Cleanroom Microbiology for the Non-Microbiologist: 2nd Edition (Hardback) book cover

Cleanroom Microbiology for the Non-Microbiologist

2nd Edition

By David M. Carlberg

CRC Press

216 pages | 60 B/W Illus.

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Hardback: 9780849319969
pub: 2004-10-28
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pub: 2004-10-28
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Description

Written for the professional who has an immediate need for the information but has little or no training in the subject, Cleanroom Microbiology for the Non-Microbiologist, Second Edition introduces principles of microbiology. It explains the consequences of microbiological contamination, what contamination is all about, how microorganisms grow, and how they can be controlled. The author introduces the vocabulary of microbiology and the types, sources, control, and elimination of organisms encountered in the manufacture of sterile products. Beginning with a discussion of the various types of organisms, the text then covers applications for bacterial detection, avoidance of contamination, cleanroom design considerations, and validation of disinfection methods.

New topics covered include:

  • International cleanroom standards

  • Application of rapid, automated methods for detecting and identifying microbial contaminants

  • In-depth examination of the role of biofilms in pure water systems

  • Increased coverage of production of therapeutic products derived from live tissues and cells
  • Table of Contents

    THE SCOPE OF MICROBIOLOGY

    Introduction

    Cells

    Binomial Nomenclature

    Morphology

    New! Specific Microbial Groups

    New! Taxonomy of Microorganisms

    Microscopy

    Summary

    References

    GROWTH OF MICROORGANISMS

    Introduction

    Growth of Bacteria

    New! Growing Other Microorganisms: Fungi, Protozoa, Algae and Viruses

    Aseptic Technique

    New! Safety Issues

    Summary

    References

    CONTROLLING GROWTH AND ACTIVITIES OF MICROORGANISMS

    Introduction

    New! Definitions

    Physical Methods of Control

    New! Assuring Sterility

    New! Chemical Methods of Control

    Control of Microorganisms in High Purity Water Systems

    Summary

    References

    FACILITIES AND PERSONNEL CONTROLS

    Introduction

    New! Certified Cleanrooms

    New! Bioclean Facilities- Viable vs. Non-Viable Particles

    Clean Facilities - General Considerations

    New! Unidirectional Air Flow

    New! HEPA and ULPA Filters

    New! Aseptic Fill Areas

    New! Barriers, Clean Zones and Isolators

    New! Biosafety Levels

    Cleanroom Garments

    New! Personnel Practices and Training

    New! Personal Hygiene

    General Personnel Practices

    Summary

    References

    DETECTION AND ENUMERATION OF MICROORGANISMS IN THE CLEANROOM

    Introduction

    New! Overview of Microbiological Environmental Monitoring

    New! Monitoring of Air

    Fallout Methods

    Surface Monitoring

    New! Touch Plates and Other Personnel Monitoring

    Microbiological Assessment of Liquids

    Microbiological Assessment of Solids and Semisolids

    New! Monitoring for Specific Microorganisms

    New! Rapid Methods of Identification

    New! Testing for Bacteriostasis and Fungistasis

    New! Detection of Biofilms

    Sterile Media Fill Tests

    Alert and Action Levels

    New! The Sterility Suite

    Disposal of Cultures

    Summary

    References

    Subject Categories

    BISAC Subject Codes/Headings:
    MED071000
    MEDICAL / Pharmacology
    SCI045000
    SCIENCE / Life Sciences / Biology / Microbiology