1st Edition

Comparative Genomics Basic and Applied Research

Edited By James R. Brown Copyright 2008
    408 Pages 8 Color & 64 B/W Illustrations
    by CRC Press

    When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both highly premature and wonderfully inaccurate. In the last ten years, we’ve witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. Moreover, genomic sequences, which are becoming available for several species have proven to be highly relevant to drug research with regard to a number of otherwise intractable conditions.

    Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers in the field. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among its many topics it covers—

    ·         Revolutionary advances in DNA-sequencing technology

    ·         Bold new approaches to the organization and analysis of large phylogenetic data sets

    ·         The impact of comparative genomics on our understanding of evolution

    ·         Efforts toward developing novel antimicrobial drugs, through the use of bacterial pathogen genomes

    Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

    Introduction: The Broad Horizons of Comparative Genomics; James R. Brown
    Basic Research in Comparative GenomicsAdvances in Next-Generation DNA Sequencing Technologies; Michael L. Metzker
    Large-Scale Phylogenetic Reconstruction; Bernard M. E. Moret
    Comparative Genomics of Viruses Using Bioinformatics Tools; Chris Upton and Elliot J. Lefkowitz
    Archaebacteria and the Prokaryote-to-Eukaryote Transition (and the Role of Mitochondria Therein); William Martin, Tal Dagan, and Katrin Henze
    Comparative Genomics of Invertebrates.8; Takeshi Kawashima, Eiichi Shoguchi, Yutaka Satou, and Nori Satoh
    Comparative Vertebrate Genomics; James W. Thomas
    Gaining Insight into Human Population-Specific Selection Pressure; Michael R. Barnes
    Applied Research in Comparative Genomics
    Comparative Genomics in Drug Discovery; James R. Brown
    Comparative Genomics and the Development of Novel Antimicrobials; Diarmaid Hughes
    Comparative Genomics and the Development of Antimalarial and Antiparasitic Therapeutics; Emilio F. Merino, Steven A. Sullivan, and Jane M. Carlton
    Comparative Genomics in AIDS Research; Philippe Lemey, Koen Deforche, and Anne-Mieke Vandamme
    Detailed Comparisons of Cancer Genomes; Timon P. H. Buys, Ian M. Wilson, Bradley P. Coe, Eric H. L. Lee, Jennifer Y. Kennett, William W. Lockwood, Ivy F. L. Tsui, Ashleen Shadeo, Raj Chari, Cathie Garnis, and Wan L. Lam
    Comparative Cancer Epigenomics; Alice N. C. Kuo, Ian M. Wilson, Emily Vucic, Eric H. L. Lee, Jonathan J. Davies, Calum MacAulay, Carolyn J. Brown, and Wan L. Lam
    G Protein-Coupled Receptors and Comparative Genomics; Steven M. Foord
    Comparative Toxicogenomics in Mechanistic and Predictive Toxicology; Josh C. Kwekel, Lyle D. Burgoon, and Tim. R. Zacharewski
    Comparative Genomics and Crop Improvement; Michael Francki and Rudi Appels
    Domestic Animals: A Treasure Trove for Comparative Genomics; Leif Andersson


    James R. Brown