1st Edition

Chemistry and Biology of Heterocycles: Two Volume Set

896 Pages 184 Color & 532 B/W Illustrations
by CRC Press

Chemistry and Biology of Heterocycles Volume 1 The exceptional capability of  N -heterocyclic scaffolds to function as biomimetics and active pharmacophores has resulted in modulating their structure, reactivity and formulation for effective drugs. The direct and viable synthetic strategies of these molecules are valuable features. Numerous methods revealed the general synthesis and... Read more

Chemistry and Biology of Heterocycles Volume 1

List of Contributors

Editor Bios

Synthesis and Biological Activity N-Heterocyclic Compounds:

β-Lactams:

Chapter 1: Synthesis of Thienamycin and Carbapenem Antibiotics

Aarif Latif Shaikh, Nutan Darandale, Dinesh Nanaji Sawant and Bimal Krishna Banik

Chapter 2: Drug Delivery of β-Lactam Antibiotics

Shibani Basu, Devalina Ray and Bimal Krishna Banik

Chapter 3: Innovative β-Lactam-Heterocyclic Metal Conjugates: Bridging Organic and Inorganic Chemistry for Enhanced Biological Activity

Antara Roy, Rajesh Nandi, Anindya S. Manna, Prakash K. Mandal, Aparna De, Niloy Karchaudhuri, and Dilip K. Maiti

Chapter 4: Computational Methods to Explore Medicinal Activity of Beta-Lactams

Aparna Das and Bimal Krishna Banik

Chapter 5: In-silico Approach towards Multidrug Resistant (MDR) β-Lactam Antibiotics and Their Metal Complex

Milan Hait, Tomeshwar Prasad, Nand Kumar Kashyap, Gourisankar Roymahapatra and Chittaranjan Sinha

Five-Membered N-Heterocyclic Compounds:

Chapter 6: Pyrroles: Synthesis and Biological Activities

Monika Kamboj, Sangeeta Bajpai, Shashikant Tiwari and Shreya Dwivedi

Chapter 7: Chemistry and Antimicrobial Activity of Triazoles and Imidazoles

Shikha Sharma, Devalina Ray and Bimal Krishna Banik

Chapter 8: Synthesis, Structure Activity Relationship Study and Biological Evaluation of Imidazole Scaffold

Biswa Mohan Sahoo, Bimal Krishna Banik, Shikha Sharma and Devalina Ray

Chapter 9: Photochromism of Arylazoimidazoles in Different Environments

Debashis Mallick* and Chittaranjan Sinha

Chapter 10: Synthesis and Biological Evaluation of Pharmaceutically Active Tetrazoles

Suman Majee, Km. Anjali, Ruchika Ruchika, Bimal K. Banik, Devalina Ray

Chapter 11: Indole and its Analogues: Unlocking New Horizons in Drug Development

Anjali Saxena, Ritwika Chowdhury and Biswajit Saha

Chapter 12: Cutting-Edge Approaches in Pyrrole/Pyrazole/Imidazole Heterocyclic Frameworks for Targeting Antibacterial and Anticancer Agents

Ankita Garg, Pawan deep Kaur Sani, Raaina Pasricha and Aman Bhalla

Chapter 13: Chemistry and Biological Application of Indoles

M. Amin Mir, Noushi Zaidi, K. Andrews

Chapter 14: Visible-Light-Mediated Organophotocatalytic Synthesis of Five-Membered N-Heterocycles

Md Tanjul Hoque, Prakash K. Mandal, Damayantee Dan, Rajjakfur Rahaman and Dilip K. Maiti

Six-Membered N-Heterocyclic Compounds:

Chapter 15: Recent Advances in Synthesis and Pharmacological Activities of Acridine Scaffold

Abhishek Tiwari, Varsha Tiwari, Devalina Ray and Bimal Krishna Banik

Index

Chemistry and Biology of Heterocycles Volume 2

List of Contributors

Editor Bios

Synthesis and Bioactivity of Heterocycles:

Sulphur, Oxygen & Related Heterocycles:

Chapter 16: Recent Advances in Synthetic Strategies, Mechanistic Aspects and Biological Insights of Furan and Thiophene Anchored Heterocycles

Ankita Garg, Pawan Deep Kaur Sani, Teesha Thakral and Aman Bhalla

Chapter 17: Synthesis and Biochemical Application of Benzofuran

M. Amin Mir, Syed M. Hasnain and K. Andrews

Chapter 18: Recent Advances in the Chemistry and Biology of Oxepines and Azepines

