Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
"International Praise for the First Edition. . . . . .a very useful resource book. . .The best chapters are full of insights that will continue to be useful for years to come. "
---The Quarterly Review of Biology
". . .provide[s] a useful perspective in what is a rapidly moving field. "
---Trends in Biochemical Science
". . .a remarkable book. . . . . .strongly recommend[ed]. . .It is up to date and contains information and references which everyone working in any aspect of bone marrow biology should have at hand. "
". . .an excellent compilation of modern knowledge concerning hematopoiesis and the colony-stimulating factors taken from a basic science to a clinical perspective. "
---American Journal of Physiology
". . .an excellent coverage of the field. "
". . .an exciting volume. "
Overview: introduction to the haematopoietic system; surrogate assays for haematopoietic stem cell activity; receptors for haematopoietic regulators; regulation of the cell cycle by kinases and cyclins; gene organization and regulation; cytokines and apoptosis - the mechanism of regulation of cell death; haematopoietic microenvironments; extracellular matrix- and membrane-bound cytokines; transfection of stem cells and gene therapy. Colony-stimulating factor: granulocyte-macrophage colony-stimulating factor and its receptor; granulocyte colony-stimulating factor; human interleukin-3 - an overview; macrophage colony-stimulating factor; erythropoietic; the role of interleukin-4 in normal and malignant human haematopoietic effects of interleukin-1; kit-ligand-stem cell factor; interleukin-5. Cytokines: macrophages inflammatory protein-1 alpha; transforming growth factor-beta, tumour necrosis factor-alpha, and macrophage inflammatory protein-1 alpha are bidirectional regulators of haematopoietic cell growth; leukaemia inhibitory factor; interleukin-12 in haematopoiesis; ex vivo expansion of haematopoietic stem and progenitor cells; clinical use of cytokines.