Clinical Potential of Exosomes Diagnostic and Therapeutic Insights

Preface

1. Overview of Extracellular Vesicles

Pankti C. Balar, Vladimir N. Uversky, Jimil Gandhi, Karishma Prajapati, and Vivek P. Chavda

2. Genesis of Extracellular Vesicles: Insight to a Complex Ecosystem

Devesh U. Kapoor, Mona R. Kukkar, Mansi Gaur, Vineet Jain, Sudarshan Singh, and Rupesh K. Gautam

3. Isolation and Purification of Extracellular Vesicles

Salwal and Lalit Kumar

4. Engineered and Surface Modified Exosomes: Site-Specific Drug Delivery

Bedanta Bhattacharjee, Sandhanam K., Rajashri Bezbaruah, Ram Kumar Sahu, Niva Rani Gogoi, Tamilanban T., Damanbhalang Rynjah, Gamal Osman Elhassan, Dhunusmita Barman, and Vivek P. Chavda

5. Drug Loading in Exosomes

Pankti C. Balar, Vasso Apostolopoulos, Keval Prajapati, Zahabiya Vaghjipurwala, and Vivek P. Chavda

6. Exosomes and Other Extracellular Vesicles: Process, Design, and Characterization

Chandni Vora, Dharmista Agrawal, Pankti C. Balar, Dixa A. Vaghela, Lalitkumar Vora, and Vivek P. Chavda

7. Characterization of Exosome and Other Extracellular Vesicles

Divya Teli, Rudri Khatri, Riyansi Satasia, Vishwa Patel, Dhvani Gala, and Vivek P. Chavda

8. Exosomes and Other Extracellular Vesicles for Diagnostics

Shailvi Soni, Amit Z Chaudhary, Terrick Andey, and Vivek P. Chavda

9. Exosomes and Other Extracellular Vesicles for Cancer Management

Mit Joshi, Disha Shah, Vivek P. Chavda, and Bhoomika M. Patel

10. Exosomes and Other Extracellular Vesicles for Cardiovascular Diseases

Niva Rani Gogoi, Alan Raj, Venessa Nath, Rajashri Bezbaruah, Ranjit Kumar Mahato, Angel Treasa Alex, Bhaskar Mazumder, and Vivek P. Chavda

11. Exosomes and Other Extracellular Vesicles for Neurodegenerative Diseases

Rajashri Bezbaruah, Sheikh Rezzak Ali, Farak Ali, Md. Ariful Islam, Shahnaz Alom, Rubina Chowdhury, and Vivek P. Chavda

12. Exosomes and Other Extracellular Vesicles for Infectious Diseases

Kajal P. Baviskar, Shilpa S. Raut, Komal P. Mahajan, Anjali P. Bedse, A. R. Surana, Pankti C. Balar, and Vivek P. Chavda

13. Exosomes and Other Extracellular Vesicles for Reproductive Medicines

Shruti Soni, Aayushi C. Shah, and Vivek P. Chavda

14. Exosomes and Other Extracellular Vesicles for Dermal Ailments

Vivek P. Chavda, Dixa A. Vaghela, B. H. Jaswanth Gowda, Payal P. Dodiya, Achmad Himawan, and Lalitkumar K. Vora

15. Theranostic Applications of Exosomes and Other Extracellular Vesicles

Avinash Khadela, Humzah Postwala, Neha Raghani, Mohammad Kaif A. Mansuri, Yesha Shah, and Vivek P. Chavda

16. Exosomes and Other Extracellular Vesicles-Based Vaccine Delivery

Amol D. Gholap, Pankaj R. Khuspe, Vivek Hala, Vasso Apostolopoulos, and Vivek P. Chavda

17. Exosomes and Other Extracellular Vesicles in Regenerative Medicines

Srivatsa Surya Vasudevan, Tiba Yamin Kandrikar, N. L. Swathi, Muhammad Bilal Shabbir, Neel Vora, Aisha Shabbir, Shaghaf Zahoor, Debankur Dey, Sumana Kundu, Piyush Gondaliya, and Vivek P. Chavda

18. Exosomes and Other Extracellular Vesicles in Gene Therapy and Personalized Care

Geeta Mahalawat, Tarun Virmani, Girish Kumar, Ashwani Sharma, Prachi Saini, Kanika Mangla, and Kamla Pathak

19. Role of Bioinformatics, AI, and ML for Exosomes and Other Extracellular Vesicle-Based Drug Products

Keshava Jetha, Disha Joshi, Mangesh Kulkarni, Usha Desai, and Vivek P. Chavda

20. Regulatory Aspects and Concerns Regarding Exosome-Based Drug Delivery

Aprameya Ganesh Prasad and Vivek P. Chavda

21. Exosomes and Other Extracellular Vesicles for Ophthalmic Ailments

Dixa A. Vaghela, B. H. Jaswanth Gowda, Lalitkumar K. Vora, Thakur Raghu Raj Singh, Hetvi Jani, Devanshi Gohel, and Vivek P. Chavda

Biography

Vivek P. Chavda, MPharm, is an Assistant Professor in the Department of Pharmaceutics and Pharmaceutical Technology at the L. M. College of Pharmacy, India. Before joining academia, he served in the biologics industry for almost eight years in research and development with two successful regulatory filings at Lupin Biotech (Pune) and Dr. Reddy's Laboratory (Hyderabad). He has to his credit more than 250 national and international publications, including book chapters, books, as well as numerous newsletter articles. He also has seven patents in progress. His research interests include development of biologics processes and formulations, medical device development, nano-diagnostics, long-acting parenteral formulations, and nano-vaccines. He has been listed among the World's Top 2% Scientists by Stanford University, USA, for 2023 and 2024.

“Explores one such marvel of nature: exosomes . . .  This book is a testament to the collaborative efforts of researchers, clinicians, and innovators who have dedicated their lives to unravelling the mysteries of exosomes. It serves as a beacon of knowledge, illuminating the path forward for scientists, physicians, and students who seek to harness the incredible potential of these tiny vesicles for the betterment of human health.”

—From the Foreword by Vasso Apostolopoulos, Professor Immunology, Institute for Health and Sport, Victoria University, Melbourne, Australia