1st Edition

Clinical Applications of Magnetic Nanoparticles From Fabrication to Clinical Applications

Edited By Nguyen TK Thanh Copyright 2018
    516 Pages 287 Color & 71 B/W Illustrations
    by CRC Press

    516 Pages 287 Color & 71 B/W Illustrations
    by CRC Press

    516 Pages 287 Color & 71 B/W Illustrations
    by CRC Press

    Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.

    Section I Fabrication, Characterisation of MNPs

    Chapter 1 Controlling the Size and Shape of Uniform Magnetic Iron Oxide Nanoparticles for Biomedical Applications

    [Helena Gavilán, Maria Eugênia Fortes Brollo, Lucía Gutiérrez, Sabino Veintemillas-Verdaguer

    and María del Puerto Morales]

    Chapter 2 Magnetic Nanochains: Properties, Syntheses and Prospects

    [Irena Markovic-Milosevic, Vincent Russier, Marie-Louise Saboungi and Laurence Motte]

    Chapter 3 Carbon-Coated Magnetic Metal Nanoparticles for Clinical Applications

    [Martin Zeltner and Robert N. Grass]

    Chapter 4 Bioinspired Magnetic Nanoparticles for Biomedical Applications

    [Changqian Cao and Yongxin Pan]

    Section II Biofunctionalisation of MNPs

    Chapter 5 Main Challenges about Surface Biofunctionalization for the In Vivo Targeting of Magnetic Nanoparticles

    [Laurent Adumeau, Marie-Hélène Delville and Stéphane Mornet]

    Chapter 6 Experimental Considerations for Scalable Magnetic Nanoparticle Synthesis and Surface Functionalization

    for Clinical Applications

    [Alec P. LaGrow, Maximilian O. Besenhard, Roxanne Hachani and Nguyễn Thị Kim Thanh]

    Chapter 7 Magnetic Polymersomes for MRI and Theranostic Applications

    [Adeline Hannecart, Dimitri Stanicki, Luce Vander Elst, Robert N. Muller and Sophie Laurent]

    Chapter 8 Ultrasmall Iron Oxide Nanoparticles Stabilized with Multidentate Polymers for Applications in MRI

    [Jung Kwon (John) Oh and Marc-André Fortin]

    Chapter 9 Encapsulation and Release of Drugs from Magnetic Silica Nanocomposites

    [Damien Mertz and Sylvie Bégin-Colin]

    Section III In-Vitro Application of MNPs

    Chapter 10 Current Progress in Magnetic Separation-Aided Biomedical Diagnosis Technology

    [Sim Siong Leong, Swee Pin Yeap, Siew Chun Low, Rohimah Mohamud and JitKang Lim]

    Chapter 11 Magnetic Separation in Integrated Micro-Analytical Systems

    [Kazunori Hoshino]

    Chapter 12 Magnetic Nanoparticles for Organelle Separation

    [Mari Takahashi and Shinya Maenosono]

    Chapter 13 Magnetic Nanoparticle-Based Biosensing

    [Kai Wu, Diqing Su, Yinglong Feng and Jian-Ping Wang]

    Section IV In-Vivo Application of MNPs

    Chapter 14 Immunotoxicity and Safety Considerations for Iron Oxide Nanoparticles

    [Gary Hannon, Melissa Anne Tutty and Adriele Prina-Mello]

    Chapter 15 Impact of Core and Functionalized Magnetic Nanoparticles on Human Health

    [Bella B. Manshian, Uwe Himmelreich and Stefaan J. Soenen]

    Chapter 16 Magnetic Nanoparticles for Cancer Treatment Using Magnetic Hyperthermia

    [Laura Asín, Grazyna Stepien, María Moros, Raluca Maria Fratila and Jesús Martínez de la Fuente]

    Chapter 17 Nanoparticles for Nanorobotic Agents Dedicated to Cancer Therapy

    [Mahmood Mohammadi, Charles Tremblay, Ning Li, Kévin Gagné, Maxime Latulippe,

    Maryam S. Tabatabaei and Sylvain Martel]

    Chapter 18 Smart Nanoparticles and the Effects in Magnetic Hyperthermia In Vivo

    [Ingrid Hilger]

    Chapter 19 Noninvasive Guidance Scheme of Magnetic Nanoparticles for Drug Delivery in Alzheimer’s Disease

    [Ali Kafash Hoshiar, Tuan-Anh Le, Faiz Ul Amin, Xingming Zhang, Myeong Ok Kim and Jungwon Yoon]

    Chapter 20 Design, Fabrication and Characterization of Magnetic Porous PDMS as an On-Demand Drug

    Delivery Device

    [Ali Shademani, Hongbin Zhang and Mu Chiao]

    Chapter 21 Magnetic Particle Transport in Complex Media

    [Lamar O. Mair, Aleksandar N. Nacev, Sagar Chowdhury, Pavel Stepanov, Ryan Hilaman, Sahar Jafari,

    Benjamin Shapiro and Irving N. Weinberg]

    Chapter 22 Magnetic Nanoparticles for Neural Engineering

    [Gerardo F. Goya and Vittoria Raffa]

    Chapter 23 Radionuclide Labeling and Imaging of Magnetic Nanoparticles

    [Benjamin P. Burke, Christopher Cawthorne and Stephen J. Archibald]

    Chapter 24 Red Blood Cells Constructs to Prolong the Life Span of Iron-Based Magnetic Resonance

    Imaging/Magnetic Particle Imaging Contrast Agents In Vivo

    [Antonella Antonelli and Mauro Magnani]

    Chapter 25 Stimuli-Regulated Cancer Theranostics Based on Magnetic Nanoparticles

    [Yanmin Ju, Shiyan Tong and Yanglong Hou]

    Section V Good Manufacturing Practice

    Chapter 26 Good Manufacturing Practices (GMP) of Magnetic Nanoparticles

    [Nazende Günday Türeli and Akif Emre Türeli]


    Professor Nguyen TK Thanh, FRSC, MInstP (http://www.ntk-thanh.co.uk) held a prestigious Royal Society University Research Fellowship (2005-2014). She was appointed a Full Professor in Nanomaterials in 2013 at Biophysics Group, Department of Physics and Astronomy, University College London, UK. She leads a very dynamic group conducting cutting edge interdisciplinary and innovative research on the design, and synthesis of magnetic and plasmonic nanomaterials for biomedical applications. A very strong feature of her research program is the development of new chemical methods and in collaboration with chemical engineers to produce the next generation of nanoparticles with very high magnetic moment, and novel hybrid and multifunctional nanostructures. Detailed mechanistic studies of their formation by sophisticated and advanced analysis of the nanostructure allows tuning of the physical properties at the nanoscale; these can subsequently be exploited for diagnosis and treatment of various diseases. The studies are conducted to provide insight for future material design approaches. It will also help to identify the critical process parameters that can be manipulated in order to obtain the suitable physical properties for the intended applications.

    She was the sole editor of the book: "MAGNETIC NANOPARTICLES: FROM FABRICATION TO CLINICAL APPLICATIONS" published by CRC Press/Taylor and Francis: http://www.crcpress.com/product/isbn/9781439869321. In 2016, she was a Guest Editor of The Royal Society Interface Focus on "Multifunctional nanostructures for diagnosis and therapy of diseases".

    She has published over 80 peer reviewed journal articles and book chapters with over 4000 citations so far. She has been Visiting Professors at various Universities in France, Japan, China and Singapore. She has been an invited speaker at nearly 200 institutes and scientific meetings. She has a leadership role in professional communities by chairing and organising 30 high profile international conferences such as American Chemistry Society symposia in 2018, 2012, 2010; Royal Society of Chemistry UK Colloids Conferences in 2017, 2014, 2011; European Material Research Society Symposia in 2016, 2013; ICMAT Singapore in 2015, 2013; Faraday Discussions in 2014 and being a member of advisory boards in Europe, USA and Japan. She served in Joint Committee of the Royal Society of Chemistry Colloid & Interface Science Group and the Society of Chemical Industry Colloid & Surface Chemistry Group (2008-2017). She is an elected member of The Royal Society of Chemistry Faraday Division Council and currently serving in Awards Committee and was a representative member of Joint Colloids Groups (2013-2016). She is a workgroup leader of EU COST Action TD1402 on Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy (RADIOMAG). She is a Co-chair of the 13th International Conference on the Scientific and Clinical Applications of Magnetic Carriers in June 2020, London, UK.