Clinical Neurovirology: 2nd Edition (Hardback) book cover

Clinical Neurovirology

2nd Edition

Edited by Avindra Nath, Joseph R. Berger

CRC Press

520 pages | 31 Color Illus. | 63 B/W Illus.

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Hardback: 9781498733168
pub: 2020-05-14
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This is a comprehensive reference that includes the basic science, clinical features, imaging, pathology and treatment of specific viral entities affecting the central nervous system (CNS). It will assist professionals in their attempt to identify, examine and manage viral CNS infections and unravel the therapeutic and diagnostic challenges associated with viral CNS disorders.

Key Features

  • Features MRI scans, histopathology and lined diagrams showing pathophysiology
  • Much has happened in our understanding of CNS infections in recent years and a comprehensive book that covers the entire subject is much needed.
  • There is ongoing interest in infectious disease. The increasing globalization of medicine is putting demands on many more people to become familiar with issues from around that world that they did not see in training.

Table of Contents



Part I: Introduction: Epidemiology socioeconomic impact, challenges ahead

  1. Introduction to Virus Structure, Classification, Replication, and Hosts
  2. Philippe Simon and Kevin M. Coombs

  3. Neuropathogenesis Of Viral Infections
  4. Avindra Nath, Joseph R. Berger

  5. An Approach to Pathogen Discovery for Viral Infections of the Nervous System

    Prashanth S. Ramachandran, Michael R. Wilson

  7. Neuropathology of CNS Viral Infections and The Role of Brain Biopsy in the Diagnosis

    Susan Morgello

    Part II: DNA Viruses

  9. Herpes Simplex Viruses: Cause of Disease and Promising Therapeutic Vehicles

    Israel Steiner, Felix Benninger

  11. Varicella Zoster Virus Infection

    Don Gilden, Randall J. Cohrs, Dallas Jones, Maria A. Nagel

  13. Epstein-Barr Virus and the Nervous System
  14. Alexandros Tselis, Kumar Rajamani & Pratik Bhattacharya.

  15. Cytomegalovirus

    Joseph R. Berger

  17. Progressive Multifocal Leukoencephalopathy
  18. Eric ML Williamson and Joseph R Berger

  19. Adenovirus
  20. Jennifer McGuire and Joseph R Berger


    Part III: Retroviruses

  21. HIV Neurological Complications

    Alessandro Fois and Bruce Brew

  23. Human T Lymphotropic Virus Type 1 (HTLV-1)
  24. Shila Azodi and Steven Jacobson

    Part IV: RNA Viruses

  25. Rabies and other lyssaviruses
  26. Thiravat Hemachudha, Jiraporn Laothamatas and Henry Wilde

    Anthropod-Borne Virus Encephalitis

  27. Neurological Manifestations of West Nile Virus
  28. Daniel E. Smith, J. David Beckham, Daniel M. Pastula and Kenneth L. Tyler

  29. Chikungunya Virus and Japanese Encephalitis Virus
  30. Jennifer L. Lyons

  31. Arthropod-Borne Virus Encephalitis
  32. Joseph R Berger

  33. Enteroviruses
  34. Karen Straube-West and Burk Jubelt

  35. Measles and its neurological complications
  36. Benedikt Weissbrich and Jürgen Schneider-Schaulies

  37. Rubella
  38. Avindra Nath

  39. Influenza neurologic complications
  40. Larry E. Davis and Jennifer R. Plourde

  41. Nipah Encephalitis, a fatal encephalitis with bats as reservoir
  42. Chong-Tin Tan and Kum-Thong Wong



    Part V: Miscellaneous

  43. Von Economo’s Encephalitis
  44. Joseph R. Berger

  45. Neurologic Events Following Immunizations
  46. James J. Sejvar

  47. Central Nervous System Viral Infections Complicating Immunosuppression
  48. Amy A. Pruitt

  49. Post-Viral Syndromes
  50. Anusha K. Yeshokumar, Eliza Gordon-Lipkin, Brenda Banwell

  51. Viral Neuro-oncogenesis: Polyomaviruses and Brain Tumors
  52. Martyn K. White, Sidney E. Croul and Kamel Khalili

  53. Autoimmune disorders that can be mistaken for viral illness
  54. Maxwell Greene and Eric Lancaster

  55. Antiviral Therapeutics for Viral Infections of the Central Nervous System

Richard Whitley

About the Editors

Avindra Nath

Dr. Nath is the Chief of the Section of Infections of the Nervous System at the National Institute of Neurological Disorders and Stroke. He was previously Professor in the Department of Neurology and Director of the Division of Neuroimmunology and Neurological Infections at Johns Hopkins University. His career has been dedicated to studying the clinical manifestations, pathophysiology and developing treatment for brain infections since the beginning of the AIDS pandemic. He has traveled to several countries to study these infections including Liberia during the Ebola epidemic. He teaches medical students, residents and clinical fellows on CNS infections for which he has received several teaching awards. He frequently talks at grand rounds, seminars and conferences around the world on viral infections of the brain and has been teaching courses on viral encephalitis at the American Academy of Neurology for over 20 years. His laboratory research is focused mainly on retroviral infections particularly HIV infection. More recently, his laboratory is studying the pathophysiology of Ebola and Zika viruses. He is the past President of the International Society of Neurovirology (ISNV) and an elected member of the Association of American Physicians. He is the recipient of the Pioneer award from the ISNV and the Wybran award from the Society of Neuroimmune Pharmacology.

Joseph R. Berger

Dr. Berger, M.D., is Professor of Neurology and Associate Chief of the Multiple Sclerosis Division of the Department of Neurology at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia. His career has been dedicated to the diagnosis, treatment and investigation of neuroinfectious and neuroinflammatory disorders. His foray into neuroinfectious diseases started with the investigation of the neurological complications of HIV/AIDS while at the University of Miami at the inception of the AIDS pandemic and an endowment there established the Whigham-Berger Endowed Chair, the first endowed chair for the study of the neurological complications of HIV/AIDS. Dr. Berger continued his research in HIV and PML while at the University of Kentucky where he was Chairman of the Department of Neurology from 1995 to 2013. With Dr. Robert Levy, he co-founded and co-chaired the international Neuroscience of HIV conference. He is a fellow of the American College of Physicians, American Academy of Neurology and the American Neurological Association. Among his many awards are the Pioneer Award from the International Society of Neurovirology and the Distinguished Teaching Award from the American Neurological Association.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Infectious Diseases
MEDICAL / Neurology
SCIENCE / Life Sciences / Neuroscience