1st Edition

Chemistry and Biology of Synthetic Retinoids

By Marcia I. Dawson Copyright 1990
    627 Pages
    by CRC Press

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    The purpose of this book is to present an overview of advances in both retinal and retinoic acid synthetic chemistry and biology. Chapters are written by research workers who are active in these fields. Emphasis is placed on structure-activity relationships. It includes topics of cell differentiation, maintenance of cell morphology, and vision. This reference contains a special section on assays which were developed to measure retinoid activity. This book is ideal for those interested in the fields of photobiology, organic chemistry, biological chemistry, and nutrition.

    1. The Bioorganic Chemistry of Vision 2. The Molecular Basis of the Visual Cycle 3. The Binding Site of Opsin Based on Analog Studies With Isomeric, Fluorinated, Alkylated, and Other Modified Retinals 4. Synthesis and Application of Retinoids and Related Compounds to Vision Research and Cancer Studies 5. Molecular Mechanism for the Function of Bacteriorhodopsin and Visual Pigments- Studies with Model Compounds and Artificial Pigments 6. Analog Pigments of Rhodopsin and Bacteriorhodopsin- Retinal Binding Site and Role of the Chromophore in the Function of These Pigment 7. Visual Pigment and Bacteriorhodopsin Analogs 8. Acetylenic Intermediates in Retinoid Synthesis 9. Synthesis and studies of 12-s-cis-Conformationally Locked Retinoids 10. The Biogenesis of Retinoic Acid- A physiologically Significant Promoter of Differentiation 11. Inhibition of Melanoma Cell Growth by Retinoids- Structure- Activity Relationships 12. Structure-Activity Relationships of a New Series of Synthetic Retinoids 13. Regulation of Squamous Differentiation in Tracheobronchial Epithelial Cells by Synthetic Retinoids 14. Structure-Biological Activity Relationships of New Synthetic Retinoids 15. Cellular Retinoic Acid-Binding Protein and the Action of Retinoic Acid 16. The Inhibitory Effects of Retinoids on the Induction of Ornithine Decarboxylase and the Promotion of Tumors in Mouse Epidermis 17. Role of Retinoids in Prevention of Cutaneous Cancer 18. Epidermal Responses to Retinoids in Vivo 19. Retinoid Inhibition of Experimental Carcinogenesis 20. Retinoids as Potential Antirheumatic Agents 21. Molecular Correlates in Retinoid Pharmacology and Toxicology 22. Carcinogenesis Inhibitory Properties of Retinoids- A QSAR -MTD Analysis


    Marcia I. Dawson