1st Edition

Chitin and Chitosan Derivatives Advances in Drug Discovery and Developments

Edited By Se-Kwon Kim Copyright 2014
    527 Pages 193 B/W Illustrations
    by CRC Press

    A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field.

    Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers. Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing.

    A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.

    Part I Synthesis and Characterization of Chitin and Chitosan Derivatives

    Chitin and Chitosan Derivatives
    Se-Kwon Kim and Jayachandran Venkatesan

    Synthesis, Characterization, and Biomedical Applications of Chitosan and Its Derivatives
    Hans E. Junginer and Assal M. M. Sadeghi

    Utilization of Silyl Ethers and Other Protection Groups in the Synthesis of Chitosan Derivatives
    Vivek S. Gaware, Berglind Eva Benediktsdóttir, and Már Másson

    Chemical Aspects of Chitin and Chitosan Derivatives
    Hitoshi Sashiwa

    Preparation of Chitin and Chitosan Derivatives Having Mercapto Groups
    Mónica Perez, Alberto Gallardo, Juan Alfonso Redondo, and Inmaculada Aranaz

    Thiolated Chitosan: Preparation, Properties, and Applications
    Nazma N. Inamdar and Vishnukant Mourya

    Graft Copolymerization of Acrylic Monomers on Chitosan and Its Derivatives: Recent Developments and Applications
    M. Prabaharan

    Preparation of Chitin Nanofibers for Biomedical Application
    Shinsuke Ifuku, Hiroyuki Saimoto, Kazuo Azuma, Tomohiro Osaki, and Saburo Minami

    Part II Biological Activities of Chitin and Chitosan Derivatives

    Anticancer Effects of Chitin and Chitosan Derivatives
    Mustafa Zafer Karagozlu, Fatih Karadeniz, and Se-Kwon Kim

    Antidiabetic Applications of Chitosan and Its Derivatives
    Fatih Karadeniz and Se-Kwon Kim

    Antioxidant, Antimicroorganism of Chitin, Chitosan, and Their Derivatives
    Dai-Nghiep Ngo and Se-Kwon Kim

    Role of Chitosan and Its Derivatives in Cardiovascular Health
    Dai-Hung Ngo and Se-Kwon Kim

    Biological Applications of Chitin, Chitosan, Oligosaccharides, and Their Derivatives
    Panchanathan Manivasagan, Kalimuthu Senthilkumar, Jayachandran Venkatesan, and Se-Kwon Kim

    Chitin and Chitosan Derivatives for Wound-Healing Applications
    Willi Paul, R. Deepa, T. V. Anilkumar, and Chandra P. Sharma

    Part III Biomedical Applications of Chitin and Chitosan Derivatives

    Chitosan: Amazing Controlled Delivery System
    Maher Z. Elsabee and Rania E. Morsi

    Modifications of Chitosan for Gene Delivery
    Bijay Singh, Sushila Maharjan, Sang-Ki Kang, Yun-Jaie Choi, Myung-Haing Cho, and Chong-Su Cho

    Prospective Corollary of Ophthalmic Nanomedicine: A Concept Shift toward Chitosan-Based Mucoadhesive Nanomedicine
    Farhan Jalees Ahmad, Sohail Akhter, Mohammad Zaki Ahmad, Farshad Ramazani, Mohammad Samim, Musarrat Husain Warsi, Mohammad Anwar, and Ziyaur Rahman

    Biomedical Applications of Chitin and Chitosan Derivatives
    Sougata Jana, Arijit Gandhi, Kalyan Kumar Sen, and Sanat Kumar Basu

    Chitosan Derivatives for Oral Delivery of Insulin
    Anumita Chaudhury and Surajit Das

    Chitosan and Chitosan Derivatives for Mucosal Delivery of Biopharmaceutical Drugs
    Fernanda Andrade, Francisca Araújo, and Bruno Sarmento

    Chitosans as Delivery Vectors in Biomedical Applications
    Vandana Patravale and Swati Vyas

    Chitosan as Coating Material for Titanium Implants
    Ramona Lieder and Olafur E. Sigurjonsson

    Current Scenario and Future Prospects of Chitosan in Dentistry
    Manal Farea, Ahmad Sukari Halim, and Nor Shamsuria Omar

    Bionanocomposites of Chitosan for Multitissue Engineering Applications
    P. N. Sudha, S. Aisverya, Maximas H. Rose, Jayachandran Venkatesan, and Se-Kwon Kim

    Recent Advancements in Research on Chitin and Chitosan Derivatives for Drug Delivery Application
    P. N. Sudha, T. Gomathi, K. Nasreen, Jayachandran Venkatesan, and Se-Kwon Kim

    Chitosan and Chitosan Derivatives as Potential Adjuvants for Influenza Vaccine
    Nguyen Anh Dzung


    Professor Se-Kwon Kim, Ph.D., is a senior professor in the Department of Chemistry and is the director of the Marine Bioprocess Research Center (MBPRC) at Pukyong National University in the Republic of Korea. His major research interests include investigation and development of bioactive substances derived from marine organisms and their application in Oriental medicine, nutraceuticals, and cosmeceuticals via marine bioprocessing and mass-production technologies. He is a board member of the International Society of Marine Biotechnology and the International Society for Nutraceuticals and Functional Foods. To date, he has authored more than 500 research papers, holds 110 patents, and has written or edited more than 40 books.

    "Chitin and Chitosan Derivatives provides the reader with access to a wealth of relevant research, making it an excellent reference volume for students and researchers in both academia and industry with interests in the production and use of modified biopolymers for biological or biomedical applications."
    —Charles J. Knill, Chembiotech Laboratories, and John F. Kennedy, in Carbohydrate Polymers