Rajat Ghosh, Manisha Kundu and Shital Kumar Chattopadhyay

Chapter 19: Chemistry and Biology of Naturally Occurring Dibenzo-alpha-pyrones

Asanjan Brahmachari and Goutam Brahmachari

Chapter 20: Synthetic and Biological Aspects in Selenium Heterocyclic Compounds

Shashikant Tiwari, Sangeeta Bajpai, Monika Kamboj and Shreya Dwivedi

Oxygen/Sulfur/Selenium-Functionalized Heterocycles:

Chapter 21: Investigating the Present Synthetic Strategies and Mechanistic Perspectives of Chalcogen (Oxo and Thio) Substituted Heterocycles with Biological Applications

Ankita Garg, Pawan Deep Kaur Sani, Rajat Dhiman and Aman Bhalla

Chapter 22: Synthetic Approaches to Selenium Containing/ Substituted Heterocyclic Compounds and Their Biological Relevance

Asha Rathee, Km Anjali, Ayush Islam, Devalina Ray, Sudeep Bose

Methods for Synthesis and Bioevaluation:

Chapter 23: An Update on Macrocyclization via Cross Coupling Strategy

Dripta De Joarder, Rajarshi Sarkar and Dilip K. Maiti

Chapter 24: Multistep Flow-Assisted Synthesis of N-Heterocyclic APIs: A Perception Of Modern Drug Discovery

Prakash K. Mandal, Md Tanjul Hoque, Rajesh Nandi, Antara Roy and Dilip K. Maiti

Chapter 25: Recent Advances in NHC Mediated Organocatalysis to Achieve Bioactive Heterocycles

Rajendra N. Mitra, Tanmoy Ghosh, Debabrata Barman, Satinath Sarkar and Dilip K. Maiti

Chapter 26: Chemistry, Synthesis and Uses of Deoxy Sugar Esters

Varsha Tiwari, Abhishek Tiwari, Bimal K. Banik

Chapter 27: Design and Therapeutic Potential of Heterocyclic Prodrugs

Km. Anjali, Suman Majee, Yashasvei Ahluwalia, Suman Mazumdar, Bimal K. Banik, Devalina Ray

Chapter 28: Quantitative Structure-Activity Relationships of Taxol and Related Compounds

Aparna Das and Bimal Krishna Banik

Index

Biography

Dr. Devalina Ray is an Assistant professor in Amity University, Noida, UP, India since October 2017. She has received her Ph.D from IIT Kharagpur, India in 2008. Thereafter, she pursued her postdoctoral research in University of Texas Medical Branch, Texas followed by University of Nebraska Medical Centre, Nebraska, USA. She joined Myongji University, Yongin as Research Professor and further continued her postdoctoral research in Hanyang University, Seoul, South Korea. She was employed as Research associate at IIT-Delhi and then continued to work there as Young Scientist till October 2017. Her research area included synthetic organic chemistry focused on transition metal-catalyzed and transition metal free C-H functionalization and cycloadditions, medicinal and natural product chemistry, green chemistry, peptide chemistry etc. The current area of interest deals with transition metal-free greener synthetic approaches to various coupling reactions and C-H functionalization. Dr. Ray is the recipient of “B. N. Mankad award from Indian Chemical Society, India. She is an affiliate member of Royal Chemical Society, CRSI, and editorial board member of American Journal of Heterocyclic Chemistry, Heterocyclic Letters and Asian J. Organic & Medicinal Chemistry. Recently, she has been recruited as the Executive Guest Editor of the journal Current Organocatalysis.

Professor Bimal K. Banik is a Professor of Prince Mohammad Bin Fahd University, Kingdom of Saudi Arabia. He was the Vice President of Research and Education Development of Community Health Systems of South Texas, a Tenured Full Professor and First President’s Endowed Professor at the University of Texas-Pan American Center for many years. Professor Banik was awarded Bachelor of Science Honors Degree in Chemistry from Itachuna Bejoy Narayan College and Master of Science Degree in Chemistry from Burdwan University. He obtained his Ph. D. degree based upon his thesis work performed at the Indian Association for the Cultivation of Science, Jadavpur, Calcutta. Dr. Banik was a Postdoctoral Fellow at Case Western Reserve University (Ohio) and Stevens Institute of Technology (New Jersey). He is a Fellow (FRSC) and Chartered Chemist (CChem) of the Royal Society of Chemistry and a Fellow of the Indian Chemical Society. Dr. Banik has been involved in organic and medicinal chemistry and biomedical research for many years. As Principal Investigator, he has been awarded $7.25 million USD grants from US National Institutes of Health, US National Cancer Institute, and US Kleberg Foundation. Professor Banik has 370 peer-reviewed publications along with 465 presentation abstracts. The number of citations of his publications is approximately 6400. He serves as a reviewer of 93, editorial board member of 28, editor-in-chief of 12, founder of 4, associate editor of 4 and guest editor of 6 journals.