1st Edition
Combinatorial Synthesis of Natural Product-Based Libraries
Edited By Armen M. Boldi
Copyright 2006
362 Pages
247 B/W Illustrations
by
CRC Press
362 Pages
247 B/W Illustrations
by
CRC Press
368 Pages
by
CRC Press
Also available as eBook on:
Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinatorial Synthesis of Natural Product-Based Libraries... Read more
Chemistry on the Interface of Natural Products and Combinatorial Chemistry; Armen M. Boldi and Dean R. Dragoli
Natural Products and Combinatorial Chemistry - An Uneasy Past but a Glorious Future; A. Ganesan
Computational Analysis of Natural Molecules and Strategies for the Design of Natural Product-Based Compound Libraries; Florence L. Stahura and Jürgen Bajorath
Accessing Expanded Molecular Diversity through Engineered Biosynthesis of Natural Products; Steven D. Dong and David C. Myles
Natural Product-Based, Chemically and Functionally Diverse Libraries; Peter Eckard, Ulrich Abel, Hans-Falk Rasser, Werner Simon, Bernd Sontag, and
Friedrich G. Hansske
The Use of Polymer-Supported Reagents and Scavengers in the Synthesis of Natural Products; Steven V. Ley, Ian R. Baxendale, and Rebecca M. Myers
Carbohydrate-Derived Small-Molecule Libraries; Armen M. Boldi
In Search of Novel Antibiotics Using a Natural Product Template Approach; Michael J. Sofia
Synthetic Libraries of Fungal Natural Products; Michael C. Pirrung, Zhitao Li, and Hao Liu
Solid-Phase Combinatorial Synthesis Based on Natural Products; Takayuki Doi and Takashi Takahashi
Employing Natural Product-Like Combinatorial Libraries in the Discovery of Lead Libraries; Pedro M. Abreu, Paula S. Branco, and Susan Matthew
Index
Natural Products and Combinatorial Chemistry - An Uneasy Past but a Glorious Future; A. Ganesan
Computational Analysis of Natural Molecules and Strategies for the Design of Natural Product-Based Compound Libraries; Florence L. Stahura and Jürgen Bajorath
Accessing Expanded Molecular Diversity through Engineered Biosynthesis of Natural Products; Steven D. Dong and David C. Myles
Natural Product-Based, Chemically and Functionally Diverse Libraries; Peter Eckard, Ulrich Abel, Hans-Falk Rasser, Werner Simon, Bernd Sontag, and
Friedrich G. Hansske
The Use of Polymer-Supported Reagents and Scavengers in the Synthesis of Natural Products; Steven V. Ley, Ian R. Baxendale, and Rebecca M. Myers
Carbohydrate-Derived Small-Molecule Libraries; Armen M. Boldi
In Search of Novel Antibiotics Using a Natural Product Template Approach; Michael J. Sofia
Synthetic Libraries of Fungal Natural Products; Michael C. Pirrung, Zhitao Li, and Hao Liu
Solid-Phase Combinatorial Synthesis Based on Natural Products; Takayuki Doi and Takashi Takahashi
Employing Natural Product-Like Combinatorial Libraries in the Discovery of Lead Libraries; Pedro M. Abreu, Paula S. Branco, and Susan Matthew
Index
Biography
Boldi\, Armen M.
"[This book] elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the historical developments to the latest technologies, from the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ...A huge amount of references give the readers the opportunity to return to the original papers... ... A large amount of appealing Figures and Schemes illustrate the concepts discussed in the text. The Chapters are well structured... As the authors are from different backgrounds, the book covers various strategies, various synthetic methods, and all types of compound families. ...[A] valuable tool for everybody working in medicinal chemistry as well as the agrochemical, industrial, or academic domains.
- François Diederich, Swiss Federal Institute of Technology, Zurich
"...Elegantly reviews recent efforts to develop high-diversity compound libraries based on natural products. ...From the identification of a suitable target to the building of the library, every step is documented and highlighted by many examples. ..."
- François Diederich, Swiss Federal Institute of Technology, Zurich
"A first-rate source of information to learn about different planning strategies"
-Victor E. Marquez in Journal of Medicinal Chemistry 2007, Vol. 50, No. 5 (2007)
