1st Edition

Chronic Lung Disease in Early Infancy

  • This format is currently out of stock.
ISBN 9780824798710
Published September 21, 1999 by CRC Press
1096 Pages

USD $260.00

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Book Description

This definitive volume presents the clinical and pathological features of bronchopulmonary dysplasia, a disease that accounts for the majority of long-term hospitalizations, slow growth, and recurrent early childhood respiratory ailments that are common in low-birth-weight newborns.
Highlights relevant animal models for studying the process of chronic lung disease through its evolution and during recovery!
Written by nearly 75 leading international authorities on lung disease during early childhood development who describe the clinical, radiographic, and pathological changes that have occurred in the 30 years since bronchopulmonary dysplasia was first discovered, Chronic Lung Disease in Early Infancy

  • focuses on the development of technology, notably changes in the application of assisted ventilation
  • traces the evolution and impact of new therapies, including prenatal glucocorticoids and postnatal surfactants
  • suggests effective therapeutic and preventive strategies
  • explains how the lungs develop structurally and functionally
  • explores how lung development is altered by injury and the repair process
  • critically examines research in the field of pediatric lung pathology
  • reviews what is known and emphasizes what needs to be learned about bronchopulmonary dysplasia
  • provides direction for future research into chronic lung disease
  • and more!
  • Table of Contents

    Clinical Aspects

    Historical Perspective: Early Observations and Subsequent Evolution of Bronchopulmonary Dysplasia
    William H. Northway, Jr.
    Epidemiology of Bronchopulmonary Dysplasia: Clinical Risk Factors and Associated Clinical Conditions
    Alma Martinez, Peter Dargaville, and H. William Taeusch
    Clinical Course and Lung Function Abnormalities During Development of Neonatal Chronic Lung Disease
    Eduardo Bancalari and Alvaro Gonzalez
    Radiographic Features of BPD and Potential Application of New Imaging Techniques
    David K. Edwards and William H. Northway, Jr.
    Pathology of Chronic Lung Disease of Early Infancy
    Jacqueline J. Coalson
    The Usefulness of Bronchoalveolar Lavage in Infants with Evolving Chronic Lung Disease
    Carl W. White and Leland L. Fan
    Inflammatory Mediators in Neonatal Lung Disease
    Christian P. Speer and Peter Groneck
    Infection in the Pathogenesis of Bronchopulmonary Dysplasia
    William E. Benitz and Ann M. Arvin
    Ventilation Strategies and Bronchopulmonary Dysplasia
    W. Alan Hodson
    Effect of Respiratory Care Practices on the Development of Bronchopulmonary Dysplasia
    Michael R. Gomes and Thomas N. Hansen
    Influence of Surfactant Replacement on Development of Bronchopulmonary Dysplasia
    Alan H. Jobe
    Drug Treatment for Established BPD
    Thomas A. Hazinski
    Nutritional Issues in Chronic Lung Disease of Premature Infants
    Ilene R. S. Sosenko, Michael T. Kinter, and Robert J. Roberts
    Pulmonary Function in BPD and Its Aftermath
    Eric C. Eichenwald
    Cardiovascular Abnormalities in Bronchopulmonary Dysplasia
    Michael Apkon, Rodrigo Nehgme, and George Lister
    Long-Term Recovery from Bronchopulmonary Dysplasia
    Solomon Alkrinawi and Victor Chernick
    The Goal: Prevention of BPD
    Mildred T. Stahlman

    Normal and Abnormal Alveolar and Airway Development

    Unique Features of the Immature Lung that Make It Vulnerable to Injury
    Scott H. Randell and Stephen L. Young
    Hormonal Effects on Lung Maturation and Disease
    Philip L. Ballard and Roberta A. Ballard
    Mechanisms and Physiological Sequelae of Reactive Species Injury to the Alveolar Epithelium
    Imad Y. Haddad, Sha Zhu, Samuel J. Tilden, and Sadid Matalon
    Surfactant in Chronic Lung Injury
    Richard J. King and Samuel Hagwood
    The Regulation of the Formation of Pulmonary Alveoli
    Donald J. Massaro and Gloria D. Massaro
    Factors Mediating Cell Growth in Lung Injury
    A. Keith Tanswell, Shilpa Buch, Mingyao Liu, and Martin Post
    Developmental Airway Structure and Function in Health and Chronic Lung Injury
    Howard B. Panitch and Thomas H. Shaffer

    Normal and Abnormal Development of the Lung Circulation and Interstitium

    Lung Development and the Effects of Chronic Hypoxia
    Sheila G. Haworth
    Altered Development of the Pulmonary Circulation in Chronic Lung Injury
    Marlene Rabinovitch
    Pulmonary Hypertension in Chronic Lung Disease of Infancy: Pathogenesis, Pathophysiology, and Treatment
    Steven H. Abman
    Connective Tissues in Lung Development and Diseases in Early Infancy
    David J. Riley
    Pulmonary Edema After Premature Birth: Progression from Acute to Chronic Lung Disease
    Richard D. Bland and David P. Carlton

    Mechanisms of Lung Injury and Repair During Development

    Molecular Mechanisms of Oxygen-Induced Lung Injury
    Charles Vincent Smith and Stephen E. Welty
    Assessment of Tissue Injury from Reactive Oxygen Metabolites
    Michael J. Thomas, Timothy W. Robison, and Henry Jay Forman
    Chronic Lung Disease of Early Infancy: Role of Neutrophils
    Diane E. Lorant, Kurt Albertine, and John F. Bohnsack
    The Role of Pulmonary Macrophages in Chronic Lung Disease of Early Infancy
    Michael P. Sherman and William E. Truog
    Oxidants and Antioxidants: What Role Do They Play in Chronic Lung Disease
    H. Lee Frank and Ilene R. S. Sosenko
    Proteolytic Enzymes and Their Inhibitor in Lung Health and Disease
    John R. Hoidal and Mari K. Hoidal
    Site and Mechanism-Directed Interventions for Tissue Free Radical Injury
    William R. Berrington, Margaret M. Tarpey, Bruce A. Freeman, and Bruce R. Pitt

    Models of Lung Injury and Repair During Development

    Genetic Models for the Study of Autocrine-Paracrine Signaling in Lung Development and Repair
    Jeffrey A. Whitsett and Thomas R. Korfhagen
    Animal Models of Chronic Lung Injury
    Jacqueline J. Coalson, Steven R. Seidner, and Robert A. De Lemos

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    ...describes the clinical, radiographic, and pathologic changes that have occurred since the discovery of bronchopulmonary dysplasia 30 years ago....highlights include...animal models that can be used to study the process of chronic lung disease through its evolution and during recovery.
    "-Pulmonary Reviews

    ...an extensive and detailed review of bronchopulmonary dysplasia.
    -Doody's Health Sciences Book Reviews

    "…clearly written….
    …an extremely valuable source of information for anyone who has an interest in the biology of lung….
    …should be available in the library of any hospital.
    "-Respiratory Care

    "…valuable and well organized….
    ..should be an essential book for any chemist working in the area of solid state electrochemistry.
    "-Journal of Solid State Electrochemistry