Chronic Obstructive Pulmonary Disease Exacerbations  book cover
1st Edition

Chronic Obstructive Pulmonary Disease Exacerbations

ISBN 9781138372450
Published September 10, 2018 by CRC Press
456 Pages 64 B/W Illustrations

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Book Description

Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.

Written by today’s top experts, Chronic Obstructive Pulmonary Disease Exacerbations:

  • is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-use
  • examines current and breakthrough pharmacologic and non-pharmacologic treatments
  • includes COPD-causing exacerbations such as viral and bacterial infections
  • discusses the negative environmental factors relating to COPD

Table of Contents


Definitions and severity of COPD exacerbations: Stephen Rennard and Nancy Kline Leidy

Epidemiology of COPD exacerbations: David Mannino

Differential diagnosis of COPD exacerbations: Peter Calverley


Symptom changes at exacerbations: Terry Seemungal

Airway pathology at exacerbations: Marina Saetta

Airway and systemic inflammatory markers at exacerbation: John Hurst

Physiological changes at exacerbations: Dennis O’Donnell and Chris Parker

Systemic consequences of COPD exacerbations: Emiel Wouters

Mechanisms of respiratory failure at exacerbation: Roberto Rodriguez Roisin

Role of respiratory viral infection at exacerbation: Wisia Wedzicha and Jennie Quint

Do airway bacteria cause COPD exacerbations: Sanjay Sethi

Interactions of airway pathogens and inflammatory processes: Alberto Papi

Role of co-morbidity at COPD exacerbations: Bill MacNee, John Maclay and David McAllister

Environmental causes of exacerbations: David Hui and Fanny Ko

Mechanisms and pathophysiological changes in alpha-1 AT deficiency exacerbations: Rob Stockley

Experimental models of COPD exacerbations: Jeff Curtis

Comparison of asthma and COPD exacerbations: Sebastian Johnston


Exacerbations and health status: Paul Jones

Risk factors for hospital admission: Judith Garcia Aymerich

Effect of exacerbations on disease progression and mortality: Gavin Donaldson

Health economic consequences of COPD exacerbations: Marc Miravitlles


Use of bronchodilators and mucolytics at COPD exacerbations: Marc Decramer

Corticosteroids in the management of acute exacerbations: Denis Niewoehner

Antibiotic therapy at COPD exacerbations: Rob Wilson

Non invasive ventilatory support: Mark Elliott and Stanley Miller

Invasive ventilation and weaning at COPD exacerbation: Antonio Anzueto

Oxygen therapy at exacerbations: Tony Davison and Luke Wilson

End of life issues and COPD exacerbations: Anita Simonds

Novel models of care for COPD exacerbations: Martyn Partridge

Physiotherapy airway clearance at exacerbation: Christine Mikelsons and Rachel Garrod

COPD exacerbation and pulmonary rehabilitation: Mike Polkey and William Mann


Pharmacological prevention of COPD exacerbations: Leo Fabbri

Early intervention and self-management in exacerbation prevention: Jean Bourbeau

Immunological interventions: Phillip Poole

Home mechanical ventilation and oxygen therapy: Gerry Criner and Nat Marchetti


Design of trials for COPD exacerbations: Fernando Martinez

Statistical considerations for COPD exacerbation trials: Shawn Aaron

Future development in COPD exacerbations: Peter Barnes

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JADWIGA A. WEDZICHA is Professor of Respiratory Medicine at the University College London and Honorary Consultant Physician, Royal Free Hospital NHS Trust, London, UK. She received her M.D. from the University of London, London, UK. Dr. Wedzicha has a major interest in the causes, mechanisms, and impact of COPD exacerbations and has published extensively on this topic. She also is an expert on home oxygen therapy and non-invasive ventilation in COPD patients. Dr. Wedzicha has chaired the British Thoracic Society (BTS) working group on home oxygen therapy, is currently chairing the BTS Home Oxygen Guidelines Group, and is a member of the Department of Health’s External Stakeholders Advisory Group for the Home Oxygen Service. She was a member of the Guideline Development Group for the NICE COPD guidelines and the External Reference Group (ERG) of the COPD National Service Framework (NSF). Dr. Wedzicha directs an active internationally recognized research group into aspects of COPD exacerbations with major grant funding. She is currently Editor-in-Chief of the respiratory journal Thorax, a member of the British Medical Journal advisory board, and an editorial board member for a number of international journals.

FERNANDO J. MARTINEZ is Medical Director of Pulmonary Diagnostic Services; Pulmonary Director of the Cough/Dyspnea Clinic; Associate Director of Bronchoscopy Service; Director of the Lung Volume Reduction Program; Professor of Pulmonary and Critical Care Medicine; and Co-Medical Director of the Lung Transplantation Program, the University of Michigan Health System, Ann Arbor, Michigan, USA. Dr. Martinez received his M.D. from the University of Florida School of Medicine, Gainesville, Florida, USA. From 2002 to the present, he has been named on both the national and Midwest "Best Doctors in America" lists, in addition to "Metro Detroit’s Best Doctors" list. Dr. Martinez is an active member of several professional organizations, including the American College of Chest Physicians, the American Thoracic Society, and the American Association of Cardiovascular and Pulmonary Rehabilitation. He is Associate Editor of the American Journal of Respiratory and Critical Care Medicine, and he serves on the editorial and review boards of several other journal publications. Dr. Martinez is an accomplished author/contributor and invited lecturer, and has received numerous grants to research respiratory health and disease.