Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence, 1st Edition (Paperback) book cover

Cholesterol-Lowering Therapy

Evaluation of Clinical Trial Evidence, 1st Edition

Edited by Scott M. Grundy

CRC Press

352 pages

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pub: 2019-09-19
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pub: 1999-11-05
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Description

Reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States.

This timely reference reviews the vast body of clinical trial evidence supporting the once controversial view that high levels of serum cholesterol are a major risk factor in coronary heart disease (CHD). The studies presented in Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence promote cholesterol reduction as a highly successful means of preventing heart disease in various populations.

Investigates past, current, and upcoming controlled clinical trials of cholesterol-reduction therapies, comparing effects of statins and bile acid sequestrants to triglyceride-lowering drugs and antioxidants.

Written by more than 25 distinguished international researchers, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence

  • highlights historical studies of dietary trials designed to reduce CHD

  • covers tests of HMG CoA reductase inhibitors for patients with and without CHD

  • illuminates CHD risk factors such as diabetes, hypertension, obesity, and smoking

  • explores blood levels of homocysteine and lipoprotein(a) and other recently identified CHD risk factors

  • reviews metabolism of lipoproteins expressed in high (HDL) and low (LDL) density lipoprotein cholesterol

  • and more!

    Containing over 700 instructive tables, drawings, photographs, and bibliographic citations, Cholesterol-Lowering Therapy: Evaluation of Clinical Trial Evidence is a must-read resource for cardiologists, pharmacologists, and upper-level undergraduate, graduate, and medical school students in these disciplines.

  • Table of Contents

    Cholesterol-Lowering Clinical Trials: A Historical Perspective

    Scott M. Grundy

    Scandinavian Simvastatin Survival Study (4S)

    Terje R. Pedersen

    The Cholesterol and Recurrent Events Trial (CARE): The Effect of Pravastatin on Coronary Events After Myocardial Infarction in Patients with Average Cholesterol Levels

    Frank M. Sacks, Marc A. Pfeffer, Lemuel A. Moyé, C. Morton Hawkins, Barry R. Davis, Jean L. Rouleau, Thomas G. Cole, and Eugene Braunwald

    Lessons from the West of Scotland Coronary Prevention Study (WOSCOPS)

    James Shepherd and Allan Gaw

    Program on the Surgical Control of the Hyperlipidemias (POSCH) Trial: A Pivotal 25-Year Study

    Henry Buchwald

    The Air Force/Texas Atherosclerosis Prevention Study (AFCAPS/TexCAPS): Primary Prevention of Acute Major Coronary Events in Women and Men with Average Cholesterol

    Stephen Weis, Michael Clearfield, Lt. Col. John R. Downs, and Antonio M. Gotto, Jr.

    Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study: Clinical Implications for Cardiovascular Practice

    Andrew M. Tonkin and David Hunt

    Angiographic Results of Lipid-Lowering Trials: A Systematic Review and Meta-Analysis

    Cheryl L. Holmes, Michael Schulzer, and G. B. John Mancini

    Biochemical Correlates of Plaque Progression and Coronary Events

    Melissa Ferraro-Borgida and David Waters

    Lipid Therapy to Stabilize the Vulnerable Atherosclerotic Plaque: New Insights into the Prevention of Cardiovascular Events

    B. Greg Brown and Xue-Qiao Zhao

    Cholesterol-Lowering Trials with Carotid Ultrasonographic Outcomes

    Robert P. Byington

    Cholesterol Lowering Reduces Mortality: The Statins

    David J. Gordon

    About the Editor

    Scott M. Grundy

    Subject Categories

    BISAC Subject Codes/Headings:
    MED060000
    MEDICAL / Nutrition
    MED071000
    MEDICAL / Pharmacology
    SCI086000
    SCIENCE / Life Sciences / General