2nd Edition

Chronic Lymphoid Leukemias

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ISBN 9780824705435
Published April 25, 2001 by CRC Press
664 Pages

USD $250.00

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Book Description

Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters!

Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering all major developments since the previous edition was published eight years ago.

Chronicling the complete history and variations of CLL-type leukemia, the Second Edition

  • reviews the origin, nature, and molecular differences between B-CLL and T-CLL/PLL leukemias
  • analyzes core constituents of apoptosis and causes for dysregulation of programmed cell death (PCD) in B-CLL
  • examines recent research on the role cytokines and regulatory molecules may play in cross-cell communication
  • profiles commonly used vectors for somatic gene therapy, as well as the latest advances in genetic engineering and vector design and production
  • utilizes up-to-the-minute techniques such as fluorescence in-situ hybridization (FISH) and comparative genomic hybridization (CGH) to detect genetic abnormalities and aberrations
  • explores current measures of supportive care with splenectomy, cytokine proteins, and intravenous immunoglobulin applications
  • identifies how to manage infectious and psychiatric complications in patients with CLL
  • and much more!
    Provides contemporary results on the efficacy of nucleoside analog combinations such as ara-C with fludarabine and cladribine and on the emerging nucleosides nelarabine and clofarabine!

    Copiously supplemented with over 2500 literature references-1000 more than the first edition-Chronic Lymphoid Leukemias, Second Edition fulfills the reference needs of oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.
  • Table of Contents

    History of Chronic Lymphocytic Leukemia
    Kanti R. Rai and Tarun Wasil
    Molecular Biology of Chronic Lymphocytic Leukemia
    Florencia Bullrich and Carlo M. Croce
    Chronic Lymphocytic Leukemia: Epidemiological, Familial, and Genetic Aspects
    Maria T. Sgambati, Martha S. Linet, and Susan S. Devesa
    The Origin and Nature of the Chronic Lymphocytic Leukemia Lymphocyte
    Paolo Ghia and Federico Caligaris-Cappio
    Immunoglobulin Variable Region Gene Characteristics and Surface Membrane Phenotype Define B-CLL Subgroups with Distinct Clinical Courses
    Nicholas Chiorazzi and Manlio Ferrarini
    Apoptosis Dysregulation in Chronic Lymphocytic Leukemia
    John C. Reed and Shinichi Kitada
    Cytokines and Regulatory Molecules in the Pathogenesis and Clinical Course of B-Cell Chronic Lymphocytic Leukemia
    Enrica Orsini and Robin Foa
    Randomized Trials: What Do They Teach us About Chronic Lymphocytic Leukemia Treatment?
    G. Dighiero
    Genetic Approaches to the Therapy of Chronic Lymphocytic Leukemia
    Thomas J. Kipps
    Combination Strategies for Purine Nucleoside Analogs
    Varsha Gandhi and William Plunkett
    Differential Diagnosis of the Chronic B-Cell Lymphoid Leukemias
    Randy D. Gascoyne
    Prognostic Factors in Chronic Lymphocytic Leukemia
    Stefano Molica
    Initial Approach to the Patient with Chronic Lymphocytic Leukemia
    Bruce D. Cheson
    Management of the Patient with Relapsed or Refractory Chronic Lymphocytic Leukemia
    Deborah A. Thomas, Susan M. O'Brien, and Michael J. Keating
    The Use of Therapeutic Monoclonal Antibodies in Chronic Lymphocytic Leukemia
    Martin J. S. Dyer and Anders Österborg
    Genomic Aberrations in B-Cell Chronic Lymphocytic Leukemia
    Stephan Stilgenbauer, Peter Lichter, and Hartmut Döhner
    Developing Risk-Adapted Treatment Strategies for Chronic Lymphocytic Leukemia
    Emilio Montserrat
    High-Dose Therapy and Stem Cell Support in Chronic Lymphocytic Leukemia
    Angela M. Krackhardt and John G. Gribben
    Finding New Therapies for Patients with Chronic Lymphocytic Leukemia
    John C. Byrd and Michael R. Grever
    Autoimmune Disease and Its Management in Chronic Lymphocytic Leukemia
    Terry Hamblin
    Richter's Syndrome
    John Seymour and Janine Campbell
    Supportive Care in Chronic Lymphocytic Leukemia
    Farhad Ravandi, Michael J. Keating, and Susan M. O'Brien
    Infections in Patients with Chronic Lymphocytic Leukemia: Pathogenesis, Spectrum, and Therapeutic Approaches
    Vicki A. Morrison
    Prolymphocytic Leukemia of B- and T-Cell Types: Biology and Therapy
    Estella Matutes, Vasantha Brito-Babapulle, Claire Dearden, M. R. Yullie, and Daniel Catovsky
    Chronic T-Cell and NK-Cell Leukemias
    Edgar G. Miranda and Thomas P. Loughran, Jr.
    Current Concepts in the Management of Hairy Cell Leukemia
    Martin S. Tallman, Mark A. Hoffman, and LoAnn C. Peterson
    Psychological Aspects of Chronic Lymphoid Leukemia
    Jahandar Saifollahi, Marjaneh Rouhani, Andrew J. Roth, and Jimmie C. Holland

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    Praise for the first edition…

    An informative, up-to-date, well-referenced, and user-friendly text.
    With an illustrious cadre of authors, Cheson has crafted together state-of-the-art reviews...
    …a valuable addition to reference libraries…this compendium meets the need for an excellent reference text on CLL."-Hematologic Pathology
    "…[an] important book.
    …well written and edited….the editor deserves praise for…fostering a general sense of continuity."-The New England Journal of Medicine
    "…of great value to hematologists and oncologists….readers will learn a lot about the recent progress in CLL."-International Journal of Hematology
    "…a valuable contribution in bringing together disparate aspects of biology and clinical management of CLL….a useful compendium."-Australian Cancer Society

    "…should be ready by everyone taking care of pediatric patients with chronic lymphocytic leukemia (CLL)…up-to-date….an excellent, comprehensive review of the current treatment modalities….
    …the best review of CLL and related diseases currently available.
    "-Annals of Oncology