutical Sciences (2022). In addition to his research, Dr. Tiwari has authored five books, edited five books, and co-authored six book chapters. He has filed seven patents, two of which have been granted. He organized a national e-seminar on targeted drug delivery against neurodegenerative diseases, sponsored by the Department of Biotechnology (DBT), Government of India. Dr. Tiwari has been honored with various awards as well. He supervises five PhD students and has guided nine MPharm students. He is also an active member of professional bodies and serves as a peer reviewer for international journals. His research interests span neurodegenerative disorders, drug interactions, pharmacokinetics/pharmacodynamics, and metabolic disorders. He holds a PhD from Siksha O Anusandhan University, Bhubaneswar, and was a fellow of the Indian Council of Medical Research (ICMR), New Delhi, India.

Sunil Kumar Kadiri, PhD, is currently working as a Professor in the College of Pharmaceutical Sciences at Dayananda Sagar University, Bengaluru, Karnataka, India. He has 16 years of experience in teaching. His area of interest is neuropharmacology and drug interactions. He has over 50 research and review publications to his credit as well as four books and three patents. He is a professional member of the Association of Pharmaceutical Teachers of India. Dr. Kadiri completed his PhD in Pharmaceutical Sciences at JNTU Hyderabad, Telangana, India.

Kunjbihari Sulakhiya, PhD, is working as an Assistant Professor at the Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India. He has published over 20 research papers, seven review articles, and more than 10 book chapters. He has received 13 awards and fellowships, including six travel awards to present his research papers at international conferences in the USA, Canada, Japan, France, and Macau. He is a member of various professional societies, including the Indian Academy of Neurosciences, the International Society for Neurochemistry, Asia Pacific Society for Neurochemistry, Association of Pharmaceutical Teachers of India, etc. He is serving as an editorial member and reviewer for various reputed journals. His area of research is pre-clinical research in the field of neuropharmacology. He earned his MPharm and PhD in Pharmacology and Toxicology at the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India.