The third edition of this successful textbook has been completely updated throughout and includes new chapters on electrophysiological tests, biological markers, global staging measures, and management of neuropsychiatric symptoms. There has been steady progress in our understanding of the natural history, prognostic factors and treatments for Alzheimer’s disease since the previous edition of this textbook was published in 1999. The chapters deal with the full spectrum of populations at risk, persons in prodromal stages, and patients from mild to severe and even terminal stages. The contributors are opinion leaders from North America and Europe, which gives the book an internationally balanced outlook. This new edition will be essential reading for a wide range of clinical neuroscientists who manage patients with this challenging disease.
Section I: Introduction to the Disease Process 1. Definitions and Diagnostic Criteria 2. Pathophysiology: A Neurochemical Perspective 3. Pathophysiology: An Epidemiological Perspective Section II: Diagnosis 4. Typical Clinical Features 5. Differentiation from Non-Alzheimer Dementias 6. Neuropsychological Assessment 7. Structural Brain Imaging 8. Functional Brain Imaging 9. Electrophysiological Tests 10. Biological Markers Section III: Natural Evolution 11. Natural Decline and Prognostic Factors 12. Global Assessment Measures 13. Depressive Syndrome in Alzheimer’s Disease 14. Cognition 15. Functional Automony 16. Behaviour Section IV: Medical Management 17. Mild Cognitive Impairment and Very Early Stage Alzheimer’s Disease 18. Mild to Moderate Stages 19. Care of Patients in Severe Stage of Dementia 20. Terminal Stage 21. Co-existent Medicial Problems and Concomitant Diseases 22. Management of Neuropsychiatric Symptoms Section V: Community and Institutional Management 23. Caregiver Support 24. Community-based Formal Support Services Section VI: Ethical and Quality of Life: Issues 25. Ethical Issues 26. Competency 27. Genetic Counselling 28. Health-related Quality of Life Measurement Techniques in the Manage,ent of Dementia Section VII: Conclusions 29. Future Diagnosis and Management of Alzheimer’s Disease