Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds: 1st Edition (Hardback) book cover

Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds

1st Edition

Edited by Goutam Brahmachari

CRC Press

584 pages | 662 B/W Illus.

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Natural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compoundspresents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities.

In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure–activity relationships.


"This title is of immense interest to researchers in the life sciences …[T]he book does provide more than 550 pages of information in 21 chapters focused on various compounds or classes thereof… In summary, most chapters of the book are well founded scientifically, with descriptions of recent research advances."

—John Thor Arnason, PhD, director of biopharmaceutical sciences, University of Ottawa, Ontario, Canada, in HerbalGram, The Journal of the American Botanical Council

‘This text could be used by phytochemists, medicinal chemists, and other natural products researchers. It is possible to be used by graduate students as a reference… Libraries supporting research or education efforts in natural products may find this beneficial for their reference shelf.’

Robert J. Krueger, Ferris St. University Big Rapids United States, for the J. Nat. Prod. 2018, 81, 216-216.

‘This interesting book written by eminent chemists expert in the extraction and synthesis of natural bioactive ingredients, reports the relationship between the structure-activity of different compounds, focusing the attention on the state-of-the-art of their pharmaceutical effectiveness and safeness. For the accuracy of chemical activities and methodologies of production and control of the natural products reported, the book may be of high utility for specialists of the chemical and medical community who like to deepen chemistry and pharmacology of the plant ingredients as well as for students in chemistry who desire to enter in this fascinating field.’

P. Morganti Ph.D. – Editor-in-Chief, J. Appl Cosmetol.35,183-186 (July/December 2017).

Table of Contents

Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds

Goutam Brahmachari

Impact of Solid-Supported Cyclization–Elimination Strategies toward the Development of Natural Product Inspired Molecules in Drug Discovery Research

Dhananjay Kumar, Bhuwan B. Mishra, Divya Kushwaha, and Vinod K. Tiwari

Synthesis and Biological Studies of Novel β-Lactams Bimal K. Banik

Applications of Isatin Chemistry in Organic Synthesis and Medicinal Chemistry

Girija S. Singh and Zelalem Y. Desta

Role of Organic Carbamates in Anticancer Drug Design

Devdutt Chaturvedi

Rational Design of New Molecules of Biological Significance from Phenolic Constituents of Some Tropical Plants as Renewable Materials

Vladimir V. Kouznetsov, Diego R. Merchan Arenas, Fernando A. Rojas Ruiz,

and Leonor Y. Vargas Méndez

Synthesis and Biological Activity of Promising Azole Marine Products: Largazole and Neopeltolide

Danilo Davyt and Gloria Serra

Omega-3 (ω-3) Polyunsaturated Fatty Acids Philip C. Calder

Structure and Biological Activity of Natural Melanin Pigments

Krystyna Stępień, Anna Dzierżęga-Lęcznar, Irena Tam, and Slawomir Kurkiewicz

Recent Acquisitions on Naturally Occurring Oxyprenylated Secondary Plant Metabolites

Francesco Epifano and Salvatore Genovese

Role of Curcumin in Ameliorating Neuroinflammation and Neurodegeneration Associated with Alzheimer’s Disease

Sumit Sarkar, Balmiki Ray, Jay Sharma, Larry Schmued, and Debomoy K. Lahiri

Plant Metabolites

Marina P. Polovinka and Nariman F. Salakhutdinov

X-Ray Structural Behavior of Some Significant Bioactive Steroids and Their Chemistry in the Crystal Packing and Related Matters

Vivek K. Gupta

Three-Dimensional Structure of Xanthones

Luís Gales and Ana M. Damas

Gambogic Acid

Goutam Brahmachari

Neuroplasticity as a New Approach to the Pathophysiology of Depression and the Role of Antidepressants in Inhibiting Brain Stress-Induced Changes

Gianluca Serafini, Maurizio Pompili, and Paolo Girardi


Vincent Gullo and Arnold L. Demain

Molecular Aspects of Fungal Bioactive Polyketides

Ira Bhatnagar and Se-Kwon Kim

Marine Microalgal Metabolites

S.W.A. Himaya and Se-Kwon Kim

Rosmarinic Acid

Juan C. Luis, Maria Y. González-Padrón, Raquel M. Pérez, Ignacio F. Viera, and Francisco V. González

Enhancement of Natural Antioxidants in Plants by Biosynthetic Pathway Modulation

Kanakapura K. Namitha and Pradeep S. Negi

Plant as Biofactories of Pharmaceuticals and Nutraceuticals

Dandara R. Muniz, Raquel de Oliveira Faria, Vagner Augusto Benedito, Ângelo de Fátima, and Luzia Valentina Modolo

About the Editor

Goutam Brahmachari, Ph.D. is an Associate Professor within the Laboratory of Natural Products and Organic Synthesis, Department of Chemistry, at Visva-Bharati University, India.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
SCIENCE / Chemistry / General