2nd Edition
Combinatorial Chemistry and Technologies Methods and Applications, Second Edition
Preface
Editors
Contributors
Combinatorial Chemistry and Combinatorial Technologies: Principles and Applications
Giorgio Fassina and Stanislav Miertus
Combinatorial Chemistry: From Split-Mix to Discrete
A´rpa´d Furka
Glycopeptide Libraries
Daniela Palomba and Giorgio Fassina
Design of Protease Inhibitors by Computer-Assisted Combinatorial Chemistry
Vladimir Frecer, Enrico Burello and Stanislav Miertus
Solid-Phase Synthesis of Organic Libraries
Eduard R. Felder and Daniela G. Berta
Resins, Linkers and Reactions for Solid-Phase Synthesis of Organic Libraries
Eduard R. Felder and Daniela G. Berta
Solution Phase Combinatorial Libraries of Small Organic Molecules
Rafael Ferritto, Elisabetta de Magistris, Andrea Missio, Alfredo Paio and Pierfausto Seneci
Direct Deconvolution Techniques for Pool Libraries of Small Organic Molecules
Pierfausto Seneci
Chapter 9 Encoding Techniques for Pool Libraries of Small Organic Molecules
Pierfausto Seneci
Chapter 10 Analytical Characterization of Synthetic Organic Libraries
Nikolai Sepetov and Olga Issakova
Key Ingredients for Efficient High-Throughput Screening
Lucia Carrano and Stefano Donadio
NMR in Combinatorial Chemistry
Edith S. Monteagudo and Daniel O. Cicero
Automation in Combinatorial Chemistry
Valery V. Antonenko
Computational Aspects of Combinatorial Chemistry
Valerie J. Gillet
High Throughput Combinatorial Methods for Heterogeneous Catalysts Design and Development
J.M. Domı´nguez
Biological Libraries
Maria Dani
Peptide Display Libraries: Design and Construction
Maria Dani
Making and Selecting from Phage Antibody Libraries
Andrew Bradbury, Daniele Sblattero, Hennie R. Hoogenboom and Simon Hufton
Biopanning
Giovanna Palombo
Globular Oligonucleotide Screening via the SELEX Process: Aptamers as High-Affinity, High-Specificity Compounds for Drug Development and Proteomic Diagnostics
Larry Gold
Applications of RNA and DNA Aptamers in Basic Science, Diagnostics and Therapy
Henning Ulrich
Combinatorial Proteomic
Maria Marino, Luca Beneduce, Daniela Palomba, Antonio Fiordelisi and Giorgio Fassina
A Combinatorial Approach to Gene Expression Analysis: DNA Microarrays
Concetta Ambrosino, Luigi Cicatiello, Claudio Scafoglio, Lucia Altucci and Alessandro Weisz
Economics of Combinatorial Chemistry and Combinatorial Technologies
Aris Persidis
Index
Biography
Stanislav Miertus, Giorgio Fassina
"The authors have been quite successful in their efforts to provide a guide to scientists involved in the field of drug discovery with little-or-no knowledge of combinatorial chemistry…this overall instruction guide is a valuable companion to scientists involved in combinatorial work. …The authors have succeeded in their endeavor by appraising several production methods, and comparing the costs for generating an entity through various research and development techniques."
-Yesh P. Sachdeva, Synthesis, 2006
