Chronic Lymphoid Leukemias: 2nd Edition (Hardback) book cover

Chronic Lymphoid Leukemias

2nd Edition

By Bruce D. Cheson

CRC Press

664 pages

Purchasing Options:$ = USD
Hardback: 9780824705435
pub: 2001-04-25
Currently out of stock
eBook (VitalSource) : 9780429092473
pub: 2001-04-25
from $28.98

FREE Standard Shipping!


Written by over 50 internationally distinguished experts, 30 more than the first edition, and contains nine new chapters!

Continuing in the esteemed tradition and heralded success of the first edition, Chronic Lymphoid Leukemias, Second Edition offers a full overview of chronic lymphocytic leukemia (CLL) from multiple perspectives-covering all major developments since the previous edition was published eight years ago.

Chronicling the complete history and variations of CLL-type leukemia, the Second Edition

  • reviews the origin, nature, and molecular differences between B-CLL and T-CLL/PLL leukemias

  • analyzes core constituents of apoptosis and causes for dysregulation of programmed cell death (PCD) in B-CLL

  • examines recent research on the role cytokines and regulatory molecules may play in cross-cell communication

  • profiles commonly used vectors for somatic gene therapy, as well as the latest advances in genetic engineering and vector design and production

  • utilizes up-to-the-minute techniques such as fluorescence in-situ hybridization (FISH) and comparative genomic hybridization (CGH) to detect genetic abnormalities and aberrations

  • explores current measures of supportive care with splenectomy, cytokine proteins, and intravenous immunoglobulin applications

  • identifies how to manage infectious and psychiatric complications in patients with CLL

  • and much more!

    Provides contemporary results on the efficacy of nucleoside analog combinations such as ara-C with fludarabine and cladribine and on the emerging nucleosides nelarabine and clofarabine!

    Copiously supplemented with over 2500 literature references-1000 more than the first edition-Chronic Lymphoid Leukemias, Second Edition fulfills the reference needs of oncologists, hematologists, immunologists, pathologists, infectious disease specialists, internists, molecular biologists, and medical school students in these disciplines.

  • Reviews


    Praise for the first edition…

    An informative, up-to-date, well-referenced, and user-friendly text.

    With an illustrious cadre of authors, Cheson has crafted together state-of-the-art reviews…

    …a valuable addition to reference libraries…this compendium meets the need for an excellent reference text on CLL."-Hematologic Pathology

    "…[an] important book.

    …well written and edited….the editor deserves praise for…fostering a general sense of continuity."-The New England Journal of Medicine

    "…of great value to hematologists and oncologists….readers will learn a lot about the recent progress in CLL."-International Journal of Hematology

    "…a valuable contribution in bringing together disparate aspects of biology and clinical management of CLL….a useful compendium."-Australian Cancer Society

    "…should be ready by everyone taking care of pediatric patients with chronic lymphocytic leukemia (CLL)…up-to-date….an excellent, comprehensive review of the current treatment modalities….

    …the best review of CLL and related diseases currently available.

    "-Annals of Oncology

    Table of Contents

    History of Chronic Lymphocytic Leukemia

    Kanti R. Rai and Tarun Wasil

    Molecular Biology of Chronic Lymphocytic Leukemia

    Florencia Bullrich and Carlo M. Croce

    Chronic Lymphocytic Leukemia: Epidemiological, Familial, and Genetic Aspects

    Maria T. Sgambati, Martha S. Linet, and Susan S. Devesa

    The Origin and Nature of the Chronic Lymphocytic Leukemia Lymphocyte

    Paolo Ghia and Federico Caligaris-Cappio

    Immunoglobulin Variable Region Gene Characteristics and Surface Membrane Phenotype Define B-CLL Subgroups with Distinct Clinical Courses

    Nicholas Chiorazzi and Manlio Ferrarini

    Apoptosis Dysregulation in Chronic Lymphocytic Leukemia

    John C. Reed and Shinichi Kitada

    Cytokines and Regulatory Molecules in the Pathogenesis and Clinical Course of B-Cell Chronic Lymphocytic Leukemia

    Enrica Orsini and Robin Foa

    Randomized Trials: What Do They Teach us About Chronic Lymphocytic Leukemia Treatment?

    G. Dighiero

    Genetic Approaches to the Therapy of Chronic Lymphocytic Leukemia

    Thomas J. Kipps

    Combination Strategies for Purine Nucleoside Analogs

    Varsha Gandhi and William Plunkett

    Differential Diagnosis of the Chronic B-Cell Lymphoid Leukemias

    Randy D. Gascoyne

    Prognostic Factors in Chronic Lymphocytic Leukemia

    Stefano Molica

    Initial Approach to the Patient with Chronic Lymphocytic Leukemia

    Bruce D. Cheson

    Management of the Patient with Relapsed or Refractory Chronic Lymphocytic Leukemia

    Deborah A. Thomas, Susan M. O'Brien, and Michael J. Keating

    The Use of Therapeutic Monoclonal Antibodies in Chronic Lymphocytic Leukemia

    Martin J. S. Dyer and Anders Österborg

    Genomic Aberrations in B-Cell Chronic Lymphocytic Leukemia

    Stephan Stilgenbauer, Peter Lichter, and Hartmut Döhner

    Developing Risk-Adapted Treatment Strategies for Chronic Lymphocytic Leukemia

    Emilio Montserrat

    High-Dose Therapy and Stem Cell Support in Chronic Lymphocytic Leukemia

    Angela M. Krackhardt and John G. Gribben

    Finding New Therapies for Patients with Chronic Lymphocytic Leukemia

    John C. Byrd and Michael R. Grever

    Autoimmune Disease and Its Management in Chronic Lymphocytic Leukemia

    Terry Hamblin

    Richter's Syndrome

    John Seymour and Janine Campbell

    Supportive Care in Chronic Lymphocytic Leukemia

    Farhad Ravandi, Michael J. Keating, and Susan M. O'Brien

    Infections in Patients with Chronic Lymphocytic Leukemia: Pathogenesis, Spectrum, and Therapeutic Approaches

    Vicki A. Morrison

    Prolymphocytic Leukemia of B- and T-Cell Types: Biology and Therapy

    Estella Matutes, Vasantha Brito-Babapulle, Claire Dearden, M. R. Yullie, and Daniel Catovsky

    Chronic T-Cell and NK-Cell Leukemias

    Edgar G. Miranda and Thomas P. Loughran, Jr.

    Current Concepts in the Management of Hairy Cell Leukemia

    Martin S. Tallman, Mark A. Hoffman, and LoAnn C. Peterson

    Psychological Aspects of Chronic Lymphoid Leukemia

    Jahandar Saifollahi, Marjaneh Rouhani, Andrew J. Roth, and Jimmie C. Holland

    About the Series

    Basic and Clinical Oncology

    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    MEDICAL / Hematology