Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments, 1st Edition (Hardback) book cover

Chitin and Chitosan Derivatives

Advances in Drug Discovery and Developments, 1st Edition

Edited by Se-Kwon Kim

CRC Press

527 pages | 193 B/W Illus.

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pub: 2013-12-04
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Description

A natural long-chain polymer, chitin is the main component of the cell walls of fungi, the exoskeletons of arthropods (including crustaceans and insects), the radulas of mollusks, and the beaks and internal shells of cephalopods. However, marine crustacean shells are the primary sources of the chitin derivative chitosan. Chitin and chitosan are useful for various biological and biomedical applications, although they have been limited by poor solubility in the past. Current research focuses on increasing their solubility and bioactivity through molecular modifications. The resulting derivatives are receiving much attention for interesting properties, such as biocompatibility, biodegradability, and nontoxicity, that make them suitable for use in the biomedical field.

Chitin and Chitosan Derivatives: Advances in Drug Discovery and Developments presents current research trends in the synthesis of chitin and chitosan derivatives, their biological activities, and their biomedical applications. Part I discusses basic information about the synthesis and characterization of a variety of derivatives, including the preparation of chitin nanofibers. Part II covers chitin and chitosan modifications as the basis for biological applications. It describes antioxidant, anti-inflammatory, anticancer, antiviral, anticoagulant, and antimicrobial activities. Part III addresses chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and wound dressing.

A must-have reference for novices and experts in biotechnology, natural products, materials science, nutraceuticals, and biomedical engineering, this book presents a wide range of biological and biomedical applications of chitin and chitosan derivatives for drug discovery and development.

Reviews

"Chitin and Chitosan Derivatives provides the reader with access to a wealth of relevant research, making it an excellent reference volume for students and researchers in both academia and industry with interests in the production and use of modified biopolymers for biological or biomedical applications."

—Charles J. Knill, Chembiotech Laboratories, and John F. Kennedy, in Carbohydrate Polymers

Table of Contents

Part I Synthesis and Characterization of Chitin and Chitosan Derivatives

Chitin and Chitosan Derivatives

Se-Kwon Kim and Jayachandran Venkatesan

Synthesis, Characterization, and Biomedical Applications of Chitosan and Its Derivatives

Hans E. Junginer and Assal M. M. Sadeghi

Utilization of Silyl Ethers and Other Protection Groups in the Synthesis of Chitosan Derivatives

Vivek S. Gaware, Berglind Eva Benediktsdóttir, and Már Másson

Chemical Aspects of Chitin and Chitosan Derivatives

Hitoshi Sashiwa

Preparation of Chitin and Chitosan Derivatives Having Mercapto Groups

Mónica Perez, Alberto Gallardo, Juan Alfonso Redondo, and Inmaculada Aranaz

Thiolated Chitosan: Preparation, Properties, and Applications

Nazma N. Inamdar and Vishnukant Mourya

Graft Copolymerization of Acrylic Monomers on Chitosan and Its Derivatives: Recent Developments and Applications

M. Prabaharan

Preparation of Chitin Nanofibers for Biomedical Application

Shinsuke Ifuku, Hiroyuki Saimoto, Kazuo Azuma, Tomohiro Osaki, and Saburo Minami

Part II Biological Activities of Chitin and Chitosan Derivatives

Anticancer Effects of Chitin and Chitosan Derivatives

Mustafa Zafer Karagozlu, Fatih Karadeniz, and Se-Kwon Kim

Antidiabetic Applications of Chitosan and Its Derivatives

Fatih Karadeniz and Se-Kwon Kim

Antioxidant, Antimicroorganism of Chitin, Chitosan, and Their Derivatives

Dai-Nghiep Ngo and Se-Kwon Kim

Role of Chitosan and Its Derivatives in Cardiovascular Health

Dai-Hung Ngo and Se-Kwon Kim

Biological Applications of Chitin, Chitosan, Oligosaccharides, and Their Derivatives

Panchanathan Manivasagan, Kalimuthu Senthilkumar, Jayachandran Venkatesan, and Se-Kwon Kim

Chitin and Chitosan Derivatives for Wound-Healing Applications

Willi Paul, R. Deepa, T. V. Anilkumar, and Chandra P. Sharma

Part III Biomedical Applications of Chitin and Chitosan Derivatives

Chitosan: Amazing Controlled Delivery System

Maher Z. Elsabee and Rania E. Morsi

Modifications of Chitosan for Gene Delivery

Bijay Singh, Sushila Maharjan, Sang-Ki Kang, Yun-Jaie Choi, Myung-Haing Cho, and Chong-Su Cho

Prospective Corollary of Ophthalmic Nanomedicine: A Concept Shift toward Chitosan-Based Mucoadhesive Nanomedicine

Farhan Jalees Ahmad, Sohail Akhter, Mohammad Zaki Ahmad, Farshad Ramazani, Mohammad Samim, Musarrat Husain Warsi, Mohammad Anwar, and Ziyaur Rahman

Biomedical Applications of Chitin and Chitosan Derivatives

Sougata Jana, Arijit Gandhi, Kalyan Kumar Sen, and Sanat Kumar Basu

Chitosan Derivatives for Oral Delivery of Insulin

Anumita Chaudhury and Surajit Das

Chitosan and Chitosan Derivatives for Mucosal Delivery of Biopharmaceutical Drugs

Fernanda Andrade, Francisca Araújo, and Bruno Sarmento

Chitosans as Delivery Vectors in Biomedical Applications

Vandana Patravale and Swati Vyas

Chitosan as Coating Material for Titanium Implants

Ramona Lieder and Olafur E. Sigurjonsson

Current Scenario and Future Prospects of Chitosan in Dentistry

Manal Farea, Ahmad Sukari Halim, and Nor Shamsuria Omar

Bionanocomposites of Chitosan for Multitissue Engineering Applications

P. N. Sudha, S. Aisverya, Maximas H. Rose, Jayachandran Venkatesan, and Se-Kwon Kim

Recent Advancements in Research on Chitin and Chitosan Derivatives for Drug Delivery Application

P. N. Sudha, T. Gomathi, K. Nasreen, Jayachandran Venkatesan, and Se-Kwon Kim

Chitosan and Chitosan Derivatives as Potential Adjuvants for Influenza Vaccine

Nguyen Anh Dzung

About the Editor

Professor Se-Kwon Kim, Ph.D., is a senior professor in the Department of Chemistry and is the director of the Marine Bioprocess Research Center (MBPRC) at Pukyong National University in the Republic of Korea. His major research interests include investigation and development of bioactive substances derived from marine organisms and their application in Oriental medicine, nutraceuticals, and cosmeceuticals via marine bioprocessing and mass-production technologies. He is a board member of the International Society of Marine Biotechnology and the International Society for Nutraceuticals and Functional Foods. To date, he has authored more than 500 research papers, holds 110 patents, and has written or edited more than 40 books.

Subject Categories

BISAC Subject Codes/Headings:
MED072000
MEDICAL / Pharmacy
SCI013000
SCIENCE / Chemistry / General
SCI039000
SCIENCE / Life Sciences / Biology / Marine Biology