Clinical Tuberculosis  book cover
6th Edition

Clinical Tuberculosis

ISBN 9780367529963
Published April 29, 2022 by CRC Press
468 Pages 33 Color & 117 B/W Illustrations

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Book Description

Entirely updated and revised, the 6th edition of Clinical Tuberculosis continues to provide the TB physician with a definitive and erudite account of the latest techniques in diagnosis, treatment and control of TB, including an overview of the latest guidelines from the CDC and WHO. With an increased emphasis on the clinical aspects and treatment, this book will be an invaluable resource to the TB practitioner in public health or clinical practice and an ideal reference to laboratory staff.

Key Features

  • Completely updated and reorganized
  • Includes brand new chapters on radiology and an overview of the latest WHO, ATS/CDC/IDSA, ERS, NICE, CTS and IUATLD guidelines
  • Clinically focused to provide up-to-date guidance on diagnosis, treatment and control
  • Edited by three renowned experts in the field of tuberculosis

Table of Contents






1. The History of Tuberculosis from Earliest Times to the Development of Drugs

Charlotte A. Roberts and Jane E. Buikstra

2. Epidemiology

Grant Theron, Ted Cohen, and Christopher Dye


3. Mycobacterium tuberculosis: The Genetic Organism

William R. Jacobs, Jr.

4. Pathogenesis of Tuberculosis

Divya B. Reddy and Jerrold J. Ellner


5. Using Genotyping and Molecular Surveillance to Investigate Tuberculosis Transmission

Sarah Talarico, Laura F. Anderson, and Benjamin J. Silk

6. Tuberculosis Transmission Control

Edward A. Nardell


7. Diagnosis of Active Pulmonary Tuberculosis

J. Lucian Davis

8. Radiology of Mycobacterial Disease

Anne McB. Curtis

9. Diagnosis of Latent TB Infection

Ajit Lalvani, Clementine Fraser, and Manish Pareek


10. Clinical Pharmacology of the Anti-Tuberculosis Drugs

Gerry Davies and Charles Peloquin

11. New Developments in Drug Treatment

Alexander S. Pym, Camus Nimmo, and James Millard

12. BCG and Other Vaccines

Rachel Tanner and Helen McShane


13. Pulmonary Tuberculosis

Charles S. Dela Cruz, Barbara Seaworth, and Graham Bothamley

14. Extrapulmonary Tuberculosis

Charles L. Daley

15. Tuberculosis and Human Immunodeficiency Virus Coinfection

Charisse Mandimika and Gerald Friedland

16. Drug-Resistant Tuberculosis

Keertan Dheda, Aliasgar Esmail, Anzaan Dippenaar, Robin Warren, Jennifer Furin, and Christoph Lange

17. The Surgical Management of Tuberculosis and Its Complications

Richard S. Steyn

18. Tuberculosis in Childhood and Pregnancy

Lindsay H. Cameron and Jeffrey R. Starke

19. Treatment of Latent Tuberculosis Infection Including Risk Factors for the Development of Tuberculosis

Martin Dedicoat


20. Treatment Guidelines for Active Drug-Susceptible and Drug-Resistant Pulmonary Tuberculosis, and Latent Tuberculosis Infection

Lynn E. Sosa and Lloyd N. Friedman


21. Tuberculosis Epidemic Control: A Comprehensive Strategy to Drive Down Tuberculosis

Salmaan Keshavjee, Tom Nicholson, Aamir J. Khan, Lucica Ditiu, Paul E. Farmer, and Mercedes C. Becerra


22. Animal Tuberculosis

Catherine Wilson


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Lloyd N. Friedman, M.D., is a Clinical Professor of Pulmonary, Critical Care and Sleep Medicine at the Yale School of Medicine, New Haven, CT. He is Director of Inpatient Quality and Safety for the Department of Internal Medicine. He is a member of the American Thoracic Society, a member of the Society of Critical Care Medicine, a fellow of the American College of Chest Physicians and a member of the International Union Against Tuberculosis and Lung Disease. He is Chairman of the Connecticut Tuberculosis Elimination Advisory Committee.

Martin Dedicoat PhD, FRCP, BSc, DTM&H is a Consultant physician in infectious diseases at the University Hospitals Birmingham. He is currently clinical lead for tuberculosis for Birmingham and Solihull, UK. His main research interests center around tuberculosis transmission in urban settings. Dr Dedicoat is a member of the British Thoracic Society drug resistant tuberculosis management group advising on management of complex tuberculosis patients across the UK. He also sits on the National Tuberculosis board for England.

Dr. Peter D. O. Davies graduated in 1966 from Marlborough College, Wilts, UK and obtained his BM, BCh and MA from University College, Oxford, UK in 1971 and St. Thomas’s Hospital in London in 1973. He gained a DM from oxford in 1984. He was a Consultant General and Respiratory Physician at Aintree University Hospital from 1988 to 2011 and at Liverpool Heart Chest Hospital from 1988 to 2015. He is or has been a member of the British Medical Association, the British Thoracic Society, the European Respiratory Society, the Royal College of Physicians of London (Fellow), the Royal Society of Medicine, the American Thoracic Society, the North Western Society of Respiratory Physicians where he served as President in 2007, the International Union Against Tuberculosis and Lung Disease where he was Chair of the Tuberculosis Section, President of the European section, and Editor in Chief of the International Journal of Tuberculosis and Lung Disease, and a member of NICE where he was chair of the Tuberculosis Section. He co-founded the UK Based TB charity in 1998. Dr. Davies is an expert in tuberculosis and edited the inaugural edition of the textbook, Clinical Tuberculosis in 1994 and has continued as editor for the subsequent 5 editions.


This sixth edition encompasses multiple aspects of Mycobacterium tuberculosis infection. Anyone actively involved in controlling tuberculosis should consider this book as a reference. It is suited to healthcare providers in both clinical and public health settings, especially if involved in tuberculosis eradication programs where complex situations arise with certain frequency. The editors and contributing authors are experts in the subject. The organization is logical for any infectious disease book, and the book strikes a good balance between depth and breadth. It is more accessible as a guideline for providers engaged in treating patients with tuberculosis or public health officers involved in eradication efforts.

Carlos E Figueroa Castro, MD(Medical College of Wisconsin)