Chemistry and Biochemistry of Flavoenzymes summarizes the present knowledge of the chemical and physical properties of free flavin, modified flavins occurring in nature, and deazaflavin. This information forms the fundamental basis for understanding the catalytic properties of flavoenzymes. Flavoproteins involved in transport, electron transfer, oxidation, dehydrogenation and hydroxylation reactions are discussed with respect to their biochemical and biophysical properties. The book presents the catalytic mechanisms of the flavoproteins in detail and, where available, three-dimensional structures and molecular biology data are included. The medical aspects of free and protein-bound flavin are also briefly discussed. Chemistry and Biochemistry of Flavoenzymes is an essential reference source for chemists, biochemists, toxicologists, biologists, pharmacologists, and researchers in the pharmaceutical industry.
Table of Contents
1. Pyridoxine-5-P Oxidase 2. Xanthine Oxidase, Xanthine Dehydrogenase and Aldehyde Oxidase 3. D- and L-Amino Acid Oxidases 4. Methanol Oxidase 5. Lipoamide Dehydrogenase, Glutathione Reductase, Thioredoxin Reductase and Mercuric Ion Reductase - Family of Flavoenzyme Transhydrogenases 6. Refined Three-Dimensional Structure of Glutathione Reductase 7. Structure and Function of Succinate Dehydrogenase and Fumarate Reductase 8. Three-Dimensional Structure of Medium-Chain Acyl-CoA Dehydrogenase 9. Glutamate Synthase 10. Assimilatory Nitrate Reductase 11. Biological Reduction and Formation of Sulfate; The Role of APS Reductase, an Iron-Sulfur- Containing Protein 12. The Stereochemistry of the Prosthetic Groups of Flavoproteins 13. Structure and Mechanism of Spinach Glycolate Oxidase 14. General Properties of Flavodoxins 15. Structure and Redox Properties of Clostridial Flavodoxin 16. Biochemistry and Molecular Biology of Bacterial Bioluminescence 17. Acetolactate Synthase 18. Phthalate Dioxygenase Reductase and Related Flavin-Iron-Sulfur-Containing Electron Transferases 19. Nuclear Magnetic Resonance Studies on Flavoproteins 20. Acyl-Coenzyme A Dehydrogenases