This book presents a state-of-the-art summary of the applications of low temperature to clinical situations, together with details of the underlying principles of biology. It provides specific information for the clinicians and research workers in a number of areas of current interest and attempts to provide a unifying theme of cryobiology of interest and value to those researching a clinical problem. Specific topics discussed include the effects of low temperatures on mammalian systems in the absence of ice and how the changes can be modulated to achieve desired results; low temperature storage of tissues and organs for transplantation in the liquid state; the effects of whole body hypothermia in man and how it relates to mammal hibernation; problems associated with ice formation and the subsequent freezing of cells and tissues; cryopreservation of blood cells, reproductive cells, and tissues, such as the skin and cornea. Other interesting issues featured include the developments in cryopreservation of large, highly-organized structures and the destructive powers of ice formation in cryosurgery of diseased tissues.
The Effects of Cooling on Mammalian Cells (B.J. Fuller). Survival and Rescucitation from Hypothermia: What Natural Hibernation Can Teach Us About the Mammalian Response to Hypothermia (M.L. Jourdan, T.F. Lee and L.C.H. Wang). Hypothermia and Preservation of Organs in the Liquid State (W. De Loecker). Biological Effects of the Water/Ice Transition (B.W.W. Grout). Low Temperature Storage of Blood Cells and Stem Cells (C. Korber and A. Sputak). Low Temperature Preservation and Storage of Reproductive Cells (A. Bernard). Tissue Storage at Low Temperatures (J. Armitage). Organ Cryopreservation (A. Karow). Cryosurgery and Cryoanalgesia (C. Green). c. 256 pp., 7x10, due September 1991, ISBN 0-8493-5429-3.