1st Edition

Chronic Allograft Failure Natural History, Pathogenesis, Diagnosis and Management

By Nasimul Ahsan Copyright 2008
    368 Pages 126 B/W Illustrations
    by CRC Press

    This book addresses one of the largest unmet needs in transplantation, the need to reduce late allograft loss. In the current era, it is reasonable to expect that most allografts will serve their recipients through their life span and death with preserved graft function the ultimate goal for all transplant recipients. However, long term allograft survival has not paralleled improvements made in short term survival. Each year a percentage of the existing organ transplant patients will lose their grafts. The problem of late allograft failure is due in part to pathogenic processes, to drug management, and to transplant patient care delivery. This book pulls together the science in this area and serves as a resource and as a catalyst for further research. The book has been divided into sections covering the entirety of chronic allograft loss from basic science consideration to clinical implications. The goal of this book is to provide the reader with an overview of long term problems in solid organ transplantation. This overview not only includes the diagnosis of immunologic and non-immunologic causes of chronic graft loss but current management as well as novel therapies for future application. This book will make a useful contribution to the literature.

    Preface Section I. Introduction 1. Introducing Chronic Graft Failure 2. Chronic Allograft Failure: Past, Present and Future 3. Solid Organ Transplantation—An Overview 4. Analyzing Graft Failure in the Scientific Registry of Transplant Recipients: The Sources and Nature of the Data Available 5. The Immunology of Chronic Allograft Injury 6. Ischemia-Reperfusion Injury: Pathophysiology and Clinical Approach 7. Heat Shock Protein 47 in Chronic Allograft Nephropathy 8. Dendritic Cell-Based Approaches to Organ Transplantation Section II. Heart 9. Cardiac Allograft Vasculopathy 10. The Pathology of Heart Allograft Rejection 11. Experimental Gene Therapy of Heart Transplantation Section III. Lung 12. The Basic Science of Lung Allograft Failure 13. The Role for Cytokine Responses in the Pathogenesis of Lung Allograft Dysfunction 14. Diagnosis of Chronic Graft Failure after Lung Transplantation 15. Treatment of Chronic Graft Failure after Lung Transplantation Section IV. Liver 16. Liver Transplantation—An Overview 17. Hepatic Allograft Loss: Pathogenesis, Diagnosis and Management 18. Chronic Allograft Dysfunction—Liver 19. Liver Graft Loss Due to Vascular Complications 20. Late Allograft Failure: Liver 21. Liver Allograft Failure Due to Recurrent Disease—Pathology Section V. Intestine Transplant 22. Chronic Allograft Enteropathy Section VI. Kidney 23. Renal Allograft Survival: Epidemiologic Considerations 24. Predictive Parameters of Renal Graft Failure 25. Clinico-Pathological Correlations of Chronic Allograft Nephropathy 26. Recurrent Glomerular Disease in the Allograft: Risk Factors and Management 27. Pathology of Kidney Allograft Dysfunction Section VII. Islet Cell 28. Islet of Langerhans; Cellular Structure and Physiology 29* Islet Transplantation 30. Metabolic Indicators of Islet Graft Dysfunction Section VIII. Pancreas 31. Pancreas and Islet Allograft Failure 32. Chronic Pancreas Allograft Failure 33. Pathological Aspects of Pancreas Allograft Failure Section IX. Infectious Disease 34. The Graft: Emerging Viruses in Transplantation 35. Cytomegalovirus and Allograft Failure after Solid Organ Transplantation 36. Hepatitis C Virus Infection as a Risk Factor for Graft Loss after Renal Transplantation 37. Polyomavirus Type BK-Associated Nephropathy and Renal Allograft Graft Loss: Natural History, Patho-Physiology, Diagnosis and Management 38. Polyomavirus Allograft Nephropathy: Clinico-Pathological Correlations Section X Pharmacotherapy 39. Pharmacotherapeutic Options in Solid Organ Transplantation


    Nasimul Ahsan, is a Professor of Medicine of Mayo Clinic - College of Medicine and a Consultant of Mayo Clinic Transplant Center, Jacksonville, USA. His main research interests include transplant immunology and immunosuppressive management of transplant patients. He has authored numerous peer-reviewed articles and previously edited a book entitled Polyomaviruses and Human Diseases. He is a member of several national and international scientific organizations